2019
Increased ventromedial prefrontal cortex activity and connectivity predict poor sertraline treatment outcome in late‐life depression
Emam H, Steffens DC, Pearlson G, Wang L. Increased ventromedial prefrontal cortex activity and connectivity predict poor sertraline treatment outcome in late‐life depression. International Journal Of Geriatric Psychiatry 2019, 34: 730-737. PMID: 30761621, PMCID: PMC6480406, DOI: 10.1002/gps.5079.Peer-Reviewed Original ResearchConceptsLate-life depressionSelective serotonin reuptake inhibitorsNonresponder groupFunctional connectivitySSRI responseMADRS scoresResting-state functional magnetic resonance imaging (fMRI) scansMontgomery-Åsberg Depression Rating ScaleMajor depressive disorder patientsPrefrontal cortexMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansSubgenual cingulate areaSerotonin reuptake inhibitorsDepressive disorder patientsAcute treatment responseResonance imaging scansDepression Rating ScaleLower functional connectivityHigher functional connectivityFalse discovery rate correctionResting-state activityDefault mode networkROI connectivityAntidepressant treatment
1996
Schizophrenia: A Disease of Heteromodal Association Cortex?
Pearlson G, Petty R, Ross C, Tien A. Schizophrenia: A Disease of Heteromodal Association Cortex? Neuropsychopharmacology 1996, 14: 1-17. PMID: 8719025, DOI: 10.1016/s0893-133x(96)80054-6.Peer-Reviewed Original ResearchMeSH KeywordsCerebral CortexHumansNeuropsychological TestsPrefrontal CortexSchizophreniaSchizophrenic PsychologyConceptsHeteromodal association cortexAssociation cortexLocal gray matter volumeMultiple brain areasGray matter volumeNeuro-imaging studiesNeuropathologic examinationClinical featuresCortical abnormalitiesPrimary involvementBrain areasMatter volumeCortexDiseaseSchizophreniaConsiderable evidenceMagnetic resonanceFindings formNetwork of circuitsLesionsNeocortexAbnormalities