1996
CT measurement of suprasellar cistern predicts rate of cognitive decline in Alzheimer's disease
Aylward E, Rasmusson D, Brandt J, Raimundo L, Folstein M, Pearlson G. CT measurement of suprasellar cistern predicts rate of cognitive decline in Alzheimer's disease. Journal Of The International Neuropsychological Society 1996, 2: 89-95. PMID: 9375193, DOI: 10.1017/s135561770000093x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAtrophyBrainCisterna MagnaFemaleHumansMaleMiddle AgedNeuropsychological TestsPrognosisSensitivity and SpecificityTomography, X-Ray ComputedConceptsSuprasellar cisternAlzheimer's diseaseAD patientsCT measuresQuantitative computed tomography (CT) measuresMini-Mental State Exam scoreCT measurementsComputed tomography measuresProbable Alzheimer's diseaseState Exam scoreBicaudate ratioBifrontal ratioNeurocognitive declineLateral ventricleThird ventricleCT scanTomography measuresCognitive declineCognitive functionPatientsAdaptive functioningDiseaseScansNeuropsychological measuresCognitive functioning
1991
Effects of Substance Abuse on Ventricular and Sulcal Measures Assessed by Computerised Tomography
Cascella N, Pearlson G, Wong D, Broussolle E, Nagoshi C, Margolin R, London E. Effects of Substance Abuse on Ventricular and Sulcal Measures Assessed by Computerised Tomography. The British Journal Of Psychiatry 1991, 159: 217-221. PMID: 1773237, DOI: 10.1192/bjp.159.2.217.Peer-Reviewed Original ResearchConceptsSubstance abuseSulcal measuresCocaine useSulcal widthWider third ventriclesEffect of ageBrain atrophyBrain ratioChronic useComputerised tomographyThird ventricleNormal controlsAlcohol consumptionBrain morphologyAlcohol usePolydrug abusersSignificant predictorsAgeVentricleSeverityTomographyPositive correlationAbusePossible effectsVentricularCentrum semiovale white matter CT changes associated with normal ageing, Alzheimer's disease and late life depression with and without reversible dementia
Pearlson G, Rabins P, Burns A. Centrum semiovale white matter CT changes associated with normal ageing, Alzheimer's disease and late life depression with and without reversible dementia. Psychological Medicine 1991, 21: 321-328. PMID: 1876637, DOI: 10.1017/s0033291700020420.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseCT attenuation numbersGray matterAttenuation numberCranial CT scanLate-life depressionElderly patientsReversible dementiaPatient groupCT changesLife depressionMajor depressionCentrum semiovaleAttenuation valuesCT scanNormal controlsElderly controlsNeuropsychological evaluationNormal agingDiseasePatientsDepressionCognitive tasksDementiaReliable meansSuprasellar cistern measures as a reflection of dementia in Alzheimer's disease but not Huntington's disease
Aylward E, Karagiozis H, Pearlson G, Folstein M. Suprasellar cistern measures as a reflection of dementia in Alzheimer's disease but not Huntington's disease. Journal Of Psychiatric Research 1991, 25: 31-47. PMID: 1827501, DOI: 10.1016/0022-3956(91)90014-2.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseSuprasellar cisternDisease patientsAD patientsTemporal lobeCognitive statusHuntington's diseaseRespective age-matched controlsBasal forebrain areasAge-matched controlsHuntington's disease patientsForebrain areasEntorhinal cortexCognitive declinePatientsDiseaseBrain widthLobeHDStatusAtrophyDementiaPerceptual ratingsCortex
1989
Structural brain CT changes and cognitive deficits in elderly depressives with and without reversible dementia (‘pseudodementia’)*
Pearlson G, Rabins P, Kim W, Speedie L, Moberg P, Burns A, Bascom M. Structural brain CT changes and cognitive deficits in elderly depressives with and without reversible dementia (‘pseudodementia’)*. Psychological Medicine 1989, 19: 573-584. PMID: 2798631, DOI: 10.1017/s003329170002417x.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationVentricular brain ratioAD patientsDepressed patientsNormal controlsDSM-III major depressionCognitive deficitsShort-term progressionStructural brain abnormalitiesCranial CT scanProbable Alzheimer's diseaseCT attenuation valuesCT valuesReversible dementiaElderly patientsMost patientsBrain ratioCT attenuation numbersCT changesElderly depressivesBrain abnormalitiesDementia syndromesMajor depressionCT scanPatients
1987
Mania After Brain Injury: A Controlled Study of Causative Factors
Starkstein S, Pearlson G, Boston J, Robinson R. Mania After Brain Injury: A Controlled Study of Causative Factors. JAMA Neurology 1987, 44: 1069-1073. PMID: 3632381, DOI: 10.1001/archneur.1987.00520220065019.Peer-Reviewed Original ResearchConceptsBrain injuryVentricle/brain ratiosPossible family historyFocal brain injurySecondary maniaRight hemisphere lesionsSubcortical atrophyBrain ratioDepressive episodeLimbic areasManic patientsFamily historyManic syndromeFocal lesionsAffective disordersPatientsInjuryLesionsCausative factorsRare occurrenceHemisphere lesionsGenetic loadingRight hemisphereManiaRight hemisphere involvementIncreased ventricle-to-brain ratio in late-onset schizophrenia
Rabins P, Pearlson G, Jayaram G, Steele C, Tune L. Increased ventricle-to-brain ratio in late-onset schizophrenia. American Journal Of Psychiatry 1987, 144: 1216-1218. PMID: 3631322, DOI: 10.1176/ajp.144.9.1216.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAlzheimer DiseaseBrainCerebral VentriclesDelusionsFemaleHallucinationsHumansMaleMiddle AgedSchizophreniaTomography, X-Ray Computed
1986
Cerebral ventricular size and cerebrospinal fluid acetylcholinesterase levels in senile dementia of the Alzheimer type
Pearlson G, Tune L. Cerebral ventricular size and cerebrospinal fluid acetylcholinesterase levels in senile dementia of the Alzheimer type. Psychiatry Research 1986, 17: 23-29. PMID: 3484831, DOI: 10.1016/0165-1781(86)90038-7.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholinesteraseAgedAlzheimer DiseaseBrainCerebral VentriculographyFemaleHumansMaleTomography, X-Ray ComputedConceptsVentricle-brain ratioMini-Mental State ExaminationSenile dementiaComputed tomographyAlzheimer typeCerebrospinal fluid acetylcholinesterase activityLateral ventricle-brain ratiosCerebral ventricular sizeDuration of illnessAChE activityCSF AChE activityDegree of dementiaCerebral atrophyVentricular sizeCT scanDilutional effectState ExaminationCognitive impairmentAcetylcholinesterase levelsRadioenzymatic assayDementiaAcetylcholinesterase activityLaboratory dataPatientsSignificant correlation
1985
Symptomatic, Familial, Perinatal, and Social Correlates of Computerized Axial Tomography (CAT) Changes in Schizophrenics and Bipolars
PEARLSON G, GARBACZ D, MOBERG P, AHN H, DEPAULO J. Symptomatic, Familial, Perinatal, and Social Correlates of Computerized Axial Tomography (CAT) Changes in Schizophrenics and Bipolars. The Journal Of Nervous And Mental Disease 1985, 173: 42-50. PMID: 3965611, DOI: 10.1097/00005053-198501000-00007.Peer-Reviewed Original ResearchConceptsVentricular enlargementFamily historyNegative symptomsComputerized axial tomography scanLateral ventricular enlargementAxial tomography scanPast psychiatric historyEarly brain damageMarked ventricular enlargementSubgroup of schizophrenicsPoor premorbid adjustmentLateral ventricularTomography changesBrain ratioPatient groupBrain damageTomography scanPsychiatric illnessPsychiatric historyBipolar patientsNormal controlsEarly onsetPatientsPremorbid adjustmentSignificant proportion
1984
Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder
Pearlson G, Garbacz D, Breakey W, Ahn H, DePaulo J. Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder. Psychiatry Research 1984, 12: 1-9. PMID: 6589656, DOI: 10.1016/0165-1781(84)90133-1.Peer-Reviewed Original ResearchNORTRIPTYLINE TREATMENT OF POST-STROKE DEPRESSION: A DOUBLE-BLIND STUDY
Lipsey J, Pearlson G, Robinson R, Rao K, Price T. NORTRIPTYLINE TREATMENT OF POST-STROKE DEPRESSION: A DOUBLE-BLIND STUDY. The Lancet 1984, 323: 297-300. PMID: 6141377, DOI: 10.1016/s0140-6736(84)90356-8.Peer-Reviewed Original ResearchConceptsPost-stroke depressionDouble-blind studyDepression ScaleEfficacy of nortriptylinePlacebo-treated patientsSerum nortriptyline levelsHamilton Depression ScalePresent State ExaminationZung Depression ScaleStroke patientsTherapeutic rangeMajor depressionNortriptyline levelsDemonstrated efficacyState ExaminationPatientsNortriptylineDepressionGreater improvementTreatmentSimilar groupsEfficacyImportant addition
1983
Mood Change following Bilateral Hemisphere Brain Injury
Lipsey J, Robinson R, Pearlson G, Rao K, Price T. Mood Change following Bilateral Hemisphere Brain Injury. The British Journal Of Psychiatry 1983, 143: 266-273. PMID: 6626839, DOI: 10.1192/bjp.143.3.266.Peer-Reviewed Original ResearchConceptsHemisphere brain injuryFunctional physical impairmentBrain injuryCognitive impairmentPhysical impairmentLeft frontal lobe lesionFrontal lobe lesionsThromboembolic strokeBrain lesionsSuch injuriesCT scanLesion locationDepression severityLobe lesionsLesion proximityDepressive symptomatologyLesion ageFrontal poleInjuryMood changesPatientsImpairmentMood ScaleLesionsDepression
1982
Use of CT scanning in psychiatry
Pearlson G, Veroff A, Wise T. Use of CT scanning in psychiatry. Journal Of The Academy Of Consultation-Liaison Psychiatry 1982, 23: 993-1004. PMID: 7178411, DOI: 10.1016/s0033-3182(82)73291-8.Peer-Reviewed Original ResearchMeSH KeywordsBrain Damage, ChronicDiagnosis, DifferentialHumansNeurocognitive DisordersTomography, X-Ray ComputedCT scan and neuropsychological correlates of Alzheimer's Disease and Huntington's Disease
Veroff A, Pearlson G, Ahn H. CT scan and neuropsychological correlates of Alzheimer's Disease and Huntington's Disease. Brain And Cognition 1982, 1: 177-184. PMID: 6242676, DOI: 10.1016/0278-2626(82)90015-x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseBrainFemaleFrontal LobeHumansHuntington DiseaseMaleMiddle AgedTemporal LobeTomography, X-Ray ComputedVerbal BehaviorConceptsDisease patientsAlzheimer's diseaseAlzheimer's disease patientsCT scan interpretationHuntington's disease patientsCT scan informationCT attenuation valuesClinical characteristicsPrimary neuropathologyDementia syndromesCT scanScan interpretationNormal agingDiseaseHuntington's diseaseAphasia subtypesNeuropsychological correlatesPatientsSignificant correlationDouble dissociationAttenuation valuesRecent studiesScan informationLobe densityNeuropathology
1981
COMPUTERISED TOMOGRAPHIC SCAN CHANGES IN MANIC-DEPRESSIVE ILLNESS
Pearlson G, Veroff A. COMPUTERISED TOMOGRAPHIC SCAN CHANGES IN MANIC-DEPRESSIVE ILLNESS. The Lancet 1981, 318: 470. PMID: 6115222, DOI: 10.1016/s0140-6736(81)90798-4.Peer-Reviewed Original ResearchAdolescentAdultBipolar DisorderBrainCerebral VentriculographyFemaleHumansMaleMiddle AgedTomography, X-Ray Computed