2023
Characterization of the extracellular free water signal in schizophrenia using multi-site diffusion MRI harmonization
Cetin-Karayumak S, Lyall A, Di Biase M, Seitz-Holland J, Zhang F, Kelly S, Elad D, Pearlson G, Tamminga C, Sweeney J, Clementz B, Schretlen D, Stegmayer K, Walther S, Lee J, Crow T, James A, Voineskos A, Buchanan R, Szeszko P, Malhotra A, Keshavan M, Shenton M, Rathi Y, Pasternak O, Kubicki M. Characterization of the extracellular free water signal in schizophrenia using multi-site diffusion MRI harmonization. Molecular Psychiatry 2023, 28: 2030-2038. PMID: 37095352, PMCID: PMC11146151, DOI: 10.1038/s41380-023-02068-1.Peer-Reviewed Original ResearchDuration of illnessIllness stageHealthy controlsWhole brain white matterDifferent illness stagesFree-water imagingSchizophrenia spectrum disordersYounger patientsBrain white matterExtracellular free waterProlonged illnessEarly psychosisDiffusion magnetic resonanceWhite matterDemographic dataIllnessSchizophreniaSmall effect sizesShort durationTime courseAgeEffect sizeSignificant global increaseInternational sitesDisorders
2018
T22. PITUITARY GLAND VOLUME DIFFERENCES IN INDIVIDUALS WITH PSYCHOSIS: RESULTS FROM THE BIPOLAR-SCHIZOPHRENIA NETWORK ON INTERMEDIATE PHENOTYPES (B-SNIP) STUDY
Guimond S, Tingue S, Devenyi G, Tang Y, Mike L, Chakravarty M, Sweeney J, Pearlson G, Clementz B, Tamminga C, Keshavan M. T22. PITUITARY GLAND VOLUME DIFFERENCES IN INDIVIDUALS WITH PSYCHOSIS: RESULTS FROM THE BIPOLAR-SCHIZOPHRENIA NETWORK ON INTERMEDIATE PHENOTYPES (B-SNIP) STUDY. Schizophrenia Bulletin 2018, 44: s121-s121. PMCID: PMC5888564, DOI: 10.1093/schbul/sby016.298.Peer-Reviewed Original ResearchPituitary gland volumeLarger pituitary glandsDuration of illnessHealthy controlsGland volumePituitary glandPsychotic bipolar disorderSymptom severityBipolar-Schizophrenia NetworkPituitary volumeSchizoaffective disorderLarger pituitary gland volumesClinical diagnosisLarger pituitary volumeSubgroup of patientsSignificant main effectGreater symptom severitySignificant subgroup differencesIndependent t-testAdrenal axisPatient groupIntermediate Phenotypes (B-SNIP) consortiumMAGeT Brain algorithmStructural magnetic resonance imagesIntermediate Phenotypes (B-SNIP) study
1993
Dopamine D2 receptor density estimates in schizophrenia: A positron emission tomography study with11C-N-methylspiperone
Tune L, Wong D, Pearlson G, Strauss M, Young T, Shaya E, Dannals R, Wilson A, Ravert H, Sapp J, Cooper T, Chase G, Wagner H. Dopamine D2 receptor density estimates in schizophrenia: A positron emission tomography study with11C-N-methylspiperone. Psychiatry Research 1993, 49: 219-237. PMID: 7909948, DOI: 10.1016/0165-1781(93)90063-m.Peer-Reviewed Original ResearchConceptsPositron emission tomographySchizophrenic patientsBmax valuesEntire groupControl subjectsEmission tomographyDopamine D2 receptor densityNeuroleptic-free patientsDuration of illnessChronic schizophrenic patientsD2 receptor densityClinical characteristicsPatient populationReceptor abnormalitiesCorpus striatumClinical dataReceptor densityPatientsControl groupFunction of ageLate manifestationDifferent radioligandsFour-compartment modelSignificant differencesRadioligandD2 receptor estimates in chronic schizophrenia reveal significant effects of age, sex, duration of illness
Tune L, Wong D, Pearlson G. D2 receptor estimates in chronic schizophrenia reveal significant effects of age, sex, duration of illness. Schizophrenia Research 1993, 9: 211-212. DOI: 10.1016/0920-9964(93)90456-s.Peer-Reviewed Original Research
1986
Cerebral ventricular size and cerebrospinal fluid acetylcholinesterase levels in senile dementia of the Alzheimer type
Pearlson G, Tune L. Cerebral ventricular size and cerebrospinal fluid acetylcholinesterase levels in senile dementia of the Alzheimer type. Psychiatry Research 1986, 17: 23-29. PMID: 3484831, DOI: 10.1016/0165-1781(86)90038-7.Peer-Reviewed Original ResearchConceptsVentricle-brain ratioMini-Mental State ExaminationSenile dementiaComputed tomographyAlzheimer typeCerebrospinal fluid acetylcholinesterase activityLateral ventricle-brain ratiosCerebral ventricular sizeDuration of illnessAChE activityCSF AChE activityDegree of dementiaCerebral atrophyVentricular sizeCT scanDilutional effectState ExaminationCognitive impairmentAcetylcholinesterase levelsRadioenzymatic assayDementiaAcetylcholinesterase activityLaboratory dataPatientsSignificant correlation