2013
Resting State Electroencephalogram Oscillatory Abnormalities in Schizophrenia and Psychotic Bipolar Patients and Their Relatives from the Bipolar and Schizophrenia Network on Intermediate Phenotypes Study
Narayanan B, O’Neil K, Berwise C, Stevens MC, Calhoun VD, Clementz BA, Tamminga CA, Sweeney JA, Keshavan MS, Pearlson GD. Resting State Electroencephalogram Oscillatory Abnormalities in Schizophrenia and Psychotic Bipolar Patients and Their Relatives from the Bipolar and Schizophrenia Network on Intermediate Phenotypes Study. Biological Psychiatry 2013, 76: 456-465. PMID: 24439302, PMCID: PMC5045030, DOI: 10.1016/j.biopsych.2013.12.008.Peer-Reviewed Original ResearchConceptsFirst-degree relativesSlow beta activityFast alpha activitySZ probandsAlpha activityHealthy control subjectsBeta activityRelative risk estimatesFrontal delta activityEEG spectral activityModerate relative riskPsychotic bipolar patientsLow-frequency activityPsychotic bipolar probandsGroup independent component analysisControl subjectsRelative riskPost-hoc pair-wise comparisonsBipolar patientsGenetic predispositionIntermediate Phenotypes (B-SNIP) studyOscillatory abnormalitiesAnalysis of covarianceUnique endophenotypesBipolar disorder
1997
Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder
Pearlson G, Barta P, Powers R, Menon R, Richards S, Aylward E, Federman E, Chase G, Petty R, Tien A. Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biological Psychiatry 1997, 41: 1-14. PMID: 8988790, DOI: 10.1016/s0006-3223(96)00373-3.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusAnterior superior temporal gyrusBipolar disorderSchizophrenic patientsSuperior temporal gyral volumeMagnetic resonance imaging studyTemporal lobe changesMedial temporal structuresRight anterior superior temporal gyrusResonance imaging studyGlobal brain measuresPosterior superior temporal gyrusGyral volumeHealthy controlsMRI measuresTemporal lobeBipolar patientsBipolar subjectsNormal controlsImaging studiesTemporal gyrusPatientsSchizophreniaBilateral volumesBrain measures
1985
Symptomatic, Familial, Perinatal, and Social Correlates of Computerized Axial Tomography (CAT) Changes in Schizophrenics and Bipolars
PEARLSON G, GARBACZ D, MOBERG P, AHN H, DEPAULO J. Symptomatic, Familial, Perinatal, and Social Correlates of Computerized Axial Tomography (CAT) Changes in Schizophrenics and Bipolars. The Journal Of Nervous And Mental Disease 1985, 173: 42-50. PMID: 3965611, DOI: 10.1097/00005053-198501000-00007.Peer-Reviewed Original ResearchConceptsVentricular enlargementFamily historyNegative symptomsComputerized axial tomography scanLateral ventricular enlargementAxial tomography scanPast psychiatric historyEarly brain damageMarked ventricular enlargementSubgroup of schizophrenicsPoor premorbid adjustmentLateral ventricularTomography changesBrain ratioPatient groupBrain damageTomography scanPsychiatric illnessPsychiatric historyBipolar patientsNormal controlsEarly onsetPatientsPremorbid adjustmentSignificant proportion
1984
Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder
Pearlson G, Garbacz D, Breakey W, Ahn H, DePaulo J. Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder. Psychiatry Research 1984, 12: 1-9. PMID: 6589656, DOI: 10.1016/0165-1781(84)90133-1.Peer-Reviewed Original Research