2016
Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury
Wu B, Mottola G, Chatterjee A, Lance KD, Chen M, Siguenza IO, Desai TA, Conte MS. Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury. Journal Of Vascular Surgery 2016, 65: 207-217.e3. PMID: 27034112, PMCID: PMC5040608, DOI: 10.1016/j.jvs.2016.01.030.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAnimalsAortaCardiovascular AgentsCarotid Artery DiseasesCell MovementCell ProliferationCells, CulturedCytoskeletonDisease Models, AnimalDocosahexaenoic AcidsDrug CarriersDrug CompoundingHyperplasiaInflammation MediatorsKi-67 AntigenLactic AcidMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaOxidative StressPoloxamerPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRats, Sprague-DawleyTime FactorsTranscription Factor RelAConceptsLocal perivascular deliveryPerivascular deliveryRat modelCarotid angioplastyNeointimal hyperplasiaResolvin D1Inflammatory pathwaysNeointimal formationArterial smooth muscle cell proliferationNuclear factor-κB activationEffects of RvD1Smooth muscle cell proliferationKi67 proliferation indexResolution of inflammationNegative vessel remodelingMuscle cell proliferationSmooth muscle cellsMuscle cell responseWrap groupArterial injuryRat aortaEvidence of cytotoxicityRvD1Lipid mediatorsProliferation index
2014
The Pro-Resolving Lipid Mediator Maresin 1 (MaR1) Attenuates Inflammatory Signaling Pathways in Vascular Smooth Muscle and Endothelial Cells
Chatterjee A, Sharma A, Chen M, Toy R, Mottola G, Conte MS. The Pro-Resolving Lipid Mediator Maresin 1 (MaR1) Attenuates Inflammatory Signaling Pathways in Vascular Smooth Muscle and Endothelial Cells. PLOS ONE 2014, 9: e113480. PMID: 25409514, PMCID: PMC4237455, DOI: 10.1371/journal.pone.0113480.Peer-Reviewed Original ResearchMeSH KeywordsCell AdhesionCells, CulturedCyclic AMPDocosahexaenoic AcidsDown-RegulationEndothelial CellsE-SelectinHumansMuscle, Smooth, VascularNADPH OxidasesNF-kappa BOxidative StressPhosphorylationReactive Oxygen SpeciesSignal TransductionTranscription Factor RelATumor Necrosis Factor-alphaU937 CellsUp-RegulationConceptsInflammatory signaling pathwaysBroad anti-inflammatory actionsMonocyte adhesionCyclic AMPTumor necrosis factor alphaAdhesion molecules E-selectinPro-resolving responseNF-κB p65 subunitPro-inflammatory mediatorsAnti-inflammatory actionPro-inflammatory signalsVascular smooth muscleNecrosis factor alphaAttenuation of TNFHuman saphenous vein ECsHuman vascular endothelialBioactive lipid mediatorsNF-κB activationSmooth muscle cellsTNF-α effectSignaling pathwaysBronchial epithelial cellsIntracellular cyclic AMPTime-dependent increaseVascular inflammation