2022
17R/S-Benzo-RvD1, a synthetic resolvin D1 analogue, attenuates neointimal hyperplasia in a rat model of acute vascular injury
Kim AS, Werlin EC, Kagaya H, Chen M, Wu B, Mottola G, Jan M, Conte MS. 17R/S-Benzo-RvD1, a synthetic resolvin D1 analogue, attenuates neointimal hyperplasia in a rat model of acute vascular injury. PLOS ONE 2022, 17: e0264217. PMID: 35226675, PMCID: PMC8884511, DOI: 10.1371/journal.pone.0264217.Peer-Reviewed Original ResearchConceptsSpecialized lipid mediatorsNeointimal hyperplasiaVascular injuryRAW 264.7 cellsEndothelial cellsCarotid angioplastyPhagocytic activityAcute arterial injuryPro-resolving activitiesAcute vascular injuryCytokine-stimulated endothelial cellsP65 nuclear translocationAnti-migratory activityMurine RAW 264.7 cellsArterial injuryPersistent inflammationResolvin D1Ki67 expressionNeointimal areaSimilar efficacyLeukocyte recruitmentRat modelKi-67Lipid mediatorsNuclear translocation assays
2019
Oral Resolvin D1 attenuates early inflammation but not intimal hyperplasia in a rat carotid angioplasty model
Mottola G, Werlin EC, Wu B, Chen M, Chatterjee A, Schaller MS, Conte MS. Oral Resolvin D1 attenuates early inflammation but not intimal hyperplasia in a rat carotid angioplasty model. Prostaglandins And Other Lipid Mediators 2019, 146: 106401. PMID: 31841663, PMCID: PMC7265259, DOI: 10.1016/j.prostaglandins.2019.106401.Peer-Reviewed Original ResearchConceptsIntimal hyperplasiaResolvin D1Post-operative day 3Phagocytosis activityRat carotid angioplasty modelCAMP levelsLocal inflammatory responsePro-inflammatory genesArterial inflammationCarotid angioplastyOral gavageAcute inflammationVascular injuryThoracic aortaAngioplasty modelEarly inflammationInflammatory responseOral administrationPlasma concentrationsCarotid arteryRvD1Lipid mediatorsAnimal modelsDay 3Inflammation
2016
Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury
Wu B, Mottola G, Chatterjee A, Lance KD, Chen M, Siguenza IO, Desai TA, Conte MS. Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury. Journal Of Vascular Surgery 2016, 65: 207-217.e3. PMID: 27034112, PMCID: PMC5040608, DOI: 10.1016/j.jvs.2016.01.030.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAnimalsAortaCardiovascular AgentsCarotid Artery DiseasesCell MovementCell ProliferationCells, CulturedCytoskeletonDisease Models, AnimalDocosahexaenoic AcidsDrug CarriersDrug CompoundingHyperplasiaInflammation MediatorsKi-67 AntigenLactic AcidMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaOxidative StressPoloxamerPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRats, Sprague-DawleyTime FactorsTranscription Factor RelAConceptsLocal perivascular deliveryPerivascular deliveryRat modelCarotid angioplastyNeointimal hyperplasiaResolvin D1Inflammatory pathwaysNeointimal formationArterial smooth muscle cell proliferationNuclear factor-κB activationEffects of RvD1Smooth muscle cell proliferationKi67 proliferation indexResolution of inflammationNegative vessel remodelingMuscle cell proliferationSmooth muscle cellsMuscle cell responseWrap groupArterial injuryRat aortaEvidence of cytotoxicityRvD1Lipid mediatorsProliferation index