2002
On the natriuretic effect of verapamil: inhibition of ENaC and transepithelial sodium transport
Segal AS, Hayslett JP, Desir GV. On the natriuretic effect of verapamil: inhibition of ENaC and transepithelial sodium transport. American Journal Of Physiology. Renal Physiology 2002, 283: f765-f770. PMID: 12217868, DOI: 10.1152/ajprenal.00253.2001.Peer-Reviewed Original ResearchMeSH KeywordsAldosteroneAnimalsBiological Transport, ActiveCalcium Channel BlockersCells, CulturedDose-Response Relationship, DrugElectrophysiologyEpithelial Sodium ChannelsEpitheliumIn Vitro TechniquesInsulinKidneyKidney Tubules, CollectingNatriuresisNifedipineOocytesPatch-Clamp TechniquesSodiumSodium Channel BlockersSodium ChannelsVasopressinsVerapamilXenopus laevisConceptsNatriuretic effectDirect tubular effectAdministration of verapamilRemoval of extracellularTubular effectsTransepithelial sodium transportHemodynamic changesInhibition of ENaCSurrogate markerChannel blockersMicroM verapamilDistal tubulesA6 cellsMicroM amilorideUssing chambersVerapamilL-typeSodium transportBasolateral sideTransepithelial resistanceSignificant increaseApical sidePermeable supportsInhibitionTransepithelial
2001
The distal convoluted tubule of rabbit kidney does not express a functional sodium channel
Velázquez H, Silva T, Andújar E, Desir G, Ellison D, Greger R. The distal convoluted tubule of rabbit kidney does not express a functional sodium channel. American Journal Of Physiology. Renal Physiology 2001, 280: f530-f539. PMID: 11181416, DOI: 10.1152/ajprenal.2001.280.3.f530.Peer-Reviewed Original ResearchAnimalsBlotting, NorthernCalcium-Binding ProteinsCloning, MolecularEndosomal Sorting Complexes Required for TransportEpithelial Sodium ChannelsIn Vitro TechniquesKidneyKidney Tubules, DistalLigasesMolecular Sequence DataNedd4 Ubiquitin Protein LigasesNephronsPerfusionRabbitsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSodium ChannelsTissue DistributionUbiquitin-Protein Ligases
2000
KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels
Lang R, Lee G, Liu W, Tian S, Rafi H, Orias M, Segal A, Desir G. KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. American Journal Of Physiology. Renal Physiology 2000, 278: f1013-f1021. PMID: 10836990, DOI: 10.1152/ajprenal.2000.278.6.f1013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCyclic Nucleotide-Gated Cation ChannelsDNA PrimersFemaleHumansIn Vitro TechniquesIon Channel GatingIon ChannelsMembrane PotentialsOocytesPatch-Clamp TechniquesPotassium Channel BlockersPotassium ChannelsPotassium Channels, Voltage-GatedRabbitsRecombinant ProteinsSecond Messenger SystemsShaker Superfamily of Potassium ChannelsXenopus laevis