2021
Challenges in interpreting cytokine data in COVID-19 affect patient care and management
Wang SY, Takahashi T, Pine AB, Damsky WE, Simonov M, Zhang Y, Kieras E, Price CC, King BA, Siegel MD, Desir GV, Lee AI, Iwasaki A, Chun HJ. Challenges in interpreting cytokine data in COVID-19 affect patient care and management. PLOS Biology 2021, 19: e3001373. PMID: 34358229, PMCID: PMC8372945, DOI: 10.1371/journal.pbio.3001373.Peer-Reviewed Original Research
2017
Extracellular renalase protects cells and organs by outside‐in signalling
Wang Y, Safirstein R, Velazquez H, Guo X, Hollander L, Chang J, Chen T, Mu J, Desir GV. Extracellular renalase protects cells and organs by outside‐in signalling. Journal Of Cellular And Molecular Medicine 2017, 21: 1260-1265. PMID: 28238213, PMCID: PMC5487909, DOI: 10.1111/jcmm.13062.Peer-Reviewed Original ResearchConceptsProtective effectNovel therapeutic strategiesCancer cell growthBlood pressureOrgan injuryJAK/STATHeart rateTherapeutic strategiesToxic injuryCytoprotective actionMitogen-activated protein kinase pathwayRenalaseTranslational opportunitiesTumor cellsCellular actionsProtein kinase BInitial reportProtein kinase pathwayInjuryKinase BOrgansKinase pathwayGrowth-related genesCell growthExtracellular renalase
2014
Renalase
Guo X, Wang L, Velazquez H, Safirstein R, Desir GV. Renalase. Current Opinion In Nephrology & Hypertension 2014, 23: 513-518. PMID: 24992568, PMCID: PMC4383282, DOI: 10.1097/mnh.0000000000000044.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsEnzymatic functionType 1 diabetesMitogen-activated protein kinase pathwayNucleotide polymorphismsProtein kinase BProtein kinase pathwayCellular actionsPlasma membraneKinase pathwayKinase BPotential therapeutic utilityCertain single nucleotide polymorphismsEnzymatic propertiesIschemic strokeImmune modulatorsRenalase geneTherapeutic utilityCytoprotective effectsClinical implicationsRenalaseConsistent associationPotential roleDiabetesCytokines