2023
Receipt of opioid use disorder treatments prior to fatal overdoses and comparison to no treatment in Connecticut, 2016–17
Heimer R, Black A, Lin H, Grau L, Fiellin D, Howell B, Hawk K, D'Onofrio G, Becker W. Receipt of opioid use disorder treatments prior to fatal overdoses and comparison to no treatment in Connecticut, 2016–17. Drug And Alcohol Dependence 2023, 254: 111040. PMID: 38043226, PMCID: PMC10872282, DOI: 10.1016/j.drugalcdep.2023.111040.Peer-Reviewed Original ResearchConceptsNon-medication treatmentsRelative riskOpioid overdose deathsIncidence rateMOUD treatmentOverdose deathsOpioid use disorder treatmentResults Incidence ratesRetrospective cohort studyDifferent treatment modalitiesPopulation-level effortsUse disorder treatmentFatal opioid poisoningsCohort studyOpioid poisoningTreatment modalitiesConclusion ExposurePoisoning deathsFatal overdosesTreatment exposureDisorder treatmentDeathTreatmentMethadoneRisk
2021
Analysis of Health Trajectories Leading to Adverse Opioid-Related Events.
Gilson AS, Chartash D, Chang D, Hawk K, D'Onofrio G, Haimovich AD, Fiellin DA, Taylor RA. Analysis of Health Trajectories Leading to Adverse Opioid-Related Events. AMIA Joint Summits On Translational Science Proceedings 2021, 2021: 248-256. PMID: 34457139, PMCID: PMC8378649.Peer-Reviewed Original ResearchConceptsRelative riskHealth trajectoriesHealth service eventsPatient risk factorsMental health diagnosesHigher relative riskLargest relative riskCombination of diagnosisViral hepatitisPatient cohortRisk factorsRisk-based interventionsMental health codesNatural historyPatient diagnosisHealth diagnosisDiagnosisTherapy agentsPotential causal mechanismsRiskAverage populationAOEHealth CodeHepatitisOpioids
1994
The lack of efficacy of phenytoin in the prevention of recurrent alcohol-related seizures
Rathlev N, D'Onofrio G, Fish S, Harrison P, Bernstein E, Hossack R, Pickens L. The lack of efficacy of phenytoin in the prevention of recurrent alcohol-related seizures. Annals Of Emergency Medicine 1994, 23: 513-518. PMID: 8135426, DOI: 10.1016/s0196-0644(94)70070-2.Peer-Reviewed Original ResearchConceptsAlcohol-related seizuresSix-hour observation periodNormal saline placeboDouble-blind trialObservation periodConfidence intervalsLack of efficacyChronic alcohol abuseYears of ageChi 2 analysisPlacebo groupConsecutive adultsEligible subjectsPhenytoin groupSaline placeboGeneralized seizuresPhenytoin administrationSecond seizureEmergency departmentNormal salineRelative riskTeaching hospitalAlcohol abuseDrug AdministrationSeizures