2022
Sex Differences in Clopidogrel Effects Among Young Patients With Acute Coronary Syndrome: A Role for Genetics?
Kaur A, Dreyer R, Marsh T, Thanassoulis G, Raparelli V, D’Onofrio G, Engert J, Pilote L. Sex Differences in Clopidogrel Effects Among Young Patients With Acute Coronary Syndrome: A Role for Genetics? CJC Open 2022, 4: 970-978. PMID: 36444366, PMCID: PMC9700217, DOI: 10.1016/j.cjco.2022.07.013.Peer-Reviewed Original ResearchAcute coronary syndromeUsers of clopidogrelCoronary syndromeClinical outcomesMultivariable logistic regression modelSex differencesAdverse clinical outcomesWorse clinical outcomesTime of presentationGenetic risk scoreLogistic regression modelsSex-specific impactClopidogrel usersAtherothrombotic eventsCardiac eventsYounger patientsClopidogrel effectAntiplatelet agentsClopidogrelHigh riskRisk scoreIndependent factorsRole of sexHealth outcomesReadmission
2018
Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study
Safdar B, Spatz ES, Dreyer RP, Beltrame JF, Lichtman JH, Spertus JA, Reynolds HR, Geda M, Bueno H, Dziura JD, Krumholz HM, D'Onofrio G. Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study. Journal Of The American Heart Association 2018, 7: e009174. PMID: 29954744, PMCID: PMC6064896, DOI: 10.1161/jaha.118.009174.Peer-Reviewed Original ResearchConceptsMI-CAD patientsNonobstructive coronary arteriesMI-CADYounger patientsClinical profileCoronary arteryMyocardial infarctionTraditional cardiac risk factorsAcute myocardial infarction patientsCardiac risk factorsGestational diabetes mellitusMyocardial infarction patientsTimes higher oddsMINOCA patientsSAQ qualityVIRGO StudyClinical characteristicsHypercoaguable stateDiabetes mellitusObstructive diseaseClinical outcomesInfarction patientsRisk factorsMINOCAPsychosocial status