Featured Publications
The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study
Moledina DG, Simonov M, Yamamoto Y, Alausa J, Arora T, Biswas A, Cantley LG, Ghazi L, Greenberg JH, Hinchcliff M, Huang C, Mansour SG, Martin M, Peixoto A, Schulz W, Subair L, Testani JM, Ugwuowo U, Young P, Wilson FP. The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study. American Journal Of Kidney Diseases 2021, 77: 490-499.e1. PMID: 33422598, PMCID: PMC7791318, DOI: 10.1053/j.ajkd.2020.12.007.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedCohort StudiesCOVID-19C-Reactive ProteinCreatinineDiureticsFemaleHospital MortalityHumansIntensive Care UnitsLength of StayMaleMiddle AgedProportional Hazards ModelsRenal DialysisRenal Insufficiency, ChronicRespiration, ArtificialRisk FactorsSARS-CoV-2Severity of Illness IndexUnited StatesVasoconstrictor AgentsConceptsAcute kidney injurySARS-CoV-2Cohort studyRisk factorsCOVID-19Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testingTime-updated Cox proportional hazards modelsDialysis-requiring acute kidney injuryYale New Haven Health SystemHigher inflammatory marker levelsMore acute kidney injuryCox proportional hazards modelMulticenter cohort studyHigh rateInflammatory marker levelsTraditional risk factorsProportional hazards modelCoronavirus disease 2019KDIGO criteriaNephrotoxin exposureKidney injuryInjury independentUnivariable analysisNasopharyngeal samplesMarker levels
2022
Nocturnal Dipping and Kidney Function Decline: Findings From the CKD in Children Study
Bakhoum C, Phadke M, Deng Y, Samuels J, Garimella P, Furth S, Wilson F, Ix J. Nocturnal Dipping and Kidney Function Decline: Findings From the CKD in Children Study. Kidney International Reports 2022, 7: 2446-2453. PMID: 36531891, PMCID: PMC9751682, DOI: 10.1016/j.ekir.2022.08.002.Peer-Reviewed Original ResearchChronic kidney diseaseGlomerular filtration rateIohexol glomerular filtration rateNocturnal dippingDipping statusKidney diseaseKidney failureEnd-stage kidney diseaseCox proportional hazards modelKidney failure eventsKidney function declineBlood pressure declineProportional hazards modelMore rapid declineCKiD cohortGFR declineCreatinine ratioKidney functionFunction declineMean ageUrine proteinFiltration rateGlomerular diseaseNondippingChild CohortMortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy
Baker ML, Yamamoto Y, Perazella MA, Dizman N, Shirali AC, Hafez N, Weinstein J, Simonov M, Testani JM, Kluger HM, Cantley LG, Parikh CR, Wilson FP, Moledina DG. Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy. Journal For ImmunoTherapy Of Cancer 2022, 10: e004421. PMID: 35354588, PMCID: PMC8968986, DOI: 10.1136/jitc-2021-004421.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisAcute kidney injuryImmune checkpoint inhibitor therapyCheckpoint inhibitor therapyICI therapyKidney injuryInhibitor therapyInterstitial nephritisTime-varying Cox proportional hazards modelsHigher peak serum creatinineSevere acute kidney injuryCancer typesCox proportional hazards modelAssociations of biopsyBaseline laboratory valuesObservational cohort studyPeak serum creatinineFavorable treatment responseProportional hazards modelAKI patientsTherapy initiationCohort studySerum creatinineUnivariable analysisImmune activationSevere inpatient hypertension prevalence and blood pressure response to antihypertensive treatment
Ghazi L, Li F, Chen X, Simonov M, Yamamoto Y, Biswas A, Hanna J, Shah T, Townsend R, Peixoto A, Wilson FP. Severe inpatient hypertension prevalence and blood pressure response to antihypertensive treatment. Journal Of Clinical Hypertension 2022, 24: 339-349. PMID: 35174627, PMCID: PMC8925013, DOI: 10.1111/jch.14431.Peer-Reviewed Original ResearchConceptsSevere hypertensionBlood pressure responseBP elevationUntreated patientsCox proportional hazards modelRetrospective cohort studyPressure responseProportional hazards modelAntihypertensive treatmentInpatient hypertensionMore comorbiditiesPossible overtreatmentHospitalized adultsCohort studyHypertension prevalenceArterial pressureHospitalized patientsTreatment guidelinesHypertensionGreater rateHazards modelPatientsAntihypertensivesTreatmentAdmission
2020
Novel Risk Factors for Progression of Diabetic and Nondiabetic CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
Anderson AH, Xie D, Wang X, Baudier RL, Orlandi P, Appel LJ, Dember LM, He J, Kusek JW, Lash JP, Navaneethan SD, Ojo A, Rahman M, Roy J, Scialla JJ, Sondheimer JH, Steigerwalt SP, Wilson FP, Wolf M, Feldman HI, Investigators C, Go A, Townsend R. Novel Risk Factors for Progression of Diabetic and Nondiabetic CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. American Journal Of Kidney Diseases 2020, 77: 56-73.e1. PMID: 32866540, PMCID: PMC7752839, DOI: 10.1053/j.ajkd.2020.07.011.Peer-Reviewed Original ResearchConceptsChronic Renal Insufficiency Cohort (CRIC) StudyIndependent risk factorCKD progressionNovel risk factorsRisk factorsCohort studyComposite outcomeN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideChronic kidney disease progressionGlomerular filtration rate (eGFR) slopeHigh-sensitivity troponin TCox proportional hazards modelStudy designProgression of diabeticsUrinary neutrophil gelatinaseUrinary NGAL levelsUS clinical centersKidney disease progressionLow serum bicarbonateProspective cohort studyKidney replacement therapyHigh-risk subgroupsProportional hazards modelNumerous risk factors
2019
Insulin resistance and chronic kidney disease progression, cardiovascular events, and death: findings from the chronic renal insufficiency cohort study
Schrauben SJ, Jepson C, Hsu JY, Wilson FP, Zhang X, Lash JP, Robinson BM, Townsend RR, Chen J, Fogelfeld L, Kao P, Landis JR, Rader DJ, Hamm LL, Anderson AH, Feldman HI. Insulin resistance and chronic kidney disease progression, cardiovascular events, and death: findings from the chronic renal insufficiency cohort study. BMC Nephrology 2019, 20: 60. PMID: 30786864, PMCID: PMC6383235, DOI: 10.1186/s12882-019-1220-6.Peer-Reviewed Original ResearchConceptsChronic kidney disease progressionKidney disease progressionCardiovascular eventsHOMA-IRInsulin resistanceCKD progressionCause mortalityDisease progressionChronic Renal Insufficiency Cohort study participantsChronic Renal Insufficiency Cohort (CRIC) StudyCox proportional hazards modelAbsence of diabetesCohort Study participantsHomeostasis model assessmentProportional hazards modelPositive associationBackgroundInsulin resistanceCKD complicationsCardiovascular endpointsCohort studyHemoglobin A1cMetabolic syndromeKidney diseaseC-peptideHazards model
2016
Clinical Implications of Cluster Analysis-Based Classification of Acute Decompensated Heart Failure and Correlation with Bedside Hemodynamic Profiles
Ahmad T, Desai N, Wilson F, Schulte P, Dunning A, Jacoby D, Allen L, Fiuzat M, Rogers J, Felker GM, O’Connor C, Patel CB. Clinical Implications of Cluster Analysis-Based Classification of Acute Decompensated Heart Failure and Correlation with Bedside Hemodynamic Profiles. PLOS ONE 2016, 11: e0145881. PMID: 26840410, PMCID: PMC4739604, DOI: 10.1371/journal.pone.0145881.Peer-Reviewed Original ResearchConceptsAcute decompensated heart failureDecompensated heart failureHemodynamic profileNon-ischemic cardiomyopathyClinical outcomesADHF patientsHeart failureLower B-type natriuretic peptide levelsB-type natriuretic peptide levelsCox proportional hazards modelConcomitant renal insufficiencyHigher BNP levelsNatriuretic peptide levelsAdverse clinical outcomesBaseline clinical variablesProportional hazards modelBNP levelsAdvanced diseaseCause mortalityMultiple comorbiditiesRenal insufficiencyComorbid conditionsHemodynamic classificationPrognostic valueAdverse outcomes
2014
Urinary Creatinine Excretion, Bioelectrical Impedance Analysis, and Clinical Outcomes in Patients with CKD: The CRIC Study
Wilson FP, Xie D, Anderson AH, Leonard MB, Reese PP, Delafontaine P, Horwitz E, Kallem R, Navaneethan S, Ojo A, Porter AC, Sondheimer JH, Sweeney HL, Townsend RR, Feldman HI, Investigators T. Urinary Creatinine Excretion, Bioelectrical Impedance Analysis, and Clinical Outcomes in Patients with CKD: The CRIC Study. Clinical Journal Of The American Society Of Nephrology 2014, 9: 2095-2103. PMID: 25381342, PMCID: PMC4255402, DOI: 10.2215/cjn.03790414.Peer-Reviewed Original ResearchConceptsLow urinary creatinine excretionUrinary creatinine excretionFat-free massChronic Renal Insufficiency CohortBioelectrical impedance analysisAppendicular lean massClinical outcomesCreatinine excretionLean massSerum cystatin C levelsCox proportional hazards modelLow muscle massChronic disease statesCystatin C levelsDual-energy X-ray absorptiometry assessmentDual-energy X-ray absorptiometry measurementsProportional hazards modelOutcomes of interestCohort of individualsUrinary urea nitrogenCRIC participantsCRIC StudyBlack raceESRDHazards model
2012
Predictors of Death and Dialysis in Severe AKI: The UPHS-AKI Cohort
Wilson FP, Yang W, Feldman HI. Predictors of Death and Dialysis in Severe AKI: The UPHS-AKI Cohort. Clinical Journal Of The American Society Of Nephrology 2012, 8: 527-537. PMID: 23258795, PMCID: PMC3613955, DOI: 10.2215/cjn.06450612.Peer-Reviewed Original ResearchConceptsSevere AKIC-indexIntensive care unit locationPredictors of deathEffective risk stratificationEndpoint of deathMore effective therapeutic interventionsHigh-risk subgroupsHarrell's C-indexLower overall mortalityProportional hazards modelEffective therapeutic interventionsPennsylvania Health SystemBaseline creatinineHospital AKIPressor medicationsSerum creatinineClinical factorsDerivation cohortHigher creatinineHospital admissionOverall mortalityLiver diseaseRisk stratificationValidation cohort