2019
Electronic Alerts for Acute Kidney Injury Amelioration (ELAIA-1): a completely electronic, multicentre, randomised controlled trial: design and rationale
Mutter M, Martin M, Yamamoto Y, Biswas A, Etropolski B, Feldman H, Garg A, Gourlie N, Latham S, Lin H, Palevsky PM, Parikh C, Moreira E, Ugwuowo U, Wilson FP. Electronic Alerts for Acute Kidney Injury Amelioration (ELAIA-1): a completely electronic, multicentre, randomised controlled trial: design and rationale. BMJ Open 2019, 9: e025117. PMID: 31154298, PMCID: PMC6549649, DOI: 10.1136/bmjopen-2018-025117.Peer-Reviewed Original ResearchConceptsAcute kidney injuryElectronic alertsMedical intensive care unitYale-New Haven HospitalDays of randomisationIntensive care unitElectronic alert systemNew Haven HospitalAppropriate ethics committeeElectronic medical record systemAKI alertsAKI progressionAlert specificityInpatient dialysisKidney injuryHospitalised patientsPeer-reviewed journalsUsual careInpatient deathMedical record systemPrimary outcomeCare unitExclusion criteriaOrder setsInformed consent
2017
Association between e-alert implementation for detection of acute kidney injury and outcomes: a systematic review
Lachance P, Villeneuve PM, Rewa OG, Wilson FP, Selby NM, Featherstone RM, Bagshaw SM. Association between e-alert implementation for detection of acute kidney injury and outcomes: a systematic review. Nephrology Dialysis Transplantation 2017, 32: 265-272. PMID: 28088774, PMCID: PMC6251638, DOI: 10.1093/ndt/gfw424.Peer-Reviewed Original ResearchConceptsAcute kidney injuryE-alertsCare processesKidney injuryPooled analysisSystematic reviewRenal replacement therapy usePatient-centered outcomesProcess of careResource utilization measuresElectronic health recordsClinical decision supportHospitalized patientsTherapy useElectronic alertsFluid therapyAlert implementationElectronic databasesRRT utilizationHealth recordsUtilization measuresAvailable studiesOutcomesSignificant differencesGrey literature
2016
Provider acceptance of an automated electronic alert for acute kidney injury
Oh J, Bia JR, Ubaid-Ullah M, Testani JM, Wilson FP. Provider acceptance of an automated electronic alert for acute kidney injury. Clinical Kidney Journal 2016, 9: 567-571. PMID: 27478598, PMCID: PMC4957729, DOI: 10.1093/ckj/sfw054.Peer-Reviewed Original ResearchAcute kidney injuryElectronic alertsAKI alertsKidney injuryPatient careAKI alert systemElectronic AKI alertsNon-physician providersPercent of respondersHealthcare provider opinionsElectronic medical recordsClinical decision support systemMedical recordsSingle hospitalProviders' opinionsProvider acceptanceTrial durationPaucity of informationPatient-specific informationTrialsSignificant differencesAlert trialsInjuryApprovalCareImpact of e-alert for detection of acute kidney injury on processes of care and outcomes: protocol for a systematic review and meta-analysis
Lachance P, Villeneuve PM, Wilson FP, Selby NM, Featherstone R, Rewa O, Bagshaw SM. Impact of e-alert for detection of acute kidney injury on processes of care and outcomes: protocol for a systematic review and meta-analysis. BMJ Open 2016, 6: e011152. PMID: 27150187, PMCID: PMC4861089, DOI: 10.1136/bmjopen-2016-011152.Peer-Reviewed Original ResearchConceptsAcute kidney injuryE-alertsProcess of careElectronic medical recordsSystematic reviewKidney injuryClinical information systemsEpisode of AKIConsiderable health resourcesPooled effect estimatesHealth resource useHealth service usePatient-centered outcomesGrey literature sourcesResearch ethics approvalMajor morbidityCommon complicationClinical outcomesElectronic alertsPooled analysisMedical recordsPatient outcomesService usePrimary analysisElectronic databases
2015
Automated, electronic alerts for acute kidney injury: a single-blind, parallel-group, randomised controlled trial
Wilson FP, Shashaty M, Testani J, Aqeel I, Borovskiy Y, Ellenberg SS, Feldman HI, Fernandez H, Gitelman Y, Lin J, Negoianu D, Parikh CR, Reese PP, Urbani R, Fuchs B. Automated, electronic alerts for acute kidney injury: a single-blind, parallel-group, randomised controlled trial. The Lancet 2015, 385: 1966-1974. PMID: 25726515, PMCID: PMC4475457, DOI: 10.1016/s0140-6736(15)60266-5.Peer-Reviewed Original ResearchConceptsAcute kidney injuryUsual care groupKidney injuryCare groupAlert groupClinical outcomesElectronic alertsEligible participantsKidney Disease Improving Global OutcomesEnd-stage renal diseaseAcute kidney injury alertsEffective treatment optionIntensive care unitElectronic alert systemComputer-generated sequenceRandomisation strataSurgical admissionsUsual carePrimary outcomeRenal diseaseCare unitTreatment optionsCreatinine valuesCreatinine concentrationSuch injuries
2014
A trial of in-hospital, electronic alerts for acute kidney injury: Design and rationale
Wilson FP, Reese PP, Shashaty MG, Ellenberg SS, Gitelman Y, Bansal AD, Urbani R, Feldman HI, Fuchs B. A trial of in-hospital, electronic alerts for acute kidney injury: Design and rationale. Clinical Trials 2014, 11: 521-529. PMID: 25023200, PMCID: PMC4156885, DOI: 10.1177/1740774514542619.Peer-Reviewed Original ResearchConceptsAcute kidney injuryKidney injuryElectronic alert systemHospitalized patientsElectronic alertsInformed consentStage 1 acute kidney injuryStage 3 acute kidney injuryAcute kidney injury severityStudy outcomesAcute kidney injury alertsLow-risk interventionBroad inclusion criteriaInpatient mortalitySerum creatinineMedical recordsClinical trialsPatient outcomesInclusion criteriaProvider recognitionEarly deathDichotomous outcomesInjury severityPatientsInjury