2024
Aging-dependent loss of functional connectivity in a mouse model of Alzheimer’s disease and reversal by mGluR5 modulator
Mandino F, Shen X, Desrosiers-Grégoire G, O’Connor D, Mukherjee B, Owens A, Qu A, Onofrey J, Papademetris X, Chakravarty M, Strittmatter S, Lake E. Aging-dependent loss of functional connectivity in a mouse model of Alzheimer’s disease and reversal by mGluR5 modulator. Molecular Psychiatry 2024, 1-16. PMID: 39424929, DOI: 10.1038/s41380-024-02779-z.Peer-Reviewed Original ResearchFunctional connectivity deficitsConnectivity deficitsFunctional connectivityBrain connectivityAllosteric modulators of mGluR5Alzheimer's diseaseDefault-mode networkModulation of mGluR5Loss of functional connectivityResting-state fMRIApplication of fMRIWild-type controlsAged AD miceMouse model of Alzheimer's diseaseAD-related changesAD miceModel of Alzheimer's diseaseAssociated with synaptic damageMGluR5 modulationMonths of ageFMRI measurementsAmyloid accumulationDecreased connectivityBrain networksSilent allosteric modulators
2021
A triple-network organization for the mouse brain
Mandino F, Vrooman R, Foo H, Yeow L, Bolton T, Salvan P, Teoh C, Lee C, Beauchamp A, Luo S, Bi R, Zhang J, Lim G, Low N, Sallet J, Gigg J, Lerch J, Mars R, Olivo M, Fu Y, Grandjean J. A triple-network organization for the mouse brain. Molecular Psychiatry 2021, 27: 865-872. PMID: 34650202, PMCID: PMC9054663, DOI: 10.1038/s41380-021-01298-5.Peer-Reviewed Original Research