2024
Propofol vs etomidate for induction prior to invasive mechanical ventilation in patients with acute myocardial infarction
Thomas A, Banna S, Shahu A, Ali T, Schenck C, Patel B, Notarianni A, Phommalinh M, Kochar A, Heck C, van Diepen S, Miller P. Propofol vs etomidate for induction prior to invasive mechanical ventilation in patients with acute myocardial infarction. American Heart Journal 2024, 272: 116-125. PMID: 38554762, DOI: 10.1016/j.ahj.2024.03.013.Peer-Reviewed Original ResearchConceptsAssociated with lower mortalityAcute myocardial infarctionInvasive mechanical ventilationLower mortalityUS national databaseClinical Data BaseMyocardial infarctionIll patient populationLength of stayCritically ill patient populationIn-hospital mortalityInverse probability treatmentOptimal induction agentInduction agentNational databaseClinical outcomesMechanical ventilationProbability treatmentPropensity weightingPatient populationRandomized trialsMortalityUtilization of propofolVentilator daysPropofol group
2022
Clinical Outcomes and Cost Associated With an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump in Patients Presenting With Acute Myocardial Infarction Complicated by Cardiogenic Shock
Miller PE, Bromfield SG, Ma Q, Crawford G, Whitney J, DeVries A, Desai NR. Clinical Outcomes and Cost Associated With an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump in Patients Presenting With Acute Myocardial Infarction Complicated by Cardiogenic Shock. JAMA Internal Medicine 2022, 182: 926-933. PMID: 35849410, PMCID: PMC9295019, DOI: 10.1001/jamainternmed.2022.2735.Peer-Reviewed Original ResearchConceptsIntra-aortic balloon pumpPercutaneous coronary interventionKidney replacement therapyAcute myocardial infarctionCardiogenic shockClinical outcomesLVAD useVentricular assist deviceBalloon pumpRetrospective propensity-matched cohort studyAssist deviceAcute Myocardial Infarction ComplicatedPropensity-matched cohort studyTotal health care costsMyocardial Infarction ComplicatedPropensity-matched analysisPropensity-matched pairsLong-term outcomesRisk of mortalityAdministrative claims dataHealth care costsIABP useIndex admissionCohort studyCoronary intervention
2021
Transition From an Open to Closed Staffing Model in the Cardiac Intensive Care Unit Improves Clinical Outcomes
Miller PE, Chouairi F, Thomas A, Kunitomo Y, Aslam F, Canavan ME, Murphy C, Daggula K, Metkus T, Vallabhajosyula S, Carnicelli A, Katz JN, Desai NR, Ahmad T, Velazquez EJ, Brennan J. Transition From an Open to Closed Staffing Model in the Cardiac Intensive Care Unit Improves Clinical Outcomes. Journal Of The American Heart Association 2021, 10: e018182. PMID: 33412899, PMCID: PMC7955420, DOI: 10.1161/jaha.120.018182.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitIntensive care unitHospital mortalityCare unitCICU mortalityClinical outcomesModern cardiac intensive care unitSurgical intensive care unitTotal hospital chargesSeverity of illnessMultivariable logistic regressionCICU lengthMultivariable adjustmentRespiratory insufficiencyPrimary outcomeUnique admissionsHospital chargesCardiac arrestSubgroup analysisImproved outcomesMortalityLogistic regressionAdmissionClosed unitStaffing models
2020
Prevalence of Noncardiac Multimorbidity in Patients Admitted to Two Cardiac Intensive Care Units and Their Association with Mortality
Miller PE, Thomas A, Breen TJ, Chouairi F, Kunitomo Y, Aslam F, Damluji AA, Anavekar NS, Murphy JG, van Diepen S, Barsness GW, Brennan J, Jentzer J. Prevalence of Noncardiac Multimorbidity in Patients Admitted to Two Cardiac Intensive Care Units and Their Association with Mortality. The American Journal Of Medicine 2020, 134: 653-661.e5. PMID: 33129785, PMCID: PMC8079541, DOI: 10.1016/j.amjmed.2020.09.035.Peer-Reviewed Original ResearchConceptsCritical care therapiesNoncardiac comorbiditiesCICU populationCare therapyLong-term adverse clinical outcomesCardiac intensive care unitIntensive care unit practiceBetter care pathwaysIncreased hospital mortalityNoncardiac organ failureUnique patient admissionsAdverse clinical outcomesIntensive care unitMultivariable logistic regressionLength of stayAcute cardiac illnessCICU patientsHospital mortalityNoncardiac indicationsICU admissionMultivariable adjustmentOrgan failureCare unitClinical outcomesCardiac illness
2019
Clinical Implications of Respiratory Failure in Patients Receiving Durable Left Ventricular Assist Devices for End-Stage Heart Failure
Miller PE, Caraballo C, Ravindra NG, Mezzacappa C, McCullough M, Gruen J, Levin A, Reinhardt S, Ali A, Desai NR, Ahmad T. Clinical Implications of Respiratory Failure in Patients Receiving Durable Left Ventricular Assist Devices for End-Stage Heart Failure. Circulation Heart Failure 2019, 12: e006369. PMID: 31707800, DOI: 10.1161/circheartfailure.119.006369.Peer-Reviewed Original ResearchMeSH KeywordsAgedDisease ProgressionFemaleFrailtyHealth StatusHeart FailureHeart-Assist DevicesHumansIntubation, IntratrachealLungMaleMiddle AgedProsthesis DesignQuality of LifeRecovery of FunctionRegistriesRespiratory InsufficiencyRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeVentricular Function, LeftConceptsMechanically Assisted Circulatory Support profile 1 patientsVentricular assist device implantationProfile 1 patientsAssist device implantationRespiratory failureInteragency RegistryLVAD implantationCirculatory supportDevice implantationMechanically Assisted Circulatory Support profile 1Right ventricular assist device implantationLeft ventricular assist device implantationAdvanced heart failure patientsEnd-stage heart failureMechanically Assisted Circulatory SupportAdvanced heart failure populationHeart failure populationHeart failure patientsLandmark clinical trialsMechanical circulatory supportContinuous-flow LVADVentricular assist devicePostimplant complicationsFailure patientsLVAD placementClinical Practice Patterns in Temporary Mechanical Circulatory Support for Shock in the Critical Care Cardiology Trials Network (CCCTN) Registry
Berg DD, Barnett CF, Kenigsberg BB, Papolos A, Alviar CL, Baird-Zars VM, Barsness GW, Bohula EA, Brennan J, Burke JA, Carnicelli AP, Chaudhry SP, Cremer PC, Daniels LB, DeFilippis AP, Gerber DA, Granger CB, Hollenberg S, Horowitz JM, Gladden JD, Katz JN, Keeley EC, Keller N, Kontos MC, Lawler PR, Menon V, Metkus TS, Miller PE, Nativi-Nicolau J, Newby LK, Park JG, Phreaner N, Roswell RO, Schulman SP, Sinha SS, Snell RJ, Solomon MA, Teuteberg JJ, Tymchak W, van Diepen S, Morrow DA. Clinical Practice Patterns in Temporary Mechanical Circulatory Support for Shock in the Critical Care Cardiology Trials Network (CCCTN) Registry. Circulation Heart Failure 2019, 12: e006635. PMID: 31707801, PMCID: PMC7008928, DOI: 10.1161/circheartfailure.119.006635.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiologistsCoronary Care UnitsExtracorporeal Membrane OxygenationFemaleHealthcare DisparitiesHeart-Assist DevicesHemodynamicsHumansIntra-Aortic Balloon PumpingMaleMiddle AgedNorth AmericaPatient AdmissionPractice Patterns, Physicians'Recovery of FunctionRisk FactorsSeverity of Illness IndexShock, CardiogenicTime FactorsTreatment OutcomeConceptsIntraaortic balloon pumpTemporary MCSCardiogenic shockIllness severityBalloon pumpPractice patternsAcute myocardial infarction-related cardiogenic shockCritical Care Cardiology Trials Network RegistryLower Sequential Organ Failure Assessment scoresSequential Organ Failure Assessment scoreTemporary mechanical circulatory support devicesVeno-arterial extracorporeal membrane oxygenationIntraaortic balloon pump useOrgan Failure Assessment scoreTemporary mechanical circulatory supportCardiac intensive care unitInfarction-related cardiogenic shockMechanical circulatory support devicesOverall practice patternsTemporary MCS devicesExtracorporeal membrane oxygenationSevere metabolic derangementHospital-level variationIntensive care unitMechanical circulatory supportNational Trends in Incidence and Outcomes of Patients With Heart Failure Requiring Respiratory Support
Miller PE, Patel S, Saha A, Guha A, Pawar S, Poojary P, Ratnani P, Chan L, Kamholz SL, Alviar CL, van Diepen S, Nasir K, Ahmad T, Nadkarni GN, Desai NR. National Trends in Incidence and Outcomes of Patients With Heart Failure Requiring Respiratory Support. The American Journal Of Cardiology 2019, 124: 1712-1719. PMID: 31585698, DOI: 10.1016/j.amjcard.2019.08.033.Peer-Reviewed Original ResearchConceptsInvasive mechanical ventilationUse of NIVRespiratory support strategiesNoninvasive ventilationHeart failureHospital mortalityRespiratory supportOutcomes of patientsNational Inpatient SampleLength of stayHF hospitalizationIMV groupHF patientsNIV groupRespiratory failureMechanical ventilationHospital chargesInpatient SamplePrimary diagnosisHospital costsMedical complexityPatientsSupport strategiesStudy periodMortality
2016
Angiotensin II antagonism is associated with reduced risk for gastrointestinal bleeding caused by arteriovenous malformations in patients with left ventricular assist devices
Houston BA, Schneider AL, Vaishnav J, Cromwell DM, Miller PE, Faridi KF, Shah A, Sciortino C, Whitman G, Tedford RJ, Stevens GR, Judge DP, Russell SD, Rouf R. Angiotensin II antagonism is associated with reduced risk for gastrointestinal bleeding caused by arteriovenous malformations in patients with left ventricular assist devices. The Journal Of Heart And Lung Transplantation 2016, 36: 380-385. PMID: 28169115, DOI: 10.1016/j.healun.2016.12.016.Peer-Reviewed Original ResearchConceptsLeft ventricular assist deviceGastrointestinal bleedingAngiotensin II antagonismARB therapyVascular endothelial growth factorArteriovenous malformationsVentricular assist deviceAssist deviceAngiotensin receptor blocker therapyContinuous-flow Left Ventricular Assist DevicesAssociation of ACEIReceptor blocker therapyInternational normalized ratioRegression hazard modelGastrointestinal arteriovenous malformationsJohns Hopkins HospitalLogistic regression analysisRisk of AVMAngiotensin II SignalingEndothelial growth factorBlocker therapyRenal functionAdult patientsBlood pressureCardiomyopathy etiologyAssociations of Preimplant Red Blood Cell Distribution Width with Clinical Outcomes Among Individuals with Left Ventricular Assist Devices
Miller PE, Houston BA, Schneider AL, Bush AL, Whitman GJ, Stevens GR, Tedford RJ, Russell SD. Associations of Preimplant Red Blood Cell Distribution Width with Clinical Outcomes Among Individuals with Left Ventricular Assist Devices. ASAIO Journal 2016, 62: 677-683. PMID: 27798492, DOI: 10.1097/mat.0000000000000431.Peer-Reviewed Original ResearchConceptsRed blood cell distribution widthCell distribution widthVentricular assist deviceHeart failureClinical outcomesAssist deviceEnd-stage heart failureDistribution widthPost-LVAD complicationsContinuous-flow LVADProportional hazards modelPostimplant mortalityRDW tertilesGastrointestinal bleedAdverse eventsSecondary outcomesLaboratory variablesLVAD populationFull adjustmentPrognostic abilityHigh riskHazards modelBiologic mechanismsMortalityTertileFrom Dancing to Debilitated
Solomon C, Houston B, Miller P, Rooper L, Scheel P, Gelber A. From Dancing to Debilitated. New England Journal Of Medicine 2016, 374: 470-477. PMID: 26840137, DOI: 10.1056/nejmcps1311794.Peer-Reviewed Case Reports and Technical Notes
2014
A Patient With Systolic Dysfunction and an Alternating Axis
Miller PE, Scholten EL, Desai CS, Tedford RJ. A Patient With Systolic Dysfunction and an Alternating Axis. JAMA Internal Medicine 2014, 174: 2027-2028. PMID: 25347012, DOI: 10.1001/jamainternmed.2014.5452.Peer-Reviewed Case Reports and Technical NotesDahl's Sign
Miller PE, Houston BA. Dahl's Sign. New England Journal Of Medicine 2014, 371: 357. PMID: 25054719, DOI: 10.1056/nejmicm1309904.Peer-Reviewed Case Reports and Technical Notes
2011
Return of the usual suspect
Miller PE, Zurflu E, Jaipaul CK. Return of the usual suspect. The Lancet 2011, 377: 2150. PMID: 21684385, DOI: 10.1016/s0140-6736(11)60443-1.Peer-Reviewed Case Reports and Technical Notes