2024
Propofol vs etomidate for induction prior to invasive mechanical ventilation in patients with acute myocardial infarction
Thomas A, Banna S, Shahu A, Ali T, Schenck C, Patel B, Notarianni A, Phommalinh M, Kochar A, Heck C, van Diepen S, Miller P. Propofol vs etomidate for induction prior to invasive mechanical ventilation in patients with acute myocardial infarction. American Heart Journal 2024, 272: 116-125. PMID: 38554762, DOI: 10.1016/j.ahj.2024.03.013.Peer-Reviewed Original ResearchConceptsAssociated with lower mortalityAcute myocardial infarctionInvasive mechanical ventilationLower mortalityUS national databaseClinical Data BaseMyocardial infarctionIll patient populationLength of stayCritically ill patient populationIn-hospital mortalityInverse probability treatmentOptimal induction agentInduction agentNational databaseClinical outcomesMechanical ventilationProbability treatmentPropensity weightingPatient populationRandomized trialsMortalityUtilization of propofolVentilator daysPropofol group
2023
Exposure to Arterial Hyperoxia During Extracorporeal Membrane Oxygenator Support and Mortality in Patients With Cardiogenic Shock
Jentzer J, Miller P, Alviar C, Yalamuri S, Bohman J, Tonna J. Exposure to Arterial Hyperoxia During Extracorporeal Membrane Oxygenator Support and Mortality in Patients With Cardiogenic Shock. Circulation Heart Failure 2023, 16: e010328. PMID: 36871240, PMCID: PMC10121893, DOI: 10.1161/circheartfailure.122.010328.Peer-Reviewed Original ResearchMeSH KeywordsHeart FailureHospital MortalityHumansHyperoxiaHypertensionOxygenOxygenators, MembraneRetrospective StudiesShock, CardiogenicConceptsExtracorporeal membrane oxygenator supportMembrane oxygenator supportHospital mortalityCardiogenic shockVenoarterial ECMOSevere hyperoxiaMild hyperoxiaHigher PaO2Extracorporeal Life Support Organization registryHigher arterial partial pressureHours of ECMOVenoarterial ECMO supportMultivariable logistic regressionArterial partial pressureClinical trial dataAcid-base statusArterial hyperoxiaExtracorporeal CPRRegistry patientsECMO supportAirway pressureNormal PaO2Ventilatory statusClinical variablesCS patients
2022
Characteristics, therapies, and outcomes of In-Hospital vs Out-of-Hospital cardiac arrest in patients presenting to cardiac intensive care units: From the critical care Cardiology trials network (CCCTN)
Carnicelli A, Keane R, Brown K, Loriaux D, Kendsersky P, Alviar C, Arps K, Berg D, Bohula E, Burke J, Dixson J, Gerber D, Goldfarb M, Granger C, Guo J, Harrison R, Kontos M, Lawler P, Miller P, Nativi-Nicolau J, Newby L, Racharla L, Roswell R, Shah K, Sinha S, Solomon M, Teuteberg J, Wong G, van Diepen S, Katz J, Morrow D. Characteristics, therapies, and outcomes of In-Hospital vs Out-of-Hospital cardiac arrest in patients presenting to cardiac intensive care units: From the critical care Cardiology trials network (CCCTN). Resuscitation 2022, 183: 109664. PMID: 36521683, PMCID: PMC9899313, DOI: 10.1016/j.resuscitation.2022.12.002.Peer-Reviewed Original ResearchMeSH KeywordsCardiologyCardiopulmonary ResuscitationComaCritical CareHospitalsHumansIntensive Care UnitsOut-of-Hospital Cardiac ArrestRetrospective StudiesConceptsCardiac intensive care unitCritical Care Cardiology Trials NetworkOutcome of admissionIntensive care unitCardiac arrestCare unitContemporary cardiac intensive care unitsTertiary cardiac intensive care unitsTrials NetworkLower lactateLower crude mortalityRenal replacement therapyMechanical circulatory supportHospital cardiac arrestHospital mortalityIHCA patientsInvasive hemodynamicsCICU admissionIn-HospitalCoronary diseaseCrude mortalityHeart failureOHCA patientsAtrial fibrillationCirculatory supportClinical Outcomes and Cost Associated With an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump in Patients Presenting With Acute Myocardial Infarction Complicated by Cardiogenic Shock
Miller PE, Bromfield SG, Ma Q, Crawford G, Whitney J, DeVries A, Desai NR. Clinical Outcomes and Cost Associated With an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump in Patients Presenting With Acute Myocardial Infarction Complicated by Cardiogenic Shock. JAMA Internal Medicine 2022, 182: 926-933. PMID: 35849410, PMCID: PMC9295019, DOI: 10.1001/jamainternmed.2022.2735.Peer-Reviewed Original ResearchConceptsIntra-aortic balloon pumpPercutaneous coronary interventionKidney replacement therapyAcute myocardial infarctionCardiogenic shockClinical outcomesLVAD useVentricular assist deviceBalloon pumpRetrospective propensity-matched cohort studyAssist deviceAcute Myocardial Infarction ComplicatedPropensity-matched cohort studyTotal health care costsMyocardial Infarction ComplicatedPropensity-matched analysisPropensity-matched pairsLong-term outcomesRisk of mortalityAdministrative claims dataHealth care costsIABP useIndex admissionCohort studyCoronary interventionPatients With Acute Coronary Syndromes Admitted to Contemporary Cardiac Intensive Care Units: Insights From the CCCTN Registry
Fagundes A, Berg DD, Park JG, Baird-Zars VM, Newby LK, Barsness GW, Miller PE, van Diepen S, Katz JN, Phreaner N, Roswell RO, Menon V, Daniels LB, Morrow DA, Bohula EA, Investigators F. Patients With Acute Coronary Syndromes Admitted to Contemporary Cardiac Intensive Care Units: Insights From the CCCTN Registry. Circulation Cardiovascular Quality And Outcomes 2022, 15: e008652. PMID: 35862019, DOI: 10.1161/circoutcomes.121.008652.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeCoronary Care UnitsHospital MortalityHumansIntensive Care UnitsProspective StudiesRegistriesRetrospective StudiesConceptsCardiac intensive care unitAcute coronary syndromeContemporary cardiac intensive care unitsIntensive care unitCICU admissionAdmission indicationsCICU mortalityCoronary syndromeCare unitPrimary diagnosisIntensive care unit therapyEpidemiology of patientsNon-ACS diagnosisLow-risk patientsTime of admissionCICU lengthAcute severityVasoactive therapyPatient characteristicsRespiratory insufficiencyRisk patientsCommon indicationRoutine admissionACS admissionsProspective studyStaffing models in the cardiac intensive care unit
Quien M, Thomas A, Ludmir J, Miller PE. Staffing models in the cardiac intensive care unit. Current Opinion In Critical Care 2022, 28: 453-459. PMID: 35757936, DOI: 10.1097/mcc.0000000000000958.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsCritical CareCritical IllnessHospital MortalityHumansIntensive Care UnitsRetrospective StudiesUnited StatesWorkforceConceptsCardiac intensive care unitIntensive care unitCare unitContemporary cardiac intensive care unitsModern cardiac intensive care unitMechanical circulatory supportSick patient populationFuture multicenter studiesStaffing modelsPreponderance of dataShock teamRespiratory failureIll patientsCirculatory supportMulticenter studyCardiac arrestPatient populationCardiac intensivistsIll populationMortalityRecent evidenceIntensivistsPatientsRecent dataPopulation
2021
Mechanical ventilation at the time of heart transplantation and associations with clinical outcomes
Miller PE, Mullan CW, Chouairi F, Sen S, Clark KA, Reinhardt S, Fuery M, Anwer M, Geirsson A, Formica R, Rogers JG, Desai NR, Ahmad T. Mechanical ventilation at the time of heart transplantation and associations with clinical outcomes. European Heart Journal Acute Cardiovascular Care 2021, 10: 843-851. PMID: 34389855, PMCID: PMC8557439, DOI: 10.1093/ehjacc/zuab063.Peer-Reviewed Original ResearchMeSH KeywordsAdultDatabases, FactualHeart TransplantationHumansLogistic ModelsOdds RatioRespiration, ArtificialRetrospective StudiesConceptsHeart transplantationMechanical ventilationSingle-organ heart transplantationMedian waitlist timeOrgan Sharing databaseTime of transplantationMultivariable logistic regressionMultivariable adjustmentWaitlist timeClinical outcomesSharing databasePoor outcomeVentilated patientsUnited NetworkTemporary mechanical supportClinical acuityTransplantationPatientsPrevious dialysisLogistic regressionMortalityStrong associationReasonable outcomesOutcomesAssociationThe association between cardiac intensive care unit mechanical ventilation volumes and in-hospital mortality
Nandiwada S, Islam S, Jentzer JC, Miller PE, Fordyce CB, Lawler P, Alviar CL, Sun LY, Dover DC, Lopes RD, Kaul P, van Diepen S. The association between cardiac intensive care unit mechanical ventilation volumes and in-hospital mortality. European Heart Journal Acute Cardiovascular Care 2021, 10: 797-805. PMID: 34318875, PMCID: PMC9067446, DOI: 10.1093/ehjacc/zuab055.Peer-Reviewed Original ResearchMeSH KeywordsCoronary Care UnitsHospital MortalityHumansIntensive Care UnitsLength of StayPercutaneous Coronary InterventionRespiration, ArtificialRetrospective StudiesConceptsCardiac intensive care unitMechanical ventilationHospital mortalityRespiratory failureCICU LOSNon-invasive mechanical ventilationNational population-based dataInvasive mechanical ventilationVolume-mortality relationshipProlonged mechanical ventilationProportion of patientsHigh-volume hospitalsPercutaneous coronary interventionLow-volume centersHigh-volume centersIntensive care unitPopulation-based dataOutcomes of interestCICU lengthCICU admissionCoronary interventionSurgical ICUCare unitVolume centersLower incidenceTransition From an Open to Closed Staffing Model in the Cardiac Intensive Care Unit Improves Clinical Outcomes
Miller PE, Chouairi F, Thomas A, Kunitomo Y, Aslam F, Canavan ME, Murphy C, Daggula K, Metkus T, Vallabhajosyula S, Carnicelli A, Katz JN, Desai NR, Ahmad T, Velazquez EJ, Brennan J. Transition From an Open to Closed Staffing Model in the Cardiac Intensive Care Unit Improves Clinical Outcomes. Journal Of The American Heart Association 2021, 10: e018182. PMID: 33412899, PMCID: PMC7955420, DOI: 10.1161/jaha.120.018182.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitIntensive care unitHospital mortalityCare unitCICU mortalityClinical outcomesModern cardiac intensive care unitSurgical intensive care unitTotal hospital chargesSeverity of illnessMultivariable logistic regressionCICU lengthMultivariable adjustmentRespiratory insufficiencyPrimary outcomeUnique admissionsHospital chargesCardiac arrestSubgroup analysisImproved outcomesMortalityLogistic regressionAdmissionClosed unitStaffing models
2020
Prevalence of Noncardiac Multimorbidity in Patients Admitted to Two Cardiac Intensive Care Units and Their Association with Mortality
Miller PE, Thomas A, Breen TJ, Chouairi F, Kunitomo Y, Aslam F, Damluji AA, Anavekar NS, Murphy JG, van Diepen S, Barsness GW, Brennan J, Jentzer J. Prevalence of Noncardiac Multimorbidity in Patients Admitted to Two Cardiac Intensive Care Units and Their Association with Mortality. The American Journal Of Medicine 2020, 134: 653-661.e5. PMID: 33129785, PMCID: PMC8079541, DOI: 10.1016/j.amjmed.2020.09.035.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Care UnitsFemaleHospital MortalityHumansLength of StayMaleMiddle AgedMultimorbidityPrevalenceRetrospective StudiesTertiary Care CentersConceptsCritical care therapiesNoncardiac comorbiditiesCICU populationCare therapyLong-term adverse clinical outcomesCardiac intensive care unitIntensive care unit practiceBetter care pathwaysIncreased hospital mortalityNoncardiac organ failureUnique patient admissionsAdverse clinical outcomesIntensive care unitMultivariable logistic regressionLength of stayAcute cardiac illnessCICU patientsHospital mortalityNoncardiac indicationsICU admissionMultivariable adjustmentOrgan failureCare unitClinical outcomesCardiac illness
2019
Clinical Implications of Respiratory Failure in Patients Receiving Durable Left Ventricular Assist Devices for End-Stage Heart Failure
Miller PE, Caraballo C, Ravindra NG, Mezzacappa C, McCullough M, Gruen J, Levin A, Reinhardt S, Ali A, Desai NR, Ahmad T. Clinical Implications of Respiratory Failure in Patients Receiving Durable Left Ventricular Assist Devices for End-Stage Heart Failure. Circulation Heart Failure 2019, 12: e006369. PMID: 31707800, DOI: 10.1161/circheartfailure.119.006369.Peer-Reviewed Original ResearchMeSH KeywordsAgedDisease ProgressionFemaleFrailtyHealth StatusHeart FailureHeart-Assist DevicesHumansIntubation, IntratrachealLungMaleMiddle AgedProsthesis DesignQuality of LifeRecovery of FunctionRegistriesRespiratory InsufficiencyRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeVentricular Function, LeftConceptsMechanically Assisted Circulatory Support profile 1 patientsVentricular assist device implantationProfile 1 patientsAssist device implantationRespiratory failureInteragency RegistryLVAD implantationCirculatory supportDevice implantationMechanically Assisted Circulatory Support profile 1Right ventricular assist device implantationLeft ventricular assist device implantationAdvanced heart failure patientsEnd-stage heart failureMechanically Assisted Circulatory SupportAdvanced heart failure populationHeart failure populationHeart failure patientsLandmark clinical trialsMechanical circulatory supportContinuous-flow LVADVentricular assist devicePostimplant complicationsFailure patientsLVAD placementNational Trends in Incidence and Outcomes of Patients With Heart Failure Requiring Respiratory Support
Miller PE, Patel S, Saha A, Guha A, Pawar S, Poojary P, Ratnani P, Chan L, Kamholz SL, Alviar CL, van Diepen S, Nasir K, Ahmad T, Nadkarni GN, Desai NR. National Trends in Incidence and Outcomes of Patients With Heart Failure Requiring Respiratory Support. The American Journal Of Cardiology 2019, 124: 1712-1719. PMID: 31585698, DOI: 10.1016/j.amjcard.2019.08.033.Peer-Reviewed Original ResearchConceptsInvasive mechanical ventilationUse of NIVRespiratory support strategiesNoninvasive ventilationHeart failureHospital mortalityRespiratory supportOutcomes of patientsNational Inpatient SampleLength of stayHF hospitalizationIMV groupHF patientsNIV groupRespiratory failureMechanical ventilationHospital chargesInpatient SamplePrimary diagnosisHospital costsMedical complexityPatientsSupport strategiesStudy periodMortality
2016
Angiotensin II antagonism is associated with reduced risk for gastrointestinal bleeding caused by arteriovenous malformations in patients with left ventricular assist devices
Houston BA, Schneider AL, Vaishnav J, Cromwell DM, Miller PE, Faridi KF, Shah A, Sciortino C, Whitman G, Tedford RJ, Stevens GR, Judge DP, Russell SD, Rouf R. Angiotensin II antagonism is associated with reduced risk for gastrointestinal bleeding caused by arteriovenous malformations in patients with left ventricular assist devices. The Journal Of Heart And Lung Transplantation 2016, 36: 380-385. PMID: 28169115, DOI: 10.1016/j.healun.2016.12.016.Peer-Reviewed Original ResearchConceptsLeft ventricular assist deviceGastrointestinal bleedingAngiotensin II antagonismARB therapyVascular endothelial growth factorArteriovenous malformationsVentricular assist deviceAssist deviceAngiotensin receptor blocker therapyContinuous-flow Left Ventricular Assist DevicesAssociation of ACEIReceptor blocker therapyInternational normalized ratioRegression hazard modelGastrointestinal arteriovenous malformationsJohns Hopkins HospitalLogistic regression analysisRisk of AVMAngiotensin II SignalingEndothelial growth factorBlocker therapyRenal functionAdult patientsBlood pressureCardiomyopathy etiologyAssociations of Preimplant Red Blood Cell Distribution Width with Clinical Outcomes Among Individuals with Left Ventricular Assist Devices
Miller PE, Houston BA, Schneider AL, Bush AL, Whitman GJ, Stevens GR, Tedford RJ, Russell SD. Associations of Preimplant Red Blood Cell Distribution Width with Clinical Outcomes Among Individuals with Left Ventricular Assist Devices. ASAIO Journal 2016, 62: 677-683. PMID: 27798492, DOI: 10.1097/mat.0000000000000431.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedErythrocyte IndicesFemaleHeart-Assist DevicesHumansMaleMiddle AgedProportional Hazards ModelsRetrospective StudiesConceptsRed blood cell distribution widthCell distribution widthVentricular assist deviceHeart failureClinical outcomesAssist deviceEnd-stage heart failureDistribution widthPost-LVAD complicationsContinuous-flow LVADProportional hazards modelPostimplant mortalityRDW tertilesGastrointestinal bleedAdverse eventsSecondary outcomesLaboratory variablesLVAD populationFull adjustmentPrognostic abilityHigh riskHazards modelBiologic mechanismsMortalityTertile