2014
High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II
Sverdlov AL, Elezaby A, Behring JB, Bachschmid MM, Luptak I, Tu VH, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Colucci WS. High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II. Journal Of Molecular And Cellular Cardiology 2014, 78: 165-173. PMID: 25109264, PMCID: PMC4268348, DOI: 10.1016/j.yjmcc.2014.07.018.Peer-Reviewed Original ResearchConceptsCysteine oxidative post-translational modificationsOxidative post-translational modificationsCardiac mitochondrial proteinsPost-translational modificationsMetabolic heart diseaseMitochondrial proteinsATP synthesisMitochondrial dysfunctionBasic Mitochondrial BiologyCardiac mitochondriaMitochondrial biologyOxidative stressTag labelingCardiac mitochondrial dysfunctionBiotin switchSubunit AATP productionMitochondrial ROSGSH/GSSG ratioFunctional consequencesMitochondriaReversible oxidationGSSG ratioProteinSDHA
2012
Cardiac-Specific Fatty Acid Transport Protein 1 (FATP1) Overexpression Causes Decreased Mitochondrial Respiration, Increased Oxidative Stress and Activation of AMPK
Elezaby A, Miller E, Qin F, Liesa M, Shirihai O, Colucci W. Cardiac-Specific Fatty Acid Transport Protein 1 (FATP1) Overexpression Causes Decreased Mitochondrial Respiration, Increased Oxidative Stress and Activation of AMPK. Free Radical Biology And Medicine 2012, 53: s159. DOI: 10.1016/j.freeradbiomed.2012.10.434.Peer-Reviewed Original ResearchThe Polyphenols Resveratrol and S17834 Prevent the Structural and Functional Sequelae of Diet-Induced Metabolic Heart Disease in Mice
Qin F, Siwik DA, Luptak I, Hou X, Wang L, Higuchi A, Weisbrod RM, Ouchi N, Tu VH, Calamaras TD, Miller EJ, Verbeuren TJ, Walsh K, Cohen RA, Colucci WS. The Polyphenols Resveratrol and S17834 Prevent the Structural and Functional Sequelae of Diet-Induced Metabolic Heart Disease in Mice. Circulation 2012, 125: 1757-1764. PMID: 22388319, PMCID: PMC3354628, DOI: 10.1161/circulationaha.111.067801.Peer-Reviewed Original ResearchConceptsHFHS diet-fed miceDiet-fed miceMetabolic heart diseaseDiastolic dysfunctionLeft ventricular hypertrophyMyocardial oxidative stressVentricular hypertrophyHeart diseaseInterstitial fibrosisPlasma adiponectinInsulin resistanceProgressive left ventricular hypertrophyDiet-induced metabolic syndromeBeneficial effectsOxidative stressHomeostasis model assessmentMale C57BL/6J miceChronic hemodynamic overloadHFHS dietCardiovascular effectsSystolic functionDiabetes mellitusMetabolic syndromeConcomitant treatmentHemodynamic overload