2017
There is inadequate evidence to support the division of the genus Borrelia
Margos G, Marosevic D, Cutler S, Derdakova M, Diuk-Wasser M, Emler S, Fish D, Gray J, Hunfeldt K, Jaulhac B, Kahl O, Kovalev S, Kraiczy P, Lane R, Lienhard R, Lindgren P, Ogden N, Ornstein K, Rupprecht T, Schwartz I, Sing A, Straubinger R, Strle F, Voordouw M, Rizzoli A, Stevenson B, Fingerle V. There is inadequate evidence to support the division of the genus Borrelia. International Journal Of Systematic And Evolutionary Microbiology 2017, 67: 1081-1084. PMID: 27930271, DOI: 10.1099/ijsem.0.001717.Peer-Reviewed Original Research
2008
MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi
Margos G, Gatewood A, Aanensen D, Hanincová K, Terekhova D, Vollmer S, Cornet M, Piesman J, Donaghy M, Bormane A, Hurn M, Feil E, Fish D, Casjens S, Wormser G, Schwartz I, Kurtenbach K. MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 8730-8735. PMID: 18574151, PMCID: PMC2435589, DOI: 10.1073/pnas.0800323105.Peer-Reviewed Original ResearchConceptsHousekeeping genesIntergenic spacerPopulation structureGeographic population structureChromosomal housekeeping genesMultilocus sequence typing (MLST) schemeB. burgdorferiPhylogenetic signalNorth AmericaEvolutionary relationshipsSequence typing schemeEvolutionary trajectoriesIGS locusSequence dataMLST schemeCultured isolatesGenesBorrelia burgdorferiOuter surface protein CMLST dataDistinct populationsSurface protein CBacterium Borrelia burgdorferiEuropean populationsVector-borne diseases
2004
Sequence typing reveals extensive strain diversity of the Lyme borreliosis agents Borrelia burgdorferi in North America and Borrelia afzelii in Europe
Bunikis J, Garpmo U, Tsao J, Berglund J, Fish D, Barbour A. Sequence typing reveals extensive strain diversity of the Lyme borreliosis agents Borrelia burgdorferi in North America and Borrelia afzelii in Europe. Microbiology 2004, 150: 1741-1755. PMID: 15184561, DOI: 10.1099/mic.0.26944-0.Peer-Reviewed Original ResearchConceptsIntergenic spacerGenetic diversityIGS locusIGS genotypesOspC allelesHigh nucleotide diversityDistinct clonal lineagesGreater genetic diversityB. burgdorferiNorth-eastern United StatesTick vector Ixodes scapularisNucleotide diversityMonophyletic lineageSignature nucleotidesPhylogenetic studiesLinkage groupsIGS sequencesPhylogenetic inferenceIntragenic recombinationExtensive strain diversityDetectable recombinationVector Ixodes scapularisClonal lineagesField sitesLoci
2003
Genetic Variability within Borrelia burgdorferi Sensu Lato Genospecies Established by PCR-Single-Strand Conformation Polymorphism Analysis of the rrfA-rrlB Intergenic Spacer in Ixodes ricinus Ticks from the Czech Republic
Derdáková M, Beati L, Pet'ko B, Stanko M, Fish D. Genetic Variability within Borrelia burgdorferi Sensu Lato Genospecies Established by PCR-Single-Strand Conformation Polymorphism Analysis of the rrfA-rrlB Intergenic Spacer in Ixodes ricinus Ticks from the Czech Republic. Applied And Environmental Microbiology 2003, 69: 509-516. PMID: 12514035, PMCID: PMC152394, DOI: 10.1128/aem.69.1.509-516.2003.Peer-Reviewed Original ResearchAnimalsBacterial Typing TechniquesBorrelia burgdorferi GroupCzech RepublicDNA, BacterialDNA, Ribosomal SpacerGenetic VariationGenotypeHumansIxodesMolecular Sequence DataPhylogenyPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthPolymorphism, Single-Stranded ConformationalSequence Analysis, DNA
2000
Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A
Pal U, de Silva A, Montgomery R, Fish D, Anguita J, Anderson J, Lobet Y, Fikrig E. Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A. Journal Of Clinical Investigation 2000, 106: 561-569. PMID: 10953031, PMCID: PMC380253, DOI: 10.1172/jci9427.Peer-Reviewed Original Research