2021
Hepatocellular Carcinoma
Jain A, Mazer B, Deng Y, Ciarleglio M, Jain D, Taddei T, Zhang X. Hepatocellular Carcinoma. American Journal Of Clinical Pathology 2021, 157: 305-313. PMID: 34542582, DOI: 10.1093/ajcp/aqab125.Peer-Reviewed Original ResearchConceptsAnaplastic tumor cellsHepatocellular carcinomaNoncirrhotic liverVascular invasionHistologic patternCirrhotic liverTumor cellsClear cell subtypePathogenesis of HCCHigh histologic gradeLarger tumor sizeHigher tumor stageHigh tumor gradeHigh rateHepatitis BHepatitis CLiver diseaseTumor sizeHistologic gradeTumor stageTumor gradePathologic differencesHCC casesRetrospective analysisPathology archivesCan primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis?
Kumar D, Hafez O, Jain D, Zhang X. Can primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis? Human Pathology 2021, 113: 39-46. PMID: 33905775, DOI: 10.1016/j.humpath.2021.04.008.Peer-Reviewed Original ResearchConceptsMetastatic hepatocellular carcinomaHepatocellular carcinomaHistologic patternHistomorphologic featuresPrimary tumorMetastatic tumorsMacrotrabecular-massive hepatocellular carcinomaCommon histologic patternPathogenesis of metastasisSignificant intratumoral heterogeneityExtrahepatic metastasesLymph nodesMicrovascular invasionAdrenal glandCommon subtypeNoncirrhotic liverCirrhotic liverCommon siteMetastatic tissuesLarge cohortAbdominal cavityHCC subtypesPathology archivesMetastasisHCC metastasis
2019
Cryptogenic cirrhosis: Old and new perspectives in the era of molecular and genomic medicine
Nalbantoglu I, Jain D. Cryptogenic cirrhosis: Old and new perspectives in the era of molecular and genomic medicine. Seminars In Diagnostic Pathology 2019, 36: 389-394. PMID: 31395291, DOI: 10.1053/j.semdp.2019.07.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCryptogenic cirrhosisCC casesLiver diseaseUnknown etiologyMain histologic findingsPossible genetic counselingChronic liver diseaseWhole-exome sequencingCirrhosis casesPediatric patientsTransplant eligibilityHistologic findingsHistologic patternPotential etiologiesHistologic examinationHistologic characterizationGenetic testingEtiologyPatientsExome sequencingDiagnostic abilityGenetic counselingGenetic alterationsDiagnosisNew disorderLymphoproliferative Disorders of the Small and Large Intestine
Celli R, Jain D. Lymphoproliferative Disorders of the Small and Large Intestine. Atlas Of Anatomic Pathology 2019, 111-129. DOI: 10.1007/978-3-030-12379-6_6.Peer-Reviewed Original ResearchDiffuse large B-cell lymphomaLarge intestineLow-grade marginal zone lymphomaT-cell receptor gene rearrangementsLarge B-cell lymphomaCommon extranodal siteMarginal zone lymphomaB-cell lymphomaReceptor gene rearrangementsAncillary diagnostic methodsExtranodal lymphomaExtranodal sitesCommon diagnosisLymphoproliferative disordersHistologic patternLymphoid tissuePolymerase chain reactionGastrointestinal tractImmunological responseGI tractTotal casesB cellsClassic phenotypeClonal proliferationLymphoma
2009
Spectrum of histologic changes in colonic biopsies in patients treated with mycophenolate mofetil
Selbst MK, Ahrens WA, Robert ME, Friedman A, Proctor DD, Jain D. Spectrum of histologic changes in colonic biopsies in patients treated with mycophenolate mofetil. Modern Pathology 2009, 22: 737-743. PMID: 19329937, DOI: 10.1038/modpathol.2009.44.Peer-Reviewed Original ResearchConceptsSolid organ transplant patientsSelf-limited colitisMycophenolate mofetilInflammatory bowel diseaseOrgan transplant patientsColonic biopsiesHistologic changesHost diseaseGastrointestinal symptomsTransplant patientsBowel diseaseArchitectural distortionMycophenolate mofetil usePaneth cell metaplasiaSolid organ transplantationMofetil useInflammatory bowelMucin depletionCell metaplasiaImmunosuppressive agentsInflammatory infiltrateHistologic patternCase reportHistologic spectrumDiagnostic difficulties