2022
Alternative lengthening of telomeres in primary hepatic neoplasms
Yasir S, Thompson S, Chen Z, Knudson R, Knutson D, Kloft-Nelson S, Graham R, Jain D, Simon S, Wu T, Torbenson M. Alternative lengthening of telomeres in primary hepatic neoplasms. Human Pathology 2022, 131: 79-86. PMID: 36370823, PMCID: PMC10756352, DOI: 10.1016/j.humpath.2022.11.003.Peer-Reviewed Original ResearchConceptsPrimary hepatic neoplasmsPrimary hepatic angiosarcomaHepatocellular carcinomaHepatic neoplasmsHepatic angiosarcomaFibrolamellar carcinomaEpithelial tumorsNuclear pleomorphismFrequency of ALTStromal-epithelial tumorPrimary hepatic tumorsHepatocellular carcinoma componentMarked nuclear pleomorphismSoft tissue tumorsRare carcinosarcomaEmbryonal sarcomaEpithelioid hemangioendotheliomaDuct adenomaHilar cholangiocarcinomaCarcinoma componentHepatic adenomaHepatic tumorsTissue tumorsHepatocellular adenomaRhabdoid tumor
2008
Chromosomal changes in fibrolamellar hepatocellular carcinoma detected by array comparative genomic hybridization
Kakar S, Chen X, Ho C, Burgart LJ, Sahai V, Dachrut S, Yabes A, Jain D, Ferrell LD. Chromosomal changes in fibrolamellar hepatocellular carcinoma detected by array comparative genomic hybridization. Modern Pathology 2008, 22: 134-141. PMID: 18997738, DOI: 10.1038/modpathol.2008.178.Peer-Reviewed Original ResearchConceptsConventional hepatocellular carcinomaFibrolamellar hepatocellular carcinomaHepatocellular carcinomaFibrolamellar carcinomaChromosomal abnormalitiesCommon abnormalityChromosomal changesClinicopathologic featuresTumor sizeRare subtypeAbnormal casesHistological featuresFavorable outcomeNormal resultsBetter survivalComparative genomic hybridization analysisCarcinomaCytogenetic abnormalitiesGenomic hybridization analysisAbnormalitiesCytogenetic aberrationsArray comparative genomic hybridizationComparative genomic hybridizationMean numberPatients
2005
Clinicopathologic features and survival in fibrolamellar carcinoma: comparison with conventional hepatocellular carcinoma with and without cirrhosis
Kakar S, Burgart LJ, Batts KP, Garcia J, Jain D, Ferrell LD. Clinicopathologic features and survival in fibrolamellar carcinoma: comparison with conventional hepatocellular carcinoma with and without cirrhosis. Modern Pathology 2005, 18: 1417-1423. PMID: 15920538, DOI: 10.1038/modpathol.3800449.Peer-Reviewed Original ResearchConceptsConventional hepatocellular carcinomaFibrolamellar carcinomaHepatocellular carcinomaClinicopathologic featuresOverall survivalTumor sizeMean Ki-67 indexAbsence of cirrhosisDistinct clinicopathologic featuresKi-67 indexMetastatic diseaseLymph nodesOverall mortalityDistant metastasisNonmetastatic casesPathologic featuresAggressive neoplasmNoncirrhotic liverCirrhotic liverCirrhosisKi-67Better outcomesCarcinomaProliferative activityYoung individuals