2021
Thick Fibrous Septa on Liver Biopsy Specimens Predict the Development of Decompensation in Patients With Compensated Cirrhosis
Jain D, Sreenivasan P, Inayat I, Deng Y, Ciarleglio MM, Garcia-Tsao G. Thick Fibrous Septa on Liver Biopsy Specimens Predict the Development of Decompensation in Patients With Compensated Cirrhosis. American Journal Of Clinical Pathology 2021, 156: 802-809. PMID: 33940622, PMCID: PMC8512277, DOI: 10.1093/ajcp/aqab024.Peer-Reviewed Original ResearchConceptsDevelopment of decompensationThick fibrous septaSeptal widthCompensated cirrhosisClinical decompensationSeptal thicknessFibrous septaEnd-stage liver disease (MELD) scorePrimary end pointSignificant portal hypertensionLiver Disease scoreLiver biopsy specimenLiver biopsy specimensNodule sizeCirrhosis decompensationHistologic cirrhosisCompensated patientsPortal hypertensionIndependent predictorsLiver biopsyCommon etiologyWorse prognosisBiopsy specimenBiopsy specimensUnivariate analysis
2014
Evaluation of Barrett Esophagus by Multiphoton Microscopy
Wong S, Nathanson M, Chen J, Jain D. Evaluation of Barrett Esophagus by Multiphoton Microscopy. Archives Of Pathology & Laboratory Medicine 2014, 138: 204-12. PMID: 24476518, PMCID: PMC4089503, DOI: 10.5858/arpa.2012-0675-oa.Peer-Reviewed Original ResearchMeSH KeywordsAdenine NucleotidesBarrett EsophagusBiopsyCardiaConnecticutEndoscopy, GastrointestinalEsophagogastric JunctionEsophagusGastric FundusGastric MucosaGoblet CellsHospitals, UniversityHumansLasersMaterials TestingMetaplasiaMicroscopy, Fluorescence, MultiphotonMucous MembranePoint-of-Care SystemsSpectroscopy, Near-InfraredConceptsDiagnosis of BEBarrett's esophagusGastroesophageal junctionGoblet cellsColumnar mucosaSquamous mucosaBiopsy specimensNormal esophageal squamous mucosaMPM imagingEndoscopy suiteIntestinal-type columnar epitheliumCardia-type mucosaRoutine upper endoscopyTissue blocksSurveillance of patientsRoutine histopathologic examinationNormal squamous mucosaType of mucosaEsophageal squamous mucosaFresh biopsy specimensMPM imagesSquamous epithelial cellsGastric fundic mucosaMultiphoton microscopyUpper endoscopy
2004
Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis
Dranoff JA, Kruglov EA, Toure J, Braun N, Zimmermann H, Jain D, Knowles AF, Sévigny J. Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis. Journal Of Investigative Medicine 2004, 52: 475. PMID: 15651265, DOI: 10.1136/jim-52-07-42.Peer-Reviewed Original ResearchConceptsBile duct ligationNTPDase2 expressionPrimary biliary cirrhosisBiliary cirrhosisPortal fibroblastsReal-time polymerase chain reactionCCl4 administrationPolymerase chain reactionBiopsy specimensPortal areasExperimental ratsFibrous bandsNormal liverConfocal immunofluorescenceAlpha-smooth muscle actinExpression of NTPDase2Fibrogenic liver cellsHepatitis C cirrhosisLiver biopsy specimensFibrotic liver diseaseHuman liver biopsy specimensChain reactionNew therapeutic approachesHepatic stellate cellsCarbon tetrachloride administrationEctonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis.
Dranoff J, Kruglov E, Toure J, Braun N, Zimmermann H, Jain D, Knowles A, Sévigny J. Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis. Journal Of Investigative Medicine 2004, 52: 475. DOI: 10.1097/00042871-200411000-00042.Peer-Reviewed Original ResearchBile duct ligationNTPDase2 expressionPrimary biliary cirrhosisBiliary cirrhosisPortal fibroblastsReal-time polymerase chain reactionCCl4 administrationPolymerase chain reactionBiopsy specimensPortal areasExperimental ratsFibrous bandsNormal liverConfocal immunofluorescenceExpression of NTPDase2Fibrogenic liver cellsHepatitis C. ConclusionsHepatitis C cirrhosisLiver biopsy specimensFibrotic liver diseaseChain reactionHuman liver biopsy specimensHepatic stellate cellsNew therapeutic approachesSmooth muscle actinEctonucleotidase NTPDase2 is Selectively Down-Regulated in Biliary Cirrhosis
Dranoff J, Kruglov E, Toure J, Braun N, Zimmermann H, Jain D, Knowles A, Sévigny J. Ectonucleotidase NTPDase2 is Selectively Down-Regulated in Biliary Cirrhosis. Journal Of Investigative Medicine 2004, 52: 475-482. DOI: 10.1177/108155890405200741.Peer-Reviewed Original ResearchBile duct ligationNTPDase2 expressionPrimary biliary cirrhosisBiliary cirrhosisPortal fibroblastsReal-time polymerase chain reactionPolymerase chain reactionBiopsy specimensPortal areasExperimental ratsFibrous bandsNormal liverConfocal immunofluorescenceExpression of NTPDase2Fibrogenic liver cellsHepatitis C cirrhosisLiver biopsy specimensFibrotic liver diseaseChain reactionHuman liver biopsy specimensHepatic stellate cellsNew therapeutic approachesSmooth muscle actinCarbon tetrachloride administrationTriphosphate diphosphohydrolase 2Isolated gastric malakoplakia: a case report and review of the literature.
Gustavo LC, Robert ME, Lamps LW, Lagarde SP, Jain D. Isolated gastric malakoplakia: a case report and review of the literature. Archives Of Pathology & Laboratory Medicine 2004, 128: e153-6. PMID: 15504079, DOI: 10.5858/2004-128-e153-igmacr.Peer-Reviewed Original ResearchConceptsBiopsy specimensMultiple small polypoid lesionsOccult bacterial infectionUpper gastrointestinal endoscopyExamination 12 monthsSmall polypoid lesionsHelicobacter pylori infectionMichaelis-Gutmann bodiesYersinia pseudotuberculosis infectionFundic gland polypsEosinophilic granular cytoplasmAfrican American womenConcurrent malignancyGastrointestinal malakoplakiaHistologic improvementGastric involvementGastric bodyClinical evidencePolypoid lesionsPylori infectionH pyloriHistologic findingsCase reportGastrointestinal endoscopyPolymerase chain reaction