2002
Molecular basis of sequence‐specific single‐stranded DNA recognition by KH domains: solution structure of a complex between hnRNP K KH3 and single‐stranded DNA
Braddock DT, Baber JL, Levens D, Clore GM. Molecular basis of sequence‐specific single‐stranded DNA recognition by KH domains: solution structure of a complex between hnRNP K KH3 and single‐stranded DNA. The EMBO Journal 2002, 21: 3476-3485. PMID: 12093748, PMCID: PMC126100, DOI: 10.1093/emboj/cdf352.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAmino Acid SequenceBase SequenceCrystallography, X-RayDNA HelicasesDNA, Single-StrandedDNA-Binding ProteinsHeterogeneous-Nuclear Ribonucleoprotein KHeterogeneous-Nuclear RibonucleoproteinsHumansHydrogen BondingModels, MolecularMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularNucleic Acid ConformationProtein BindingProtein ConformationProtein Structure, TertiaryRibonucleoproteinsRNA-Binding ProteinsSequence AlignmentSequence Homology, Amino AcidSolutionsSubstrate SpecificityConceptsKH domainsDNA recognitionHeterogeneous nuclear ribonucleoprotein KK homology domainSolution structureProtein-ssDNA complexResidues N-terminalHomology domainKH3 domainGXXG motifKH4 domainsMolecular basisN-terminalCytosine basesIsoleucine residueAmino acidsKH3Crucial roleComplexesTetradsDomainDNAMotifMethyl groupResidues
2001
Rapid Identification of Medium- to Large-Scale Interdomain Motion in Modular Proteins Using Dipolar Couplings
Braddock D, Cai M, Baber J, Huang Y, Clore G. Rapid Identification of Medium- to Large-Scale Interdomain Motion in Modular Proteins Using Dipolar Couplings. Journal Of The American Chemical Society 2001, 123: 8634-8635. PMID: 11525687, DOI: 10.1021/ja016234f.Peer-Reviewed Original ResearchMeSH KeywordsDNADNA-Binding ProteinsMembrane ProteinsNuclear Magnetic Resonance, BiomolecularNuclear ProteinsProtein FoldingProtein Structure, TertiaryConceptsLarge-scale interdomain motions
1998
Structure−Function Relationships in Side Chain Lactam Cross-Linked Peptide Models of a Conserved N-Terminal Domain of Apolipoprotein E †
Benzinger T, Braddock D, Dominguez S, Burkoth T, Miller-Auer H, Subramanian R, Fless G, Jones D, Lynn D, Meredith S. Structure−Function Relationships in Side Chain Lactam Cross-Linked Peptide Models of a Conserved N-Terminal Domain of Apolipoprotein E †. Biochemistry 1998, 37: 13222-13229. PMID: 9748329, DOI: 10.1021/bi980482f.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApolipoproteins ECell LineCircular DichroismConserved SequenceEmbryo, MammalianFibroblastsIodine RadioisotopesLactamsMiceModels, MolecularMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProtein Structure, SecondaryReceptors, LDLStructure-Activity RelationshipConceptsPeptide IVPeptide modelsConformational switchSide chain lactamLipid surfaceSide chainsBioactive peptidesStructural orderMultiple conformationsBiological activityStructure-function relationshipsLactamsAlpha-helixStrategic modificationsSecondary structureHelical segmentsPeptide IIIConformationAlpha-helical segmentsShort alpha helixCOOHHelixAntipodeStructureSolution