2019
Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients
Jain K, Tyagi T, Patell K, Xie Y, Kadado AJ, Lee SH, Yarovinsky T, Du J, Hwang J, Martin KA, Testani J, Ionescu CN, Hwa J. Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients. EBioMedicine 2019, 44: 28-40. PMID: 31130473, PMCID: PMC6604369, DOI: 10.1016/j.ebiom.2019.05.022.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAge FactorsAgedAged, 80 and overAgingAnimalsAntioxidantsApoptosisBiomarkersBlood PlateletsCardiovascular DiseasesComorbidityDisease Models, AnimalFemaleHomeostasisHumansMaleMiceMiddle AgedOxidation-ReductionOxidative StressPlatelet ActivationPlatelet AdhesivenessReactive Oxygen SpeciesRisk AssessmentRisk FactorsConceptsRisk patientsMouse studiesPlatelet phenotypeMajor adverse cardiovascular eventsHigh cardiovascular risk patientsAdaptive increaseAdverse cardiovascular eventsCentral pathophysiological roleCVD risk patientsCardiovascular risk patientsAggressive antiplatelet therapyEffect of comorbidityAge group 40Young healthy subjectsAntiplatelet therapyCardiovascular eventsYear age cohortAdvanced ageCVD patientsGroup 40Healthy subjectsPathophysiological roleElderly populationCardiovascular pathologyPatientsAntiplatelet therapy for tibial balloon angioplasty: A clinical perspective
Ionescu CN, Altin SE, Mena-Hurtado C. Antiplatelet therapy for tibial balloon angioplasty: A clinical perspective. SAGE Open Medicine 2019, 7: 2050312119854579. PMID: 31210934, PMCID: PMC6545680, DOI: 10.1177/2050312119854579.Peer-Reviewed Original ResearchTibial balloon angioplastyCritical limb ischaemiaBalloon angioplastyAntiplatelet therapyLimb ischaemiaCritical limb ischaemia patientsNumber of patientsMultiple comorbiditiesPreclinical dataAngioplasty techniquesTherapeutic approachesHigh riskPost interventionAngioplastyClinical perspectiveTherapyIschaemiaPatientsShort durationComorbiditiesTrialsImportant role
2015
Comorbidities Frequency in Takotsubo Syndrome: An International Collaborative Systematic Review Including 1109 Patients
Pelliccia F, Parodi G, Greco C, Antoniucci D, Brenner R, Bossone E, Cacciotti L, Capucci A, Citro R, Delmas C, Guerra F, Ionescu CN, Lairez O, Larrauri-Reyes M, Lee PH, Mansencal N, Marazzi G, Mihos CG, Morel O, Nef HM, Gil I, Passaseo I, Pineda AM, Rosano G, Santana O, Schneck F, Song BG, Song JK, Teh AW, Ungprasert P, Valbusa A, Wahl A, Yoshida T, Gaudio C, Kaski JC. Comorbidities Frequency in Takotsubo Syndrome: An International Collaborative Systematic Review Including 1109 Patients. The American Journal Of Medicine 2015, 128: 654.e11-654.e19. PMID: 25660245, DOI: 10.1016/j.amjmed.2015.01.016.Peer-Reviewed Original ResearchConceptsTakotsubo syndromeCollaborative systematic reviewSystematic reviewRisk factorsInternational collaborative systematic reviewCardiovascular risk factorsChronic kidney diseaseComorbidities of patientsClinical characteristicsCommon comorbiditiesPulmonary diseaseKidney diseaseCumulative prevalenceThyroid diseaseComorbidity frequencyNeurologic diseaseRelevant prevalenceIndependent reviewersNineteen studiesComorbiditiesPatientsSyndromeEmotional stressorsDiseaseRelevant studies
2014
Prospective chest pain evaluation in the emergency department with use of high-sensitivity C-reactive protein (PROCEED-CRP study).
Ionescu CN, Chrissoheris MP, Slim HB, Slade M, Oen-Hsiao J, Donohue TJ, Bekui A, Ghantous AE. Prospective chest pain evaluation in the emergency department with use of high-sensitivity C-reactive protein (PROCEED-CRP study). Connecticut Medicine 2014, 78: 133-8. PMID: 24772828.Peer-Reviewed Original ResearchConceptsHigh-sensitivity C-reactive proteinC-reactive proteinAcute myocardial infarctionEmergency departmentCause rehospitalizationChest painMyocardial infarctionChest pain evaluationCoronary revascularizationHs-CRPConsecutive patientsFinal cohortPain evaluationMyocardial ischemiaClinical valuePatientsRehospitalizationPainInfarctionDepartmentDaysRevascularizationIschemiaCohortCRP
2011
Left ventricular noncompaction and aneurysm revealed by left ventriculography
Ionescu CN, Turcot D. Left ventricular noncompaction and aneurysm revealed by left ventriculography. Catheterization And Cardiovascular Interventions 2011, 80: 109-111. PMID: 21954168, DOI: 10.1002/ccd.23322.Peer-Reviewed Original ResearchMeSH KeywordsAnticoagulantsCardiac CatheterizationDefibrillators, ImplantableEchocardiographyElectric CountershockElectrocardiography, AmbulatoryHeart AneurysmHeart VentriclesHumansIsolated Noncompaction of the Ventricular MyocardiumMaleMiddle AgedPredictive Value of TestsRadiographyStroke VolumeTachycardia, VentricularVentricular Function, LeftWarfarinConceptsLeft ventriculographyCardiac catheterizationNoninvasive testsVentricular noncompactionNonobstructive coronary artery diseaseCoronary artery diseaseLeft ventricular aneurysmLeft ventricular noncompactionArtery diseaseEjection fractionVentricular aneurysmRare caseCatheterizationNoncompactionVentriculographyAneurysmsPatientsDisease
2010
Treatment and outcomes of nonagenarians with ST-elevation myocardial infarction.
Ionescu CN, Amuchastegui M, Ionescu S, Marcu CB, Donohue T. Treatment and outcomes of nonagenarians with ST-elevation myocardial infarction. Journal Of Invasive Cardiology 2010, 22: 474-8. PMID: 20944186.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionPercutaneous coronary interventionReperfusion therapyMyocardial infarctionOutcome of nonagenariansMedical therapy groupAcute coronary syndromeMajority of patientsKaplan-Meier analysisProcedure-associated complicationsTreatment of patientsYears of ageHospital mortalityPCI groupCoronary syndromeCoronary interventionHospital dischargeOlder patientsSurvival benefitBetter prognosisCurrent guidelinesTherapy groupLower incidenceRetrospective analysisPatientsLong-term Outcome of Tako-tsubo Cardiomyopathy
Ionescu CN, Aguilar-Lopez CA, Sakr AE, Ghantous AE, Donohue TJ. Long-term Outcome of Tako-tsubo Cardiomyopathy. Heart Lung And Circulation 2010, 19: 601-605. PMID: 20655278, DOI: 10.1016/j.hlc.2010.06.667.Peer-Reviewed Original ResearchConceptsTako-tsubo cardiomyopathyLong-term outcomesMyocardial Infarction (TIMI) myocardial perfusion gradeCombined end pointMyocardial perfusion gradeLeft heart catheterisationSudden cardiac deathCardiac reasonsCardiogenic shockHeart catheterisationCardiac deathPerfusion gradeMean agePrognostic implicationsExcellent outcomesRetrospective analysisCaucasian femalePatientsEnd pointOutcomesFive-year periodCardiomyopathyTMPGStressor eventsCurrent data