2000
Immunocytochemical Characterization of Murine Hex, a Homeobox-Containing Protein
Ghosh B, Ganea G, Denson L, Iannucci R, Jacobs H, Bogue C. Immunocytochemical Characterization of Murine Hex, a Homeobox-Containing Protein. Pediatric Research 2000, 48: 634-638. PMID: 11044484, DOI: 10.1203/00006450-200011000-00014.Peer-Reviewed Original ResearchConceptsMouse embryosGlutathione S-transferase fusion proteinS-transferase fusion proteinDivergent homeobox genesWhole mouse embryosTerminal amino acidsHepatic specificationHex proteinHomeobox genesMouse developmentDefinitive endodermBlood islandsNuclear localizationEndodermal cellsFusion proteinHex expressionProtein presentCultured cellsAmino acidsWhole mountsConfocal microscopyHepatic diverticulumProteinEmbryosWestern blotHex expression suggests a role in the development and function of organs derived from foregut endoderm
Bogue C, Ganea G, Sturm E, Ianucci R, Jacobs H. Hex expression suggests a role in the development and function of organs derived from foregut endoderm. Developmental Dynamics 2000, 219: 84-89. PMID: 10974674, DOI: 10.1002/1097-0177(2000)9999:9999<::aid-dvdy1028>3.0.co;2-5.Peer-Reviewed Original ResearchConceptsExtrahepatic biliary ductsMature animalsMaintenance of functionThymus originatesAdult thyroidDorsal pancreatic budLung expressionBile ductBiliary ductsThymic expressionFunction of organsDuct epitheliumLungThyroidE16.5 embryosLiverEpithelial cellsThymusSeptum transversumMesenchymal cellsPotential roleHex expressionDetectable levelsPharyngeal pouchesOrgansDivergent homeobox gene Hex regulates promoter of the Na+-dependent bile acid cotransporter
Denson L, Karpen S, Bogue C, Jacobs H. Divergent homeobox gene Hex regulates promoter of the Na+-dependent bile acid cotransporter. AJP Gastrointestinal And Liver Physiology 2000, 279: g347-g355. PMID: 10915644, DOI: 10.1152/ajpgi.2000.279.2.g347.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCarrier ProteinsCOS CellsGene Expression RegulationGenetic Complementation TestHepatoblastomaHomeodomain ProteinsHumansLiverLiver NeoplasmsMembrane Transport ProteinsMolecular Sequence DataMutagenesisOligonucleotide ProbesOrganic Anion Transporters, Sodium-DependentPromoter Regions, GeneticRatsRecombinant Fusion ProteinsSymportersTranscription FactorsTranscription, GeneticTumor Cells, CulturedConceptsHomeobox gene HexDivergent homeobox gene HexNtcp promoterHex proteinHep G2 cellsElectrophoretic mobility shift assaysMobility shift assaysHeterologous promoter constructsDominant-negative formG2 cellsSpecific nuclear proteinLuciferase reporter constructsNuclear proteinsGene promoterShift assaysCOS cellsBasal luciferase activityReporter constructsPromoter regionBile acid cotransporterPromoter constructsResponse elementNegative formPromoterAcid cotransporterHNF3β and GATA-4 transactivate the liver-enriched homeobox gene, Hex
Denson L, McClure M, Bogue C, Karpen S, Jacobs H. HNF3β and GATA-4 transactivate the liver-enriched homeobox gene, Hex. Gene 2000, 246: 311-320. PMID: 10767553, DOI: 10.1016/s0378-1119(00)00082-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCOS CellsDNADNA-Binding ProteinsGATA4 Transcription FactorGenes, HomeoboxHepatocyte Nuclear Factor 3-betaHomeodomain ProteinsHumansLiverLuciferasesMaleMiceMolecular Sequence DataNuclear ProteinsPlasmidsPromoter Regions, GeneticProtein BindingRatsRats, Sprague-DawleyRecombinant Fusion ProteinsSequence Analysis, DNASp1 Transcription FactorSp3 Transcription FactorTranscription FactorsTranscriptional ActivationTransfectionTumor Cells, Cultured
1999
Genomic structure, cDNA mapping, and chromosomal localization of the mouse homeobox gene, Hex
Ghosh B, Jacobs H, Wiedemann L, Brown A, Bedford F, Nimmakayalu M, Ward D, Bogue C. Genomic structure, cDNA mapping, and chromosomal localization of the mouse homeobox gene, Hex. Mammalian Genome 1999, 10: 1023-1025. PMID: 10501975, DOI: 10.1007/s003359901152.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsBase SequenceChromosome MappingCloning, MolecularCrosses, GeneticGenes, HomeoboxGenetic LinkageGenetic MarkersHomeodomain ProteinsIn Situ Hybridization, FluorescenceLiverMiceMice, Inbred StrainsMolecular Sequence DataRestriction MappingSequence AnalysisTranscription Factors
1998
Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats
Jacobs H, Bogue C, Pinter E, Wilson C, Warshaw J, Gross I. Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats. Pediatric Research 1998, 44: 99-104. PMID: 9667378, DOI: 10.1203/00006450-199807000-00016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsButyratesButyric AcidDiabetes Mellitus, ExperimentalEmbryonic and Fetal DevelopmentFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxGestational AgeHistone Deacetylase InhibitorsLungOrgan Culture TechniquesPregnancyPregnancy in DiabeticsRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticConceptsLung developmentLung explantsSurfactant apoproteinExperimental animalsLung mRNA levelsElevated levelsEffect of diabetesFetal rat lung explantsLungs of fetusesRat lung explantsEffect of butyrateAntenatal exposureMaternal diabetesMetabolic abnormalitiesStreptozotocin treatmentLower incidenceNormal ratsDiabetesDexamethasoneLevel of expressionRatsTreatment of explantsSodium butyrateMRNA levelsAlters expression
1995
Fatal enterovirus type 71 infection
LANDRY M, FONSECA S, COHEN S, BOGUE C. Fatal enterovirus type 71 infection. The Pediatric Infectious Disease Journal 1995, 14: 1095-1100. PMID: 8745025, DOI: 10.1097/00006454-199512000-00013.Peer-Reviewed Original Research