2014
“Tissue is the Issue”: Circulating Tumor Cells in Pancreatic Cancer
George T, Ogunwobi O, Sheng W, Fan Z, Liu C. “Tissue is the Issue”: Circulating Tumor Cells in Pancreatic Cancer. Journal Of Gastrointestinal Cancer 2014, 45: 222-225. PMID: 25012516, PMCID: PMC4440834, DOI: 10.1007/s12029-014-9638-3.Peer-Reviewed Original ResearchCapture, release and culture of circulating tumor cells from pancreatic cancer patients using an enhanced mixing chip
Sheng W, Ogunwobi O, Chen T, Zhang J, George T, Liu C, Fan Z. Capture, release and culture of circulating tumor cells from pancreatic cancer patients using an enhanced mixing chip. Lab On A Chip 2014, 14: 89-98. PMID: 24220648, PMCID: PMC3918168, DOI: 10.1039/c3lc51017d.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, ImmobilizedAntigens, NeoplasmAntineoplastic AgentsCell Adhesion MoleculesCell Line, TumorCell SeparationCell SurvivalEpithelial Cell Adhesion MoleculeHumansLeukocyte Common AntigensMaleMicrofluidic Analytical TechniquesNeoplastic Cells, CirculatingPancreatic NeoplasmsTomography, X-Ray ComputedConceptsHigh-performance microchipsMicromixer structurePresented technologyReal-time monitoringChannel geometryFlow rateTransverse flowCapture efficiencyChipDevicesCell capturePersonalized therapeutic treatmentsTumor cell captureAntibody-coated surfaceGreat promiseSpiked tumor cellsIsolation of CTCsWide rangeCancer patients' blood
2013
Epigenetic Upregulation of HGF and c-Met Drives Metastasis in Hepatocellular Carcinoma
Ogunwobi O, Puszyk W, Dong H, Liu C. Epigenetic Upregulation of HGF and c-Met Drives Metastasis in Hepatocellular Carcinoma. PLOS ONE 2013, 8: e63765. PMID: 23723997, PMCID: PMC3665785, DOI: 10.1371/journal.pone.0063765.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCarcinogenesisCarcinoma, HepatocellularCell Line, TumorDNA MethylationEpigenesis, GeneticEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHepatocyte Growth FactorHumansLiver NeoplasmsMesodermMiceMice, Inbred BALB CModels, BiologicalMolecular Sequence DataNeoplastic Cells, CirculatingPromoter Regions, GeneticProto-Oncogene Proteins c-metUp-RegulationConceptsEpithelial-mesenchymal transitionHepatocyte growth factorExpression of HGFHepatocellular carcinomaC-MetHematogenous disseminationTumor cellsRole of HGFOrthotopic syngeneic modelsMetastatic hepatocellular carcinomaMouse HCC modelC-Met expressionUpregulation of HGFPrimary tumor cellsPromoter demethylationNovel non-invasive approachPotential clinical applicationsPeripheral bloodSyngeneic modelHCC managementDrives metastasisEpigenetic upregulationHCC modelTumor progressionMetastatic potential