2019
T cell–derived interferon-γ programs stem cell death in immune-mediated intestinal damage
Takashima S, Martin M, Jansen S, Fu Y, Bos J, Chandra D, O'Connor M, Mertelsmann A, Vinci P, Kuttiyara J, Devlin S, Middendorp S, Calafiore M, Egorova A, Kleppe M, Lo Y, Shroyer N, Cheng E, Levine R, Liu C, Kolesnick R, Lindemans C, Hanash A. T cell–derived interferon-γ programs stem cell death in immune-mediated intestinal damage. Science Immunology 2019, 4 PMID: 31811055, PMCID: PMC7239329, DOI: 10.1126/sciimmunol.aay8556.Peer-Reviewed Original ResearchConceptsBone marrow transplantationIntestinal stem cellsDonor T cellsStem cell compartmentT cellsStem cell deathEpithelial culturesAllogeneic bone marrow transplantationDysregulated T cell activationT cell-mediated pathologyInhibition of JAK signalingStem cellsImmune-mediated damageActivated T cellsT cell activationCell compartmentCell deathTissue stem cellsPaneth cell nicheIFNg productionMarrow transplantationIntestinal immunopathologyInterferon-gHealthy miceStem cell colonies
2009
Loss of Carbamoyl Phosphate Synthetase I in Small-Intestinal Adenocarcinoma
Cardona D, Zhang X, Liu C. Loss of Carbamoyl Phosphate Synthetase I in Small-Intestinal Adenocarcinoma. American Journal Of Clinical Pathology 2009, 132: 877-882. PMID: 19926579, DOI: 10.1309/ajcp74xgrfwtflju.Peer-Reviewed Original ResearchConceptsCases of duodenitisWestern blot analysisHep Par 1 antibodyHep Par 1 expressionHep Par 1Low-grade dysplasiaPAR-1 expressionBlot analysisExpression of CPS1CPS1 expressionIntestinal adenocarcinomaImmunohistochemical findingsInvasive adenocarcinomaInvasive tumorsMalignant tumorsAntigen expressionNormal mucosaControl groupAdenocarcinomaPAR-1AdenomasSmall intestine enterocytes
2005
CCR2 is required for CD8-induced graft-versus-host disease
Terwey T, Kim T, Kochman A, Hubbard V, Lu S, Zakrzewski J, Ramirez-Montagut T, Eng J, Muriglan S, Heller G, Murphy G, Liu C, Budak-Alpdogan T, Alpdogan O, van den Brink M. CCR2 is required for CD8-induced graft-versus-host disease. Blood 2005, 106: 3322-3330. PMID: 16037386, PMCID: PMC1895329, DOI: 10.1182/blood-2005-05-1860.Peer-Reviewed Original ResearchConceptsCC chemokine receptor 2Hematopoietic stem cell transplantationDevelopment of GVHDT cellsT cell migrationHost diseaseAllogeneic hematopoietic stem cell transplantationDonor-derived T cellsControl of CD8Donor-derived CD8GVHD target organsMurine bone marrow transplantation modelBone marrow transplantation modelStem cell transplantationChemokine receptor 2IFN-gamma productionWild-type CD8Alloreactive proliferationDonor CD8GVHD morbidityGVT activityTumor effectMajor complicationsCCR2 signalingCell transplantation
2003
LPAM (α4β7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease
Petrovic A, Alpdogan O, Willis L, Eng J, Greenberg A, Kappel B, Liu C, Murphy G, Heller G, van den Brink M. LPAM (α4β7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease. Blood 2003, 103: 1542-1547. PMID: 14563643, DOI: 10.1182/blood-2003-03-0957.Peer-Reviewed Original ResearchConceptsDonor T cellsT cellsMurine allogeneic bone marrow transplantation modelAllogeneic bone marrow transplantation modelAlloreactive donor T cellsGut-associated lymphoid tissueAdhesion moleculesMucosal addressin cell adhesion moleculeGVHD target organsMesenteric lymph nodesAlloreactive T cellsBone marrow transplantation modelMucosal lymphoid organsHigh endothelial venulesGVHD morbidityGVT activityIntestinal graftIntestinal GVHDLess graftLess GVHDHost diseaseLymph nodesDisease morbidityLymphoid organsLymphoid tissue