2001
Neonatal auditory activation detected by functional magnetic resonance imaging
Anderson A, Marois R, Colson E, Peterson B, Duncan C, Ehrenkranz R, Schneider K, Gore J, Ment L. Neonatal auditory activation detected by functional magnetic resonance imaging. Magnetic Resonance Imaging 2001, 19: 1-5. PMID: 11295339, DOI: 10.1016/s0730-725x(00)00231-9.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingAuditory stimulationSuperior temporal regionsSuperior temporal gyrusAuditory cortical activationMagnetic resonance imagingFunctional brain imagingBlood oxygen level-dependent (BOLD) signalLevel-dependent signalBOLD signal responseAuditory stimuliBrain activationFMRI studyAuditory activationTemporal gyrusResonance imagingBOLD responseCortical activationHuman infantsTemporal regionsAdult control subjectsBrain imagingHealthy neonatesPure tonesControl subjects
1989
Beagle puppy model of perinatal asphyxia: Blockade of excitatory neurotransmitters
Ment L, Stewart W, Petroff O, Duncan C, Montoya D. Beagle puppy model of perinatal asphyxia: Blockade of excitatory neurotransmitters. Pediatric Neurology 1989, 5: 281-286. PMID: 2553028, DOI: 10.1016/0887-8994(89)90018-0.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonist MK801Cerebral blood flowBlood flowPerinatal asphyxiaCerebral high-energy phosphatesN-methyl-D-aspartate receptorsSaline 15 minBeagle puppy modelModel of ischemiaNewborn beagle puppiesHigh-energy phosphatesNeuropathologic damageAsphyxial insultPuppy modelNeuronal changesCerebral lactateExcitatory neurotransmitterBrainstem structuresPhosphocreatine levelsDrug treatmentMetabolic insultsBeagle puppiesMK801InsultPuppiesThromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia.
Ment L, Stewart W, Petroff O, Duncan C. Thromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia. Stroke 1989, 20: 809-814. PMID: 2728050, DOI: 10.1161/01.str.20.6.809.Peer-Reviewed Original ResearchConceptsCerebral blood flowThromboxane synthesis inhibitorBlood flowPerinatal asphyxiaSynthesis inhibitorCGS 13080Intraventricular hemorrhageLactate levelsCerebral regionsHigh incidenceMetabolic alterationsWhite matterLactate concentrationAsphyxiaBrain extractsInsultPhosphocreatine concentrationPupsSalineInhibitorsHemorrhageProstaglandinsMedulla
1988
Intraventricular hemorrhage of the preterm neonate: prevention studies.
Ment L, Ehrenkranz R, Duncan C. Intraventricular hemorrhage of the preterm neonate: prevention studies. Seminars In Perinatology 1988, 12: 359-72. PMID: 3065945.Peer-Reviewed Original ResearchBeagle puppy model of perinatal asphyxia: Alterations in cerebral blood flow and metabolism
Ment L, Stewart W, Gore J, Duncan C. Beagle puppy model of perinatal asphyxia: Alterations in cerebral blood flow and metabolism. Pediatric Neurology 1988, 4: 98-104. PMID: 3149477, DOI: 10.1016/0887-8994(88)90048-3.Peer-Reviewed Original ResearchConceptsCerebral blood flowBeagle puppy modelPerinatal asphyxiaPuppy modelBlood flowControl of CBFUncoupling of CBFATP/Pi ratioBaseline 1 hourRadioactive microsphere determinationsPCr/PiWhite matter regionsDays of ageAsphyxial episodesAsphyxial insultNeurodevelopmental handicapArterial pressureClinical sequelaeElectrocerebral silenceMicrosphere determinationBrainstem structuresCBF dataBaseline valuesPathologic conditionsAsphyxia
1987
Beagle pup model of brain injury: regional cerebral blood flow and cerebral prostaglandins.
Ment L, Stewart W, Duncan C, Pitt B, Cole J. Beagle pup model of brain injury: regional cerebral blood flow and cerebral prostaglandins. Journal Of Neurosurgery 1987, 67: 278-83. PMID: 3598687, DOI: 10.3171/jns.1987.67.2.0278.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAsphyxia NeonatorumBrainBrain InjuriesCerebrovascular CirculationDog DiseasesDogsProstaglandinsConceptsRegional cerebral blood flowCerebral blood flowAsphyxial insultBrain injuryBlood flowSevere asphyxial insultPeriventricular white matterSevere brain injuryRole of prostaglandinsEffects of asphyxiaNewborn beagle pupsCerebral prostaglandinsVentilatory supportNeuropathological changesPGE2 levelsCommon causeBeagle pupsWhite matterAutoradiographic determinationInsultPupsAsphyxiaYoung childrenSeparate groupsSignificant increase
1986
Beagle puppy model of perinatal cerebral insults. Cerebral blood flow changes and intraventricular hemorrhage evoked by hypoxemia.
Ment L, Stewart W, Duncan C, Pitt B. Beagle puppy model of perinatal cerebral insults. Cerebral blood flow changes and intraventricular hemorrhage evoked by hypoxemia. Journal Of Neurosurgery 1986, 65: 847-50. PMID: 3772483, DOI: 10.3171/jns.1986.65.6.0847.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBrain DiseasesCerebral HemorrhageCerebral InfarctionCerebral VentriclesCerebrovascular CirculationDogsFemaleFetal DiseasesHypoxiaModels, BiologicalPregnancyConceptsCerebral blood flowWhite matterIntraventricular hemorrhageRegional cerebral blood flowCerebral blood flow changesNeonatal cerebral infarctionPerinatal cerebral insultsParieto-occipital white matterEffects of hypoxemiaBeagle puppy modelNewborn beagle pupsBlood flow changesTemporal white matterParietal white matterCentral gray regionNeuropathological injuryCerebral infarctionPerinatal asphyxiaCerebral insultNeuropathological changesPuppy modelCommon causeGerminal matrixBeagle pupsBlood flowBeagle puppy model of perinatal cerebral infarction. Regional cerebral prostaglandin changes during acute hypoxemia.
Ment L, Stewart W, Duncan C, Pitt B, Cole J. Beagle puppy model of perinatal cerebral infarction. Regional cerebral prostaglandin changes during acute hypoxemia. Journal Of Neurosurgery 1986, 65: 851-5. PMID: 3772484, DOI: 10.3171/jns.1986.65.6.0851.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsAnimals, NewbornCerebral InfarctionCerebrovascular CirculationDogsFemaleFetal DiseasesHypoxiaModels, BiologicalPregnancyProstaglandinsConceptsCerebral blood flowPerinatal cerebral infarctionPeriventricular white matterCerebral infarctionHypoxemic insultWhite matterStable metaboliteGray matterLocal cerebral blood flowArterial blood pressureEffects of hypoxemiaBeagle puppy modelNewborn beagle pupsSignificant differencesAcute hypoxemiaProstaglandin changesNeuropathological alterationsBlood pressureIndwelling catheterNeuropathological changesIntensive carePuppy modelUncommon findingProstaglandin levelsCommon cause
1985
Beagle puppy model of perinatal cerebral infarction. Acute changes in regional cerebral prostaglandins during hemorrhagic hypotension.
Ment L, Stewart W, Duncan C, Cole J, Pitt B. Beagle puppy model of perinatal cerebral infarction. Acute changes in regional cerebral prostaglandins during hemorrhagic hypotension. Journal Of Neurosurgery 1985, 63: 899-904. PMID: 4056903, DOI: 10.3171/jns.1985.63.6.0899.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCerebral HemorrhageCerebral InfarctionCerebrovascular CirculationDisease Models, AnimalDogsHypotensionProstaglandinsProstaglandins EThromboxane A2Thromboxane B2ConceptsPerinatal cerebral infarctionPeriventricular white matterNewborn beagle pupsHemorrhagic hypotensionWhite matterCerebral infarctionNeuropathological changesThromboxane B2Beagle pupsMean arterial blood pressureSlow venous hemorrhagePeriventricular white matter regionsArterial blood pressureProstaglandin E2 levelsEffects of hypotensionCerebral blood flowProstaglandin determinationsBeagle puppy modelStable breakdown productWhite matter regionsCerebral prostaglandinsBlood pressureIntensive carePuppy modelPGF1 alphaBeagle puppy model of perinatal cerebral infarction. Acute changes in cerebral blood flow and metabolism during hemorrhagic hypotension.
Ment L, Stewart W, Duncan C, Pitt B, Rescigno A, Cole J. Beagle puppy model of perinatal cerebral infarction. Acute changes in cerebral blood flow and metabolism during hemorrhagic hypotension. Journal Of Neurosurgery 1985, 63: 441-7. PMID: 3839525, DOI: 10.3171/jns.1985.63.3.0441.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAsphyxia NeonatorumBrainCerebral HemorrhageCerebral InfarctionCerebrovascular CirculationDogsGlucoseHumansHypotensionInfant, NewbornConceptsLocal cerebral glucose utilizationCerebral blood flowRegional cerebral blood flowHypotensive insultCerebral infarctionHemorrhagic hypotensionBlood flowUncoupling of CBFMean arterial blood pressureNeonatal cerebral infarctionParieto-occipital white matterPerinatal cerebral infarctionSerum prostaglandin levelsSlow venous hemorrhagePeriventricular white matter regionsAutoradiographic determinationArterial blood pressureCerebral glucose utilizationProstaglandin E2 levelsEffects of hypotensionBeagle puppy modelNewborn beagle pupsGray matter structuresStable breakdown productWhite matter regionsBeagle puppy model of intraventricular hemorrhage. Effect of superoxide dismutase on cerebral blood flow and prostaglandins.
Ment L, Stewart W, Duncan C. Beagle puppy model of intraventricular hemorrhage. Effect of superoxide dismutase on cerebral blood flow and prostaglandins. Journal Of Neurosurgery 1985, 62: 563-9. PMID: 3973726, DOI: 10.3171/jns.1985.62.4.0563.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCerebral HemorrhageCerebral VentriclesCerebrovascular CirculationDogsModels, BiologicalProstaglandinsSuperoxide DismutaseConceptsCerebral blood flowIntraventricular hemorrhageProstaglandin levelsBlood flowSuperoxide dismutaseCarbon-14-iodoantipyrine autoradiographyIncidence of IVHSystemic blood pressure changesBaseline cerebral blood flowLocal cerebral blood flowDetermination of CBFBlood pressure changesSaline-pretreated animalsBeagle puppy modelNewborn beagle pupsGerminal matrix tissueHypotensive insultFree radical scavengerPreterm neonatesIodoantipyrine autoradiographyPuppy modelBeagle pupsCapillary morphologyInsultHemorrhage
1984
Delayed Hemorrhagic Infarction: A Cause of Late Neonatal Germinal Matrix and Intraventricular Hemorrhage
Ment L, Ehrenkranz R, Duncan C, Lange R. Delayed Hemorrhagic Infarction: A Cause of Late Neonatal Germinal Matrix and Intraventricular Hemorrhage. JAMA Neurology 1984, 41: 1036-1039. PMID: 6477210, DOI: 10.1001/archneur.1984.04050210034010.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageCerebral InfarctionCerebral VentriclesCerebrovascular CirculationFemaleHumansInfant, NewbornInfant, Premature, DiseasesMaleConceptsCerebral blood flowLow cerebral blood flowLate intraventricular hemorrhageIntraventricular hemorrhageFirst postnatal dayMonths of ageSeries of insultsProfound hypotensionPorencephalic cystPostnatal eventsGerminal matrixPostnatal dayBlood flowHemorrhageNeonatesTomographic evidenceInfarcted tissueHypotensionTissueAsphyxiaEncephalomalaciaInfarctionInfantsCystsInsultIntraventricular hemorrhage in the preterm neonate: Timing and cerebral blood flow changes
Ment L, Duncan C, Ehrenkranz R, Lange R, Taylor K, Kleinman C, Scott D, Sivo J, Gettner P. Intraventricular hemorrhage in the preterm neonate: Timing and cerebral blood flow changes. The Journal Of Pediatrics 1984, 104: 419-425. PMID: 6707798, DOI: 10.1016/s0022-3476(84)81109-9.Peer-Reviewed Original ResearchConceptsGMH/IVHCerebral blood flowPostnatal hoursBlood flowEarly hemorrhagePreterm neonatesIntraventricular hemorrhageIVH groupUltrasound studyLow cerebral blood flowCerebral blood flow changesCerebral blood flow determinationsCranial ultrasound studiesHigh ventilator settingsCerebral blood flow valuesPatent ductus arteriosusBlood flow changesRisk factor analysisBlood flow determinationsBlood flow valuesTime of birthVigorous resuscitationNeonatal eventsDuctus arteriosusEchocardiographic study
1983
The ramp injection of radiotracers for blood flow measurement by emission tomography
Duncan C, Lambrecht R, Rescigno A, Shiue C, Bennett G, Ment L. The ramp injection of radiotracers for blood flow measurement by emission tomography. Physics In Medicine And Biology 1983, 28: 963-972. PMID: 6604926, DOI: 10.1088/0031-9155/28/8/008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntipyrineCatsCerebrovascular CirculationFluorineInjections, Intra-ArterialRadioisotopesTomography, Emission-ComputedBeagle puppy model of intraventricular hemorrhage. Effect of indomethacin on cerebral blood flow.
Ment L, Stewart W, Duncan C, Scott D, Lambrecht R. Beagle puppy model of intraventricular hemorrhage. Effect of indomethacin on cerebral blood flow. Journal Of Neurosurgery 1983, 58: 857-62. PMID: 6854378, DOI: 10.3171/jns.1983.58.6.0857.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PressureCerebral HemorrhageCerebrovascular CirculationDisease Models, AnimalDog DiseasesDogsIndomethacinConceptsCerebral blood flowIntraventricular hemorrhageNewborn beagle puppiesBeagle puppiesBlood flowDetermination of CBFBlood pressure responseNeonatal intraventricular hemorrhageEffect of indomethacinBeagle puppy modelNewborn beagle pupsPuppy modelBeagle pupsIndomethacinProstaglandin synthetaseInsultPupsFormer groupSignificant alterationsPressure responseHemorrhagePuppiesSalineGroupBeagle puppy model of intraventricular hemorrhage: randomized indomethacin prevention trial.
Ment L, Stewart W, Scott D, Duncan C. Beagle puppy model of intraventricular hemorrhage: randomized indomethacin prevention trial. Neurology 1983, 33: 179-84. PMID: 6681659, DOI: 10.1212/wnl.33.2.179.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBlood PressureCerebral HemorrhageCerebral VentriclesCerebrovascular CirculationDisease Models, AnimalDogsIndomethacinConceptsIntraventricular hemorrhageNewborn beagle puppiesBeagle puppiesBlood pressure responseNeonatal intraventricular hemorrhageBeagle puppy modelPrevention trialsHemorrhagic hypotensionPuppy modelSaline vehicleControl animalsHemorrhageProstaglandin synthetaseExperimental modelIndomethacinSignificant alterationsPressure responsePuppiesPostpartum Perfusion of the Preterm Brain: Relationship to Neurodevelopmental Outcome
Ment L, Scott D, Lange R, Ehrenkranz R, Duncan C, Warshaw J. Postpartum Perfusion of the Preterm Brain: Relationship to Neurodevelopmental Outcome. Child's Brain 1983, 10: 266-272. PMID: 6884128, DOI: 10.1159/000120122.Peer-Reviewed Original ResearchConceptsCerebral blood flow measurementsCBF valuesHigher CBF valuesComputerized tomography scanDays of lifeBlood flow measurementsIntraventricular hemorrhageNeurodevelopmental outcomesPreterm brainPreterm infantsFavorable outcomeTomography scanMental indexDevelopmental assessmentLeft hemisphereOutcomesHemorrhageInfantsPerfusion
1982
Local cerebral glucose utilization in the beagle puppy model of intraventricular hemorrhage.
Ment L, Stewart W, Duncan C. Local cerebral glucose utilization in the beagle puppy model of intraventricular hemorrhage. Journal Of Neurosurgery 1982, 57: 384-9. PMID: 7097335, DOI: 10.3171/jns.1982.57.3.0384.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAutoradiographyBrainCarbon RadioisotopesCerebral HemorrhageCerebral VentriclesCerebrovascular CirculationDeoxyglucoseDisease Models, AnimalDogsGlucoseConceptsLocal cerebral glucose utilizationCerebral glucose utilizationBeagle puppy modelIntraventricular hemorrhagePuppy modelGlucose utilizationCerebral blood flowAdult animal studiesWhite matter differentiationControl pupsBlood flowAnimal studiesNeuropathological conditionsBrain regionsHemorrhageMatter differentiationUptakePupsBeagle puppy model of intraventricular hemorrhage.
Ment L, Stewart W, Duncan C, Lambrecht R. Beagle puppy model of intraventricular hemorrhage. Journal Of Neurosurgery 1982, 57: 219-23. PMID: 7086514, DOI: 10.3171/jns.1982.57.2.0219.Peer-Reviewed Original Research
1981
Alterations in cerebral blood flow in preterm infants with intraventricular hemorrhage.
Ment L, Ehrenkranz R, Lange R, Rothstein P, Duncan C. Alterations in cerebral blood flow in preterm infants with intraventricular hemorrhage. Pediatrics 1981, 68: 763-9. PMID: 7322711, DOI: 10.1542/peds.68.6.763.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageCerebral VentriclesCerebrovascular CirculationHumansInfantInfant, NewbornInfant, Premature, DiseasesTomography, X-Ray ComputedXenon RadioisotopesConceptsWeeks postconceptual ageGerminal matrix hemorrhageIntraventricular hemorrhageIVH groupPreterm infantsPostconceptual ageCerebral blood flow determinationsCerebral blood flowComputed tomography scanGroups of infantsBlood flow determinationsNonhemorrhage patientsIVH patientsAutopsy findingsTomography scanCT scanBlood flowHemorrhageHemispheric ratioInfantsMean differencePatientsLower mean valuesInterhemispheric ratioAge