1989
Beagle puppy model of perinatal asphyxia: Blockade of excitatory neurotransmitters
Ment L, Stewart W, Petroff O, Duncan C, Montoya D. Beagle puppy model of perinatal asphyxia: Blockade of excitatory neurotransmitters. Pediatric Neurology 1989, 5: 281-286. PMID: 2553028, DOI: 10.1016/0887-8994(89)90018-0.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonist MK801Cerebral blood flowBlood flowPerinatal asphyxiaCerebral high-energy phosphatesN-methyl-D-aspartate receptorsSaline 15 minBeagle puppy modelModel of ischemiaNewborn beagle puppiesHigh-energy phosphatesNeuropathologic damageAsphyxial insultPuppy modelNeuronal changesCerebral lactateExcitatory neurotransmitterBrainstem structuresPhosphocreatine levelsDrug treatmentMetabolic insultsBeagle puppiesMK801InsultPuppiesThromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia.
Ment L, Stewart W, Petroff O, Duncan C. Thromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia. Stroke 1989, 20: 809-814. PMID: 2728050, DOI: 10.1161/01.str.20.6.809.Peer-Reviewed Original ResearchConceptsCerebral blood flowThromboxane synthesis inhibitorBlood flowPerinatal asphyxiaSynthesis inhibitorCGS 13080Intraventricular hemorrhageLactate levelsCerebral regionsHigh incidenceMetabolic alterationsWhite matterLactate concentrationAsphyxiaBrain extractsInsultPhosphocreatine concentrationPupsSalineInhibitorsHemorrhageProstaglandinsMedulla
1988
Beagle puppy model of perinatal asphyxia: Alterations in cerebral blood flow and metabolism
Ment L, Stewart W, Gore J, Duncan C. Beagle puppy model of perinatal asphyxia: Alterations in cerebral blood flow and metabolism. Pediatric Neurology 1988, 4: 98-104. PMID: 3149477, DOI: 10.1016/0887-8994(88)90048-3.Peer-Reviewed Original ResearchConceptsCerebral blood flowBeagle puppy modelPerinatal asphyxiaPuppy modelBlood flowControl of CBFUncoupling of CBFATP/Pi ratioBaseline 1 hourRadioactive microsphere determinationsPCr/PiWhite matter regionsDays of ageAsphyxial episodesAsphyxial insultNeurodevelopmental handicapArterial pressureClinical sequelaeElectrocerebral silenceMicrosphere determinationBrainstem structuresCBF dataBaseline valuesPathologic conditionsAsphyxia
1983
Beagle puppy model of intraventricular hemorrhage. Effect of indomethacin on cerebral blood flow.
Ment L, Stewart W, Duncan C, Scott D, Lambrecht R. Beagle puppy model of intraventricular hemorrhage. Effect of indomethacin on cerebral blood flow. Journal Of Neurosurgery 1983, 58: 857-62. PMID: 6854378, DOI: 10.3171/jns.1983.58.6.0857.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PressureCerebral HemorrhageCerebrovascular CirculationDisease Models, AnimalDog DiseasesDogsIndomethacinConceptsCerebral blood flowIntraventricular hemorrhageNewborn beagle puppiesBeagle puppiesBlood flowDetermination of CBFBlood pressure responseNeonatal intraventricular hemorrhageEffect of indomethacinBeagle puppy modelNewborn beagle pupsPuppy modelBeagle pupsIndomethacinProstaglandin synthetaseInsultPupsFormer groupSignificant alterationsPressure responseHemorrhagePuppiesSalineGroupBeagle puppy model of intraventricular hemorrhage: randomized indomethacin prevention trial.
Ment L, Stewart W, Scott D, Duncan C. Beagle puppy model of intraventricular hemorrhage: randomized indomethacin prevention trial. Neurology 1983, 33: 179-84. PMID: 6681659, DOI: 10.1212/wnl.33.2.179.Peer-Reviewed Original ResearchConceptsIntraventricular hemorrhageNewborn beagle puppiesBeagle puppiesBlood pressure responseNeonatal intraventricular hemorrhageBeagle puppy modelPrevention trialsHemorrhagic hypotensionPuppy modelSaline vehicleControl animalsHemorrhageProstaglandin synthetaseExperimental modelIndomethacinSignificant alterationsPressure responsePuppies