1989
Beagle puppy model of perinatal asphyxia: Blockade of excitatory neurotransmitters
Ment L, Stewart W, Petroff O, Duncan C, Montoya D. Beagle puppy model of perinatal asphyxia: Blockade of excitatory neurotransmitters. Pediatric Neurology 1989, 5: 281-286. PMID: 2553028, DOI: 10.1016/0887-8994(89)90018-0.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonist MK801Cerebral blood flowBlood flowPerinatal asphyxiaCerebral high-energy phosphatesN-methyl-D-aspartate receptorsSaline 15 minBeagle puppy modelModel of ischemiaNewborn beagle puppiesHigh-energy phosphatesNeuropathologic damageAsphyxial insultPuppy modelNeuronal changesCerebral lactateExcitatory neurotransmitterBrainstem structuresPhosphocreatine levelsDrug treatmentMetabolic insultsBeagle puppiesMK801InsultPuppiesThromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia.
Ment L, Stewart W, Petroff O, Duncan C. Thromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia. Stroke 1989, 20: 809-814. PMID: 2728050, DOI: 10.1161/01.str.20.6.809.Peer-Reviewed Original ResearchConceptsCerebral blood flowThromboxane synthesis inhibitorBlood flowPerinatal asphyxiaSynthesis inhibitorCGS 13080Intraventricular hemorrhageLactate levelsCerebral regionsHigh incidenceMetabolic alterationsWhite matterLactate concentrationAsphyxiaBrain extractsInsultPhosphocreatine concentrationPupsSalineInhibitorsHemorrhageProstaglandinsMedulla
1988
Beagle puppy model of perinatal asphyxia: Alterations in cerebral blood flow and metabolism
Ment L, Stewart W, Gore J, Duncan C. Beagle puppy model of perinatal asphyxia: Alterations in cerebral blood flow and metabolism. Pediatric Neurology 1988, 4: 98-104. PMID: 3149477, DOI: 10.1016/0887-8994(88)90048-3.Peer-Reviewed Original ResearchConceptsCerebral blood flowBeagle puppy modelPerinatal asphyxiaPuppy modelBlood flowControl of CBFUncoupling of CBFATP/Pi ratioBaseline 1 hourRadioactive microsphere determinationsPCr/PiWhite matter regionsDays of ageAsphyxial episodesAsphyxial insultNeurodevelopmental handicapArterial pressureClinical sequelaeElectrocerebral silenceMicrosphere determinationBrainstem structuresCBF dataBaseline valuesPathologic conditionsAsphyxia
1987
Beagle pup model of brain injury: regional cerebral blood flow and cerebral prostaglandins.
Ment L, Stewart W, Duncan C, Pitt B, Cole J. Beagle pup model of brain injury: regional cerebral blood flow and cerebral prostaglandins. Journal Of Neurosurgery 1987, 67: 278-83. PMID: 3598687, DOI: 10.3171/jns.1987.67.2.0278.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAsphyxia NeonatorumBrainBrain InjuriesCerebrovascular CirculationDog DiseasesDogsProstaglandinsConceptsRegional cerebral blood flowCerebral blood flowAsphyxial insultBrain injuryBlood flowSevere asphyxial insultPeriventricular white matterSevere brain injuryRole of prostaglandinsEffects of asphyxiaNewborn beagle pupsCerebral prostaglandinsVentilatory supportNeuropathological changesPGE2 levelsCommon causeBeagle pupsWhite matterAutoradiographic determinationInsultPupsAsphyxiaYoung childrenSeparate groupsSignificant increase
1985
Beagle puppy model of perinatal cerebral infarction. Acute changes in cerebral blood flow and metabolism during hemorrhagic hypotension.
Ment L, Stewart W, Duncan C, Pitt B, Rescigno A, Cole J. Beagle puppy model of perinatal cerebral infarction. Acute changes in cerebral blood flow and metabolism during hemorrhagic hypotension. Journal Of Neurosurgery 1985, 63: 441-7. PMID: 3839525, DOI: 10.3171/jns.1985.63.3.0441.Peer-Reviewed Original ResearchConceptsLocal cerebral glucose utilizationCerebral blood flowRegional cerebral blood flowHypotensive insultCerebral infarctionHemorrhagic hypotensionBlood flowUncoupling of CBFMean arterial blood pressureNeonatal cerebral infarctionParieto-occipital white matterPerinatal cerebral infarctionSerum prostaglandin levelsSlow venous hemorrhagePeriventricular white matter regionsAutoradiographic determinationArterial blood pressureCerebral glucose utilizationProstaglandin E2 levelsEffects of hypotensionBeagle puppy modelNewborn beagle pupsGray matter structuresStable breakdown productWhite matter regions
1984
Perinatal cerebral infarction
Ment L, Duncan C, Ehrenkranz R. Perinatal cerebral infarction. Annals Of Neurology 1984, 16: 559-568. PMID: 6508239, DOI: 10.1002/ana.410160506.Peer-Reviewed Original ResearchConceptsPerinatal cerebral infarctionCerebral infarctionNeonatal intraventricular hemorrhageFull-term infantsMonths of ageTwelve-month intervalsPerinatal asphyxiaPreterm neonatesIntraventricular hemorrhageNeonatal seizuresTomographic scanCommon causePostmortem examinationInfarctionInfantsStrokeAsphyxiaHemorrhageNeonatesSeizuresUteroDiagnosisMonths