Featured Publications
Inter-Rater Reliability for the Amputation Endpoint in the National Vascular Quality Initiative
Smolderen K, Romain G, Scierka L, Cleman J, Rahman M, Siddiqui W, Lau F, Mao J, Akhlaghi N, Higaki A, Fowler X, Carroll M, Telma K, Alvermann T, Baribeau V, Goodney P, Mena-Hurtado C. Inter-Rater Reliability for the Amputation Endpoint in the National Vascular Quality Initiative. JACC Cardiovascular Interventions 2024, 17: 622-631. PMID: 38479964, DOI: 10.1016/j.jcin.2024.01.003.Peer-Reviewed Original ResearchConceptsElectronic health recordsElectronic health record reviewAmputation dataPeripheral arterial diseaseInterrater reliabilityVQI registryAcademic health systemTrained data collectorsNational quality registryInter-rater reliabilityEvaluate interrater reliabilityNational reporting systemHealth recordsQuality registryHealth systemCurrent Procedural Terminology codesInter-raterVascular Quality Initiative registryVascular Quality InitiativeProcedural Terminology codesNational Vascular Quality InitiativeRegistryQuality InitiativeAmputationSpearman's r
2023
Comparison of lower extremity bypass and peripheral vascular intervention for chronic limb-threatening ischemia in the Medicare-linked Vascular Quality Initiative
Cleman J, Romain G, Grubman S, Guzman R, Smolderen K, Mena-Hurtado C. Comparison of lower extremity bypass and peripheral vascular intervention for chronic limb-threatening ischemia in the Medicare-linked Vascular Quality Initiative. Journal Of Vascular Surgery 2023, 78: 745-753.e6. PMID: 37207790, PMCID: PMC10964324, DOI: 10.1016/j.jvs.2023.05.015.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaLower extremity bypassPeripheral vascular interventionsVascular Quality InitiativeLimb-threatening ischemiaCause mortalityRisk of deathExtremity bypassVascular interventionsQuality InitiativeCox proportional hazards regressionKaplan-Meier survival curvesProportional hazards regressionOverall mean ageLogistic regression modelsComparative effectiveness researchKnee poplitealMedicare registryInfrapopliteal arteriesHazards regressionMean ageThirty-dayHispanic ethnicityOutcome dataTreatment groups
2022
Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia
Farber A, Menard M, Conte M, Kaufman J, Powell R, Choudhry N, Hamza T, Assmann S, Creager M, Cziraky M, Dake M, Jaff M, Reid D, Siami F, Sopko G, White C, van Over M, Strong M, Villarreal M, McKean M, Azene E, Azarbal A, Barleben A, Chew D, Clavijo L, Douville Y, Findeiss L, Garg N, Gasper W, Giles K, Goodney P, Hawkins B, Herman C, Kalish J, Koopmann M, Laskowski I, Mena-Hurtado C, Motaganahalli R, Rowe V, Schanzer A, Schneider P, Siracuse J, Venermo M, Rosenfield K. Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia. New England Journal Of Medicine 2022, 387: 2305-2316. PMID: 36342173, DOI: 10.1056/nejmoa2207899.Peer-Reviewed Original ResearchMeSH KeywordsChronic Limb-Threatening IschemiaEndovascular ProceduresHumansLimb SalvageRetrospective StudiesRisk FactorsSaphenous VeinTreatment OutcomeVascular Surgical ProceduresConceptsChronic limb-threatening ischemiaMajor adverse limb eventsAdverse limb eventsPrimary outcome eventGreat saphenous veinEndovascular groupSurgical groupSurgical revascularizationEndovascular therapySaphenous veinLimb eventsAdequate greater saphenous veinInfrainguinal peripheral artery diseaseChronic limb threatening ischemiaAlternative bypass conduitLimb threatening ischemiaLimb-threatening ischemiaPeripheral artery diseaseSaphenous vein conduitsRisk of amputationAdverse eventsLimb outcomesArtery diseasePrimary outcomeBypass conduitUse of linked registry claims data for long term surveillance of devices after endovascular abdominal aortic aneurysm repair: observational surveillance study
Goodney P, Mao J, Columbo J, Suckow B, Schermerhorn M, Malas M, Brooke B, Hoel A, Scali S, Arya S, Spangler E, Alabi O, Beck A, Gladders B, Moore K, Zheng X, Eldrup-Jorgensen J, Sedrakyan A, Organization S, Giles K, Beach J, Clouse W, Stone D, Randall M, Mansukhani N, Wang G, Woo K, Mureebe L, Dalsing M, Maijub J, Chaar C, Duwayri Y, Bertges D, Mena-Hurtado C, Smolderen K, Berman S, Osborne N, Henke P, Cronenwett J. Use of linked registry claims data for long term surveillance of devices after endovascular abdominal aortic aneurysm repair: observational surveillance study. The BMJ 2022, 379: e071452. PMID: 36283705, PMCID: PMC9593227, DOI: 10.1136/bmj-2022-071452.Peer-Reviewed Original ResearchConceptsEndovascular abdominal aortic aneurysm repairAbdominal aortic aneurysm repairObservational surveillance studyRisk of reinterventionAortic aneurysm repairLong-term outcomesAFX deviceReal-world practiceAneurysm repairTerm outcomesClaims dataCox modelSurveillance studyVascular Quality Initiative registrySurveillance dataLong-term reinterventionAbdominal aortic aneurysmLong-term surveillanceUnited States MedicareReintervention rateMedian agePost-EVARAortic aneurysmAortic endograftsReinterventionAssociation of depression and anxiety disorders with outcomes after revascularization in chronic limb-threatening ischemia hospitalizations nationwide
Harris KM, Mena-Hurtado C, Burg MM, Vriens PW, Heyligers J, Smolderen KG. Association of depression and anxiety disorders with outcomes after revascularization in chronic limb-threatening ischemia hospitalizations nationwide. Journal Of Vascular Surgery 2022, 77: 480-489. PMID: 36115521, DOI: 10.1016/j.jvs.2022.09.008.Peer-Reviewed Original ResearchConceptsLength of stayChronic limb-threatening ischemiaAnxiety disorder diagnosisAssociation of depressionRevascularization cohortMajor amputationDisorder diagnosisSurgical revascularizationEndovascular revascularizationHigher oddsLonger median LOSMedian LOSLonger LOSAnxiety disordersDocumentation of depressionPeripheral artery diseaseLimb-threatening ischemiaRisk of amputationNational Inpatient SamplePatients' sociodemographic dataHigher median costArtery diseaseIllness severityPsychiatric comorbidityComorbid depressionMajor Adverse Limb Events Among Patients with Premature Peripheral Artery Disease Compared with Those at the Common Age Undergoing Revascularization in the Vascular Quality Initiative
Kim TI, Loh S, DeWan A, Murray M, Mojibian H, Mani A, Mena-Hurtado C, Ochoa Chaar CI. Major Adverse Limb Events Among Patients with Premature Peripheral Artery Disease Compared with Those at the Common Age Undergoing Revascularization in the Vascular Quality Initiative. Annals Of Vascular Surgery 2022, 87: 188-197. PMID: 35926786, DOI: 10.1016/j.avsg.2022.07.007.Peer-Reviewed Original ResearchConceptsMajor adverse limb eventsChronic limb-threatening ischemiaLower extremity revascularizationAdverse limb eventsVascular Quality InitiativePeripheral artery diseaseYears of ageCommon ageLimb eventsArtery diseaseOutcomes of patientsLimb-threatening ischemiaGroup of patientsInsulin-dependent diabetesProportional hazards regressionQuality InitiativeUndergoing revascularizationMedical optimizationCurrent smokersD diseaseExtremity revascularizationPatient agePatients 60Medical therapyHazards regressionThe Impact of Clinical Follow-Up After Revascularization on the Outcomes of Patients with Chronic Limb Threatening Ischemia
Kiwan G, Mohamedali A, Kim T, Zhuo H, Zhang Y, Mena-Hurtado C, Mojibian H, Cardella J, Ochoa Chaar CI. The Impact of Clinical Follow-Up After Revascularization on the Outcomes of Patients with Chronic Limb Threatening Ischemia. Annals Of Vascular Surgery 2022, 86: 286-294. PMID: 35803459, DOI: 10.1016/j.avsg.2022.05.043.Peer-Reviewed Original ResearchConceptsLower extremity revascularizationReintervention rateCompliant patientsNoncompliant patientsLimb amputationSingle-center retrospective chart reviewChronic limb threatening ischemiaOverall reintervention rateOutcomes of patientsLimb threatening ischemiaMajor amputation ratePeripheral arterial diseaseRetrospective chart reviewLong-term outcomesMajor limb amputationImpact of ClinicalSignificant differencesMajor amputationAmputation ratePerioperative outcomesBaseline characteristicsChart reviewExtremity revascularizationIschemia patientsMore reinterventionsVariability in 30-day major amputation rates following endovascular peripheral vascular intervention for critical limb ischemia
Provance JB, Spertus JA, Jones PG, Hoffman MA, Bunte MC, Vogel TR, Mena-Hurtado C, Smolderen KG. Variability in 30-day major amputation rates following endovascular peripheral vascular intervention for critical limb ischemia. Vascular Medicine 2022, 27: 350-357. PMID: 35603755, DOI: 10.1177/1358863x221098097.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsCritical limb ischemiaMedian risk ratioEndovascular peripheral vascular interventionsMajor amputation ratePatient-level factorsAmputation ratePVI procedureLimb ischemiaRisk ratioVascular interventionsNational electronic health record databaseElectronic health record databasePredictors of amputationRate of amputationMixed effects Poisson regression modelHealth record databaseEffects Poisson regression modelPoisson regression modelsCLI carePrevious amputationClinical factorsCLI treatmentBlack raceDiagnosis codesImpact of malnutrition and frailty on mortality and major amputation in patients with CLTI
Karim AM, Li J, Panhwar MS, Arshad S, Shalabi S, Mena‐Hurtado C, Aronow HD, Secemsky EA, Shishehbor MH. Impact of malnutrition and frailty on mortality and major amputation in patients with CLTI. Catheterization And Cardiovascular Interventions 2022, 99: 1300-1309. PMID: 35114067, DOI: 10.1002/ccd.30113.Peer-Reviewed Original ResearchConceptsFrail patientsMajor amputationFrailty Risk ScoreClinical Modification codesImpact of malnutritionManagement of frailtyNational Inpatient SamplePrevalence of malnutritionMultivariable regression analysisOutcomes of interestCLTI patientsHospital mortalityEndovascular revascularizationMortality benefitAdverse eventsFrailty statusRevascularization methodInpatient SampleHospital costsInvasive approachRisk scoreInternational ClassificationCLTIPatientsNutritional status
2021
Lack of Guideline-Directed Medical Therapy in Patients Undergoing Endovascular Procedures for Critical Limb Ischemia
Llanos-Chea F, Jelani QU, Trejo-Paredes C, Curtis JP, Parzynski CS, Huang J, Faridi KF, Turner J, Smolderen KG, Mena-Hurtado C. Lack of Guideline-Directed Medical Therapy in Patients Undergoing Endovascular Procedures for Critical Limb Ischemia. Journal Of The American College Of Cardiology 2021, 77: 1374-1375. PMID: 33706882, DOI: 10.1016/j.jacc.2020.12.063.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsCohort StudiesEndovascular ProceduresFemaleGuideline AdherenceHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIschemiaMaleMiddle AgedPeripheral Arterial DiseasePlatelet Aggregation InhibitorsSafety and efficacy outcomes of the Pioneer Plus catheter in endovascular revascularization of lower extremity chronic total occlusions
Sheikh AB, Llanos-Chea F, Jelani QU, Anantha-Narayanan M, Attaran R, Schneider M, Ionescu C, Regan C, Nagpal S, Smolderen KG, Mena-Hurtado C. Safety and efficacy outcomes of the Pioneer Plus catheter in endovascular revascularization of lower extremity chronic total occlusions. Journal Of Vascular Surgery 2021, 74: 746-755. PMID: 33592298, DOI: 10.1016/j.jvs.2021.01.045.Peer-Reviewed Original ResearchConceptsMajor adverse limb eventsAdverse limb eventsDevice-related complicationsProcedure-related complicationsProcedure-related outcomesProcedural successEfficacy outcomesPseudoaneurysm formationSafety outcomesLimb eventsLower extremity chronic total occlusionMajor adverse cardiovascular eventsChronic total occlusion interventionAccess site hematomaAcute arterial thrombosisAcute limb ischemiaAdverse cardiovascular eventsProvider-level factorsArteriovenous fistula formationHigh-volume centersChronic total occlusionMajor bleedingPreprocedural symptomsCardiovascular eventsCatheter useContemporary Trends in Hospital Admissions and Outcomes in Patients With Critical Limb Ischemia
Anantha-Narayanan M, Doshi RP, Patel K, Sheikh AB, Llanos-Chea F, Abbott JD, Shishehbor MH, Guzman RJ, Hiatt WR, Duval S, Mena-Hurtado C, Smolderen KG. Contemporary Trends in Hospital Admissions and Outcomes in Patients With Critical Limb Ischemia. Circulation Cardiovascular Quality And Outcomes 2021, 14: e007539. PMID: 33541110, DOI: 10.1161/circoutcomes.120.007539.Peer-Reviewed Original ResearchConceptsLength of stayMajor amputationCost of hospitalizationHospital mortalitySurgical interventionEndovascular interventionBlack raceHigh-risk patient profileNational Inpatient Sample dataHigher major amputationMore endovascular interventionsRisk patient profileCritical limb ischemiaOpen surgical interventionMultivariable regression analysisHierarchical multivariable regression analysisCLI cohortHospital admissionLimb ischemiaPrimary outcomeRevascularization proceduresSecondary outcomesAtherosclerotic diseaseMale sexFemale sex
2020
Physical Activity After Treatment for Symptomatic Peripheral Artery Disease
Peri-Okonny PA, Patel S, Spertus JA, Jackson EA, Malik AO, Provance J, Mena-Hurtado C, Shishehbor MH, Hijjaji V, Gosch KL, Smolderen K. Physical Activity After Treatment for Symptomatic Peripheral Artery Disease. The American Journal Of Cardiology 2020, 138: 107-113. PMID: 33065083, PMCID: PMC7736254, DOI: 10.1016/j.amjcard.2020.10.011.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnkle Brachial IndexConservative TreatmentEndovascular ProceduresExerciseExercise TherapyFemaleHealth StatusHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIntermittent ClaudicationLeisure ActivitiesLinear ModelsLogistic ModelsMaleMiddle AgedMultivariate AnalysisPatient SatisfactionPeripheral Arterial DiseasePlatelet Aggregation InhibitorsQuality of LifeSedentary BehaviorSmoking CessationSocial InteractionVascular Surgical ProceduresWorkConceptsPhysical activity levelsPhysical activityInvasive treatmentSymptomatic peripheral artery diseasePeripheral artery diseaseMultivariable logistic regressionAssociation of treatmentActivity levelsMultivariable linear regressionHealth status changesHealth status gainsPAD outcomesArtery diseaseVascular clinicInvasive groupNoninvasive treatmentHealth statusLogistic regressionActivity statusLTPAClaudicationTreatmentPatientsStatus changesAssociationOutcomes of treatment with paclitaxel-coated devices for peripheral arterial disease
Kim TI, Kiwan G, Mohamedali A, Zhang Y, Mena-Hurtado C, Mojibian H, Guzman RJ, Ochoa Chaar CI. Outcomes of treatment with paclitaxel-coated devices for peripheral arterial disease. Journal Of Vascular Surgery 2020, 73: 911-917. PMID: 33038480, DOI: 10.1016/j.jvs.2020.08.146.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAmputation, SurgicalCardiovascular AgentsCoated Materials, BiocompatibleDrug-Eluting StentsEndovascular ProceduresFemaleHumansLimb SalvageMaleMiddle AgedPaclitaxelPeripheral Arterial DiseaseProsthesis DesignRetreatmentRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeVascular PatencyConceptsPaclitaxel-coated devicesPeripheral artery diseaseCause of mortalityPCD useRisk of mortalityCumulative doseFemoropopliteal peripheral artery diseaseKaplan-Meier survival curvesLong-term mortalityPeripheral arterial diseaseCox regression analysisDrug-coated balloonsOutcome of treatmentDrug-eluting stentsMajor amputationPrimary patencyReintervention rateArtery diseaseArterial diseaseRandomized trialsOpen surgeryPresent studySingle institutionEndovascular interventionPatientsSystematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease
Anantha-Narayanan M, Sheikh AB, Nagpal S, Jelani QU, Smolderen KG, Regan C, Ionescu C, Ochoa Chaar CI, Schneider M, Llanos-Chea F, Mena-Hurtado C. Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease. Journal Of Vascular Surgery 2020, 73: 331-340.e4. PMID: 32889074, DOI: 10.1016/j.jvs.2020.08.032.Peer-Reviewed Original ResearchMeSH KeywordsEndovascular ProceduresHumansKidney Failure, ChronicLower ExtremityPeripheral Arterial DiseaseRenal Insufficiency, ChronicRisk FactorsConceptsCKD/end-stage renal diseaseEnd-stage renal diseaseNormal renal functionChronic kidney diseaseTarget lesion revascularizationLong-term mortalityPeripheral arterial diseaseRenal functionPAD interventionsMajor amputationRenal diseaseKidney diseaseOdds ratioNormal renal function groupIntervention typeRenal function groupCritical limb ischemiaPeripheral arterial interventionsConfidence intervalsPooled odds ratioOpen surgical approachMultivariable regression analysisCase-control matchingRandom-effects modelEvidence-based strategiesUtility of Intravascular Ultrasound in Peripheral Vascular Interventions: Systematic Review and Meta-Analysis
Sheikh AB, Anantha-Narayanan M, Smolderen KG, Jelani QU, Nagpal S, Schneider M, Llanos F, Ionescu C, Regan C, Attaran R, Altin SE, Mena-Hurtado C. Utility of Intravascular Ultrasound in Peripheral Vascular Interventions: Systematic Review and Meta-Analysis. Vascular And Endovascular Surgery 2020, 54: 413-422. PMID: 32338163, DOI: 10.1177/1538574420920998.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsPeriprocedural adverse eventsVascular complicationsAdverse eventsIntravascular ultrasoundPrimary patencyCause mortalityTechnical successMyocardial infarctionObservational studyVascular interventionsEnd pointSimilar patency ratesSimilar primary patencyPrimary end pointRate of reinterventionSecondary end pointsPeripheral arterial diseaseImproved clinical outcomesIVUS groupAmputation rateArterial diseaseClinical outcomesPatency ratesLower risk
2019
Evaluation of anticoagulant and antiplatelet therapy after iliocaval stenting: Factors associated with stent occlusion
Attaran RR, Ozdemir D, Lin IH, Mena-Hurtado C, Lansky A. Evaluation of anticoagulant and antiplatelet therapy after iliocaval stenting: Factors associated with stent occlusion. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2019, 7: 527-534. PMID: 31203859, DOI: 10.1016/j.jvsv.2019.01.058.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnticoagulantsEndovascular ProceduresFemaleHumansIliac VeinMaleMay-Thurner SyndromeMiddle AgedPlatelet Aggregation InhibitorsPostthrombotic SyndromeProsthesis DesignRecurrenceRetrospective StudiesStentsTime FactorsTreatment OutcomeVascular PatencyVena Cava, InferiorVenous ThrombosisConceptsAcute deep vein thrombosisPost-thrombotic syndromeDeep vein thrombosisMay-Thurner syndromeDuration of anticoagulationAntiplatelet therapyPatency ratesIliocaval stentingIpsilateral deep vein thrombosisIliocaval venous stentingPrimary patency rateStent patency ratesCommon femoral veinVariety of indicationsLarge teaching hospitalVein thrombosisVenous stentingRetrospective reviewDVT groupStent groupFemoral veinProcedural dataStent patencyStent occlusionTeaching hospitalEndovascular Treatment of Inferior Vena Cava Thrombosis in Metastatic Malignancy: A Case Report and Review of Literature
Shapero KS, Jelani QU, Mena C. Endovascular Treatment of Inferior Vena Cava Thrombosis in Metastatic Malignancy: A Case Report and Review of Literature. Vascular And Endovascular Surgery 2019, 53: 507-511. PMID: 31216954, DOI: 10.1177/1538574419857992.Peer-Reviewed Original ResearchConceptsInferior vena cava thrombosisLower extremity edemaVena cava thrombosisAcute liver failureRight atriumIVC thrombosisCava thrombosisExtremity edemaLiver failureSevere bilateral lower extremity edemaBilateral lower extremity edemaAdrenal cell carcinomaExtensive clot burdenExtensive IVC thrombosisMetastatic liver massesDeep vein thrombosisClot burdenIVC syndromeReview of literatureGastrointestinal bleedHospital courseVein thrombosisHepatic failureCaudate lobeEndovascular treatmentMultidisciplinary Care for Critical Limb Ischemia: Current Gaps and Opportunities for Improvement
Armstrong EJ, Alam S, Henao S, Lee AC, DeRubertis BG, Montero-Baker M, Mena C, Cua B, Palena LM, Kovach R, Chandra V, AlMahameed A, Walker CM. Multidisciplinary Care for Critical Limb Ischemia: Current Gaps and Opportunities for Improvement. Journal Of Endovascular Therapy 2019, 26: 199-212. PMID: 30706755, DOI: 10.1177/1526602819826593.Peer-Reviewed Original ResearchConceptsCritical limb ischemiaCare of patientsComplex patient populationMultidisciplinary careLimb ischemiaPatient populationIschemic rest painLimb-related morbidityPeripheral artery diseaseFacets of careRest painArterial insufficiencyRevascularization strategyArtery diseaseTimely referralSingle medical specialtyOptimal treatmentPatient outcomesSocietal guidelinesWound careTreatment teamMultiple specialtiesPatientsCareMedical specialties
2018
Increased mortality in octogenarians treated for lifestyle limiting claudication
Erben Y, Mena‐Hurtado C, Miller S, Jean R, Sumpio BJ, Velasquez CA, Mojibian H, Aruny J, Dardik A, Sumpio B. Increased mortality in octogenarians treated for lifestyle limiting claudication. Catheterization And Cardiovascular Interventions 2018, 91: 1331-1338. PMID: 29405592, DOI: 10.1002/ccd.27523.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overComorbidityDatabases, FactualEndovascular ProceduresFemaleHealth StatusHumansIntermittent ClaudicationLength of StayMaleMiddle AgedPeripheral Arterial DiseaseRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeUnited StatesVascular Surgical ProceduresConceptsCharlson Comorbidity IndexOpen surgeryTreatment modalitiesHigher Charlson comorbidity indexMean Charlson Comorbidity IndexYounger cohortsInfectious wound complicationsInfra-inguinal interventionsAcute kidney injuryPeripheral arterial diseasePeripheral artery diseaseCongestive heart failureNationwide Inpatient SampleBinary logistic regression analysisLogistic regression analysisSkilled nursing facilitiesTreatment of LLCHospital mortalityComorbidity indexExercise therapyHospital stayKidney injuryOverall morbidityWound complicationsLonger LOS