2022
Psychosocial Stress and Hypothalamic-Pituitary-Adrenal Axis Stress Reactivity: Variations by Race and Socioeconomic Status Among Adults at Risk of Diabetes
Kalesnikava V, Clarke P, Mukherjee B, Sen S, Mezuk B. Psychosocial Stress and Hypothalamic-Pituitary-Adrenal Axis Stress Reactivity: Variations by Race and Socioeconomic Status Among Adults at Risk of Diabetes. Psychosomatic Medicine 2022, 84: 813-821. PMID: 35980779, DOI: 10.1097/psy.0000000000001112.Peer-Reviewed Original ResearchConceptsDomain-specific stressMeasures of psychosocial stressTrier Social Stress TestAssociated with cortisol recoveryHypothalamic-pituitary-adrenal axis reactivityPsychosocial stressPerceived stressEvidence of effect modificationCortisol responseHigh-SES neighborhoodsHigher perceived stressPsychosocial stress measuresSocioeconomically diverse cohortCortisol recoveryRisk of diabetesAssociated with cortisol responseNeighborhood SESHealth disparitiesEffect modificationNeurobiological stress responseSocioeconomic statusSocial Stress TestSelf-report measuresType 2 diabetesSalivary cortisol response
2015
Association between Stress Response Genes and Features of Diurnal Cortisol Curves in the Multi-Ethnic Study of Atherosclerosis: A New Multi-Phenotype Approach for Gene-Based Association Tests
He Z, Payne E, Mukherjee B, Lee S, Smith J, Ware E, Sánchez B, Seeman T, Kardia S, Roux A. Association between Stress Response Genes and Features of Diurnal Cortisol Curves in the Multi-Ethnic Study of Atherosclerosis: A New Multi-Phenotype Approach for Gene-Based Association Tests. PLOS ONE 2015, 10: e0126637. PMID: 25993632, PMCID: PMC4439141, DOI: 10.1371/journal.pone.0126637.Peer-Reviewed Original ResearchConceptsMulti-Ethnic Study of AtherosclerosisMarker association testsCortisol featuresMulti-Ethnic StudySingle marker association testsStudy of AtherosclerosisAssociation TestGene level association testsGene-based association testsEthnic-specific resultsMeta-analysisGenetic contribution to variabilityGene-level analysisStress-responsive genesSample of European AmericansGenotype-phenotype associationsDiurnal cortisol curveHispanic AmericansChronic diseasesMultiple physiological systemsDaily cortisol profilesAfrican AmericansGene approachGene-basedMultiple testing