Featured Publications
Exploring the Big Data Paradox for various estimands using vaccination data from the global COVID-19 Trends and Impact Survey (CTIS)
Yang Y, Dempsey W, Han P, Deshmukh Y, Richardson S, Tom B, Mukherjee B. Exploring the Big Data Paradox for various estimands using vaccination data from the global COVID-19 Trends and Impact Survey (CTIS). Science Advances 2024, 10: eadj0266. PMID: 38820165, PMCID: PMC11314312, DOI: 10.1126/sciadv.adj0266.Peer-Reviewed Original ResearchCharacteristics Associated With Racial/Ethnic Disparities in COVID-19 Outcomes in an Academic Health Care System
Gu T, Mack J, Salvatore M, Sankar S, Valley T, Singh K, Nallamothu B, Kheterpal S, Lisabeth L, Fritsche L, Mukherjee B. Characteristics Associated With Racial/Ethnic Disparities in COVID-19 Outcomes in an Academic Health Care System. JAMA Network Open 2020, 3: e2025197. PMID: 33084902, PMCID: PMC7578774, DOI: 10.1001/jamanetworkopen.2020.25197.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBetacoronavirusBlack or African AmericanComorbidityCoronavirus InfectionsCOVID-19Diabetes Mellitus, Type 2FemaleHealth Status DisparitiesHospitalizationHumansIntensive Care UnitsKidney DiseasesMaleMichiganMiddle AgedNeoplasmsObesityOdds RatioPandemicsPneumonia, ViralPopulation DensityRetrospective StudiesRisk FactorsSARS-CoV-2White PeopleConceptsAssociated with higher riskInternational Classification of DiseasesRisk of hospitalizationPreexisting type 2 diabetesHigher risk of hospitalizationClassification of DiseasesType 2 diabetesCOVID-19 outcomesRacial/ethnic disparitiesWhite patientsBlack patientsIntensive care unitInternational ClassificationResidential-level socioeconomic characteristicsOdds ratioStatistically significant racial differencesHigh riskAssociated with higher risk of hospitalizationNon-Hispanic blacksAssociation of risk factorsNon-Hispanic whitesMichigan Department of HealthAssociated with increased risk of hospitalizationComorbidity scoreDepartment of HealthRisk of Non-Melanoma Cancers in First-Degree Relatives of CDKN2A Mutation Carriers
Mukherjee B, DeLancey J, Raskin L, Everett J, Jeter J, Begg C, Orlow I, Berwick M, Armstrong B, Kricker A, Marrett L, Millikan R, Culver H, Rosso S, Zanetti R, Kanetsky P, From L, Gruber S, Investigators F. Risk of Non-Melanoma Cancers in First-Degree Relatives of CDKN2A Mutation Carriers. Journal Of The National Cancer Institute 2012, 104: 953-956. PMID: 22534780, PMCID: PMC3379723, DOI: 10.1093/jnci/djs221.Peer-Reviewed Original ResearchConceptsFirst-degree relatives of carriersCDKN2A mutation carriersFirst-degree relativesMutation carriersNon-melanoma cancersFirst-degree relatives of melanoma patientsFirst-degree relatives of mutation carriersKin-cohort methodConfidence intervalsRisk of cancerMelanoma patientsLifetime riskProband's genotypeNon-melanomaFamily membersIncreased riskGastrointestinal cancerCDKN2A mutationsWilms tumorRiskMelanoma StudyPancreatic cancerNoncarriersGenotype distributionMelanoma
2024
Cross-shift changes in pulmonary function and occupational exposure to particulate matter among e-waste workers in Ghana
Laskaris Z, O'Neill M, Batterman S, Mukherjee B, Fobil J, Robins T. Cross-shift changes in pulmonary function and occupational exposure to particulate matter among e-waste workers in Ghana. Frontiers In Public Health 2024, 12: 1368112. PMID: 38784567, PMCID: PMC11111984, DOI: 10.3389/fpubh.2024.1368112.Peer-Reviewed Original ResearchConceptsE-waste workersExposure to particulate matterE-wasteParticulate matterAgbogbloshie e-waste siteInhalation exposure to particulate matterE-waste sitesBurning e-wasteConcentrations of PMHealth-based guidelinesExposure to airborne pollutantsExposure to PMOccupational exposure to particulate matterCross-shift changesElectronic-wasteForced vital capacityPersonal PMPM exposureAirborne pollutantsLinear mixed modelsBreathing zone concentrationsPulmonary functionComparison populationRecovery workersMixed modelsCross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts
Suthar H, Manea T, Pak D, Woodbury M, Eick S, Cathey A, Watkins D, Strakovsky R, Ryva B, Pennathur S, Zeng L, Weller D, Park J, Smith S, DeMicco E, Padula A, Fry R, Mukherjee B, Aguiar A, Geiger S, Ng S, Huerta-Montanez G, Vélez-Vega C, Rosario Z, Cordero J, Zimmerman E, Woodruff T, Morello-Frosch R, Schantz S, Meeker J, Alshawabkeh A, Aung M, Outcomes O. Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts. Environmental Science And Technology 2024, 58: 8264-8277. PMID: 38691655, PMCID: PMC11097396, DOI: 10.1021/acs.est.4c00094.Peer-Reviewed Original ResearchConceptsPFAS mixtureLinear mixed modelsBioactive lipidsChild health outcomesCross-sectional associationsPrenatal PFAS exposureBioactive lipid levelsPoly-fluoroalkyl substancesQuantile g-computationMixed modelsGestational outcomesHealth outcomesPregnancy outcomesPregnant womenCombined cohortG-computationCohort analysisProgram cohortQuartile increaseLipid levelsCohortPositive associationMeta-analysisEnvironmental influencesPFAS exposureAssociations of maternal blood metal concentrations with plasma eicosanoids among pregnant women in Puerto Rico
Kim C, Cathey A, Park S, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Associations of maternal blood metal concentrations with plasma eicosanoids among pregnant women in Puerto Rico. The Science Of The Total Environment 2024, 928: 172295. PMID: 38588744, DOI: 10.1016/j.scitotenv.2024.172295.Peer-Reviewed Original ResearchConceptsAdverse birth outcomesSex-specific associationsBirth outcomesBlood metal concentrationsMetal concentrationsPregnant womenInfant sexEicosanoid profileMetal exposurePlasma eicosanoidsWeeks of pregnancyDecreased concentrations of CdConcentrations of CdConcentrations of CuEffect modificationRegulating inflammatory responsesBirth cohortAssessed associationsAssociated with increased concentrationsPregnancy outcomesFemale fetusesEffect sizeInflammatory activitySignificant associationInflammatory response
2023
Evaluating Educational Outcomes Using Patient Outcomes of New Surgeons Performing Partial Colectomy Compared to Cholecystectomy
George B, Thelen A, Howard R, Kendrick D, Chen X, Clark M, Gupta T, Brown C, Bandeh-Ahmadi H, Luckoski J, Wnuk G, Fan Z, Krumm A, Ryan A, Buyske J, Mukherjee B, Dimick J. Evaluating Educational Outcomes Using Patient Outcomes of New Surgeons Performing Partial Colectomy Compared to Cholecystectomy. Academic Medicine 2023, 98: s143-s148. PMID: 37983406, DOI: 10.1097/acm.0000000000005368.Peer-Reviewed Original ResearchConceptsPartial colectomyPatient outcomesYears of practiceExperienced surgeonSurgeon yearsRisk-adjusted ratesCholecystectomyColectomyTraining of surgeonsInpatient cholecystectomyComplicationsImprove surgical educationPatientsEvaluate educational outcomesSurgeonsSurgical residentsBenefit patientsInpatient operationsResidency trainingStudy periodDeathOutcomesSurgical educationMixed modelsTraining
2022
Methods for large‐scale single mediator hypothesis testing: Possible choices and comparisons
Du J, Zhou X, Clark‐Boucher D, Hao W, Liu Y, Smith J, Mukherjee B. Methods for large‐scale single mediator hypothesis testing: Possible choices and comparisons. Genetic Epidemiology 2022, 47: 167-184. PMID: 36465006, PMCID: PMC10329872, DOI: 10.1002/gepi.22510.Peer-Reviewed Original ResearchConceptsNull hypothesisTest statisticsMediation hypothesis testingComposite null hypothesisHypothesis testingClasses of methodsFalse positive rateAlternative hypothesisSimulation studyHypothesis testing methodContinuous mediatorReference distributionSobel test statisticsContinuous outcomesExposure-mediator interactionMulti-Ethnic Study of AtherosclerosisDNA methylation sitesClassCRANMethylation sitesPersistent organic pollutant exposure contributes to Black/White differences in leukocyte telomere length in the National Health and Nutrition Examination Survey
Roberts E, Boss J, Mukherjee B, Salerno S, Zota A, Needham B. Persistent organic pollutant exposure contributes to Black/White differences in leukocyte telomere length in the National Health and Nutrition Examination Survey. Scientific Reports 2022, 12: 19960. PMID: 36402910, PMCID: PMC9675834, DOI: 10.1038/s41598-022-24316-0.Peer-Reviewed Original ResearchConceptsNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyPersistent organic pollutantsLeukocyte telomere lengthNutrition Examination SurveyToxic equivalent quotientPolychlorinated biphenylsBlack/white differencesExamination SurveyCross-sectional National Health and Nutrition Examination SurveyNon-Hispanic Black AmericansExposure scoreNon-Hispanic white AmericansSurvey-weighted linear regression modelsIndirect effects of raceAssociated with longer leukocyte telomere lengthSingle-pollutant modelsIndividual persistent organic pollutantsExposure to polychlorinated biphenylsLonger leukocyte telomere lengthSelf-reported racePersistent organic pollutant exposuresBlack AmericansIndividual polychlorinated biphenylOrganic pollutant exposuresPsychosocial Stress and Hypothalamic-Pituitary-Adrenal Axis Stress Reactivity: Variations by Race and Socioeconomic Status Among Adults at Risk of Diabetes
Kalesnikava V, Clarke P, Mukherjee B, Sen S, Mezuk B. Psychosocial Stress and Hypothalamic-Pituitary-Adrenal Axis Stress Reactivity: Variations by Race and Socioeconomic Status Among Adults at Risk of Diabetes. Psychosomatic Medicine 2022, 84: 813-821. PMID: 35980779, DOI: 10.1097/psy.0000000000001112.Peer-Reviewed Original ResearchConceptsDomain-specific stressMeasures of psychosocial stressTrier Social Stress TestAssociated with cortisol recoveryHypothalamic-pituitary-adrenal axis reactivityPsychosocial stressPerceived stressEvidence of effect modificationCortisol responseHigh-SES neighborhoodsHigher perceived stressPsychosocial stress measuresSocioeconomically diverse cohortCortisol recoveryRisk of diabetesAssociated with cortisol responseNeighborhood SESHealth disparitiesEffect modificationNeurobiological stress responseSocioeconomic statusSocial Stress TestSelf-report measuresType 2 diabetesSalivary cortisol response
2021
Perfluoroalkyl and polyfluoroalkyl substances and body size and composition trajectories in midlife women: the study of women’s health across the nation 1999–2018
Ding N, Karvonen-Gutierrez C, Herman W, Calafat A, Mukherjee B, Park S. Perfluoroalkyl and polyfluoroalkyl substances and body size and composition trajectories in midlife women: the study of women’s health across the nation 1999–2018. International Journal Of Obesity 2021, 45: 1937-1948. PMID: 33986457, PMCID: PMC8384652, DOI: 10.1038/s41366-021-00848-9.Peer-Reviewed Original ResearchConceptsWaist circumferenceMidlife womenFat massLowest tertileAssociated with greater body sizeStudy of women's healthResultsAfter multivariable adjustmentAssociated with accelerated increaseTrajectories of weightAssociated with weightSubjects/MethodsThis studyWomen's HealthObesity riskFollow-upDual-energy X-ray absorptiometryLinear mixed modelsHighest tertileX-ray absorptiometryGreater body sizeMultivariable adjustmentBody fatEpidemiological evidenceNo significant resultsBody compositionAverage follow-upIncorporating false negative tests in epidemiological models for SARS-CoV-2 transmission and reconciling with seroprevalence estimates
Bhattacharyya R, Kundu R, Bhaduri R, Ray D, Beesley L, Salvatore M, Mukherjee B. Incorporating false negative tests in epidemiological models for SARS-CoV-2 transmission and reconciling with seroprevalence estimates. Scientific Reports 2021, 11: 9748. PMID: 33963259, PMCID: PMC8105357, DOI: 10.1038/s41598-021-89127-1.Peer-Reviewed Original ResearchMaternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates
Aung M, Ashrap P, Watkins D, Mukherjee B, Rosario Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates. Scientific Reports 2021, 11: 8115. PMID: 33854141, PMCID: PMC8046995, DOI: 10.1038/s41598-021-87472-9.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthBiomarkers of pregnancy outcomesGestational age neonatesPreterm birthAge neonatesPregnancy outcomesDegree of hydrocarbon chain saturationIncreased riskNeonatal anthropometric parametersAssociated with increased riskPlasmenyl phosphatidylethanolamineMaternal lipidomeWeeks gestationGestational ageLipidomic signatureAnthropometric parametersLiquid chromatography tandem mass spectrometryLipidomic profilesLipid metabolitesHydrocarbon chain saturationPlasma samplesBirthLogistic regressionHigh-performance liquid chromatography tandem mass spectrometryNeonatesDepot-Medroxyprogesterone Acetate Use Is Associated with Decreased Risk of Ovarian Cancer: The Mounting Evidence of a Protective Role of ProgestinsDMPA Use Decreases Ovarian Cancer Risk
Phung M, Lee A, Wu A, Berchuck A, Cho K, Cramer D, Doherty J, Goodman M, Hanley G, Harris H, McLean K, Modugno F, Moysich K, Mukherjee B, Schildkraut J, Terry K, Titus L, Consortium O, Jordan S, Webb P, Consortium O, Pike M, Pearce C. Depot-Medroxyprogesterone Acetate Use Is Associated with Decreased Risk of Ovarian Cancer: The Mounting Evidence of a Protective Role of ProgestinsDMPA Use Decreases Ovarian Cancer Risk. Cancer Epidemiology Biomarkers & Prevention 2021, 30: 927-935. PMID: 33619020, PMCID: PMC9281627, DOI: 10.1158/1055-9965.epi-20-1355.Peer-Reviewed Original ResearchConceptsOvarian cancer riskDepot medroxyprogesterone acetate useRisk of ovarian cancerDepot medroxyprogesterone acetateCancer riskOvarian cancerDecreased riskInverse associationRisk of invasive epithelial ovarian cancerRisk of ovarian cancer overallAssociated with decreased risk of ovarian cancerDecreased risk of ovarian cancerOvarian Cancer Association ConsortiumDecreased ovarian cancer riskSystematic reviewOvarian cancer overallInvasive epithelial ovarian cancerAssociated with decreased riskCombined oral contraceptive useInjectable progestin-only contraceptivesProgestin-only contraceptive useProgestin-releasing intrauterine deviceContraceptive useAssociated with ovarian cancerProgestin-only contraceptivesExposure and risk factors for COVID-19 and the impact of staying home on Michigan residents
Wu K, Hornsby W, Klunder B, Krause A, Driscoll A, Kulka J, Bickett-Hickok R, Fellows A, Graham S, Kaleba E, Hayek S, Shi X, Sutton N, Douville N, Mukherjee B, Jamerson K, Brummett C, Willer C. Exposure and risk factors for COVID-19 and the impact of staying home on Michigan residents. PLOS ONE 2021, 16: e0246447. PMID: 33556117, PMCID: PMC7870003, DOI: 10.1371/journal.pone.0246447.Peer-Reviewed Original ResearchConceptsAfrican AmericansAnnual household income <Worsening health behaviorsLong-term health outcomesHousehold income <Low socioeconomic statusExposure to family membersHigher overall concernHigh riskExposure to familyHigh risk of contracting COVID-19Positive COVID-19 testLow-income groupsHealth behaviorsHealth outcomesRates of COVID-19 casesRental housingSocioeconomic statusClinical careRisk of contracting COVID-19COVID-19 preventionChronic diseasesInequality gapState of MichiganCOVID-19 cases
2020
Application of an analytical framework for multivariate mediation analysis of environmental data
Aung M, Song Y, Ferguson K, Cantonwine D, Zeng L, McElrath T, Pennathur S, Meeker J, Mukherjee B. Application of an analytical framework for multivariate mediation analysis of environmental data. Nature Communications 2020, 11: 5624. PMID: 33159049, PMCID: PMC7648785, DOI: 10.1038/s41467-020-19335-2.Peer-Reviewed Original ResearchDo black/white differences in telomere length depend on socioeconomic status?
Needham B, Salerno S, Roberts E, Boss J, Allgood K, Mukherjee B. Do black/white differences in telomere length depend on socioeconomic status? Biodemography And Social Biology 2020, 65: 287-312. PMID: 33243026, PMCID: PMC7703670, DOI: 10.1080/19485565.2020.1765734.Peer-Reviewed Original ResearchConceptsUS blacksNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyNutrition Examination SurveyAccelerated biological agingLeukocyte telomere lengthLonger telomere lengthExamination SurveyRisk of diseaseSocioeconomic statusHigher SESLow SESMiddle SESBlack/white differencesTelomere lengthRace differencesSESEconomic disadvantageBiological ageWhiteGenetic explanationBlackHealthDifferencesSurveyCancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks
Fritsche L, Patil S, Beesley L, VandeHaar P, Salvatore M, Ma Y, Peng R, Taliun D, Zhou X, Mukherjee B. Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks. American Journal Of Human Genetics 2020, 107: 815-836. PMID: 32991828, PMCID: PMC7675001, DOI: 10.1016/j.ajhg.2020.08.025.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresGenome-wide association studiesMichigan Genomics InitiativeUK BiobankPopulation-based UK BiobankPolygenic risk score constructionPublished genome-wide association studiesLongitudinal biorepository effortAssociation studiesPredictive polygenic risk scoresRisk scoreNHGRI-EBI GWAS CatalogCancer traitsIndependent biobankMichigan MedicineGWAS CatalogGenome InitiativeBiobankScoresTraitsCancer researchOnline repositoryMichiganMedicineEvaluation
2019
Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals
Aung M, Meeker J, Boss J, Bakulski K, Mukherjee B, Cantonwine D, McElrath T, Ferguson K. Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals. Reproductive Toxicology 2019, 93: 43-53. PMID: 31881266, PMCID: PMC7138746, DOI: 10.1016/j.reprotox.2019.12.004.Peer-Reviewed Original ResearchConceptsIL-1BBayesian kernel machine regressionKernel machine regressionInterleukin-1bInterquartile range differenceCross-sectional studyAssociated with biomarkersReproductive health outcomesImmune signaling moleculesHealth outcomesLIFECODES birth cohortPregnant womenImmune perturbationsImmune biomarkersBirth cohortUrinary manganeseMachine regressionLinear regressionExposure analytesAssociationSignaling moleculesRegressionPair-wise associationsTrimesterPregnancyPrediction and associations of preterm birth and its subtypes with eicosanoid enzymatic pathways and inflammatory markers
Aung M, Yu Y, Ferguson K, Cantonwine D, Zeng L, McElrath T, Pennathur S, Mukherjee B, Meeker J. Prediction and associations of preterm birth and its subtypes with eicosanoid enzymatic pathways and inflammatory markers. Scientific Reports 2019, 9: 17049. PMID: 31745121, PMCID: PMC6863859, DOI: 10.1038/s41598-019-53448-z.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthMultiple logistic regressionCross-sectional study of pregnant womenAssociation of preterm birthCases of preterm birthStudy of pregnant womenOverall preterm birthPreterm birth casesPreterm birth outcomesCytochrome P450 metabolitesLogistic regressionOxidative stress markersAberrant placentationCross-sectional studyDelivered termCytochrome P450 productPredictive biomarkersPregnant womenPretermEicosanoid metabolitesImmune biomarkersLipoxygenase metabolitesBirth casesResolvin D1