2019
High plasma concentrations of organic pollutants negatively impact survival in amyotrophic lateral sclerosis
Goutman S, Boss J, Patterson A, Mukherjee B, Batterman S, Feldman E. High plasma concentrations of organic pollutants negatively impact survival in amyotrophic lateral sclerosis. Journal Of Neurology Neurosurgery & Psychiatry 2019, 90: 907. PMID: 30760645, PMCID: PMC6625908, DOI: 10.1136/jnnp-2018-319785.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisEnvironmental ExposureEnvironmental PollutantsFemaleHalogenated Diphenyl EthersHumansMaleMiddle AgedPolychlorinated BiphenylsSurvivalConceptsPersistent organic pollutantsPolychlorinated biphenylsHigh concentrations of persistent organic pollutantsAmyotrophic lateral sclerosisConcentrations of persistent organic pollutantsEffects of persistent organic pollutantsMeasurement of persistent organic pollutantsHazard rate of mortalitySymptom onset to diagnosisMedian diagnostic ageNegatively impacts survivalLowest quartileIndependent of ageOrganic pollutantsSummary measuresMedian timeClinical featuresMedical recordsRate of mortalityDiagnostic ageEnvironmental exposuresBulbar onsetALS diseaseCervical onsetPlasma concentrations
2013
Associations between brominated flame retardants in house dust and hormone levels in men
Johnson P, Stapleton H, Mukherjee B, Hauser R, Meeker J. Associations between brominated flame retardants in house dust and hormone levels in men. The Science Of The Total Environment 2013, 445: 177-184. PMID: 23333513, PMCID: PMC3572297, DOI: 10.1016/j.scitotenv.2012.12.017.Peer-Reviewed Original ResearchConceptsBrominated flame retardantsSex hormone binding globulinIndoor dustHouse dustThyroid-stimulating hormoneExposure to contaminantsFollicle stimulating hormoneFlame retardantsBody mass indexHouse dust concentrationsFlame retardant concentrationUS infertility clinicHormone levelsPBDE congenersLuteinizing hormoneStimulating hormoneEndocrine disruptionAssociated with total T3Inverse associationCommercial mixtureDecaBDE concentrationsReproductive effectsSerum free T4Increased free androgen indexFree androgen index