2023
Adverse birth outcomes are associated with circulating matrix metalloproteinases among pregnant women in Puerto Rico
Kim C, Cathey A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Adverse birth outcomes are associated with circulating matrix metalloproteinases among pregnant women in Puerto Rico. Journal Of Reproductive Immunology 2023, 159: 103991. PMID: 37454540, PMCID: PMC10726844, DOI: 10.1016/j.jri.2023.103991.Peer-Reviewed Original ResearchConceptsBirth outcomesMatrix metalloproteinasesFetal sexPregnant womenFemale fetusesNewborn lengthVisit 3Associated with increased odds of preeclampsiaVisit 1Impact of matrix metalloproteinasesCustomized Luminex assayGestational diabetes mellitusOdds of preeclampsiaAdverse birth outcomesAssociated with increased oddsGestational ageHealthy pregnancyMale fetusesUterine remodelingLuminex assayLogistic regression modelsDiabetes mellitusStudy visitsInverse associationExtracellular matrix
2022
Maternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico
Ashrap P, Aung M, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico. Journal Of Exposure Science & Environmental Epidemiology 2022, 32: 384-391. PMID: 35075242, PMCID: PMC9124693, DOI: 10.1038/s41370-022-00410-3.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolitesPhthalate metabolitesPlasmenyl-phosphatidylcholinesPregnant womenPuerto Rico PROTECT cohortPhthalate exposureLipidomic profilesMaternal urinary phthalate metabolitesWeeks of pregnancyMetabolite biomarkersMetabolites of di-2-ethylhexyl phthalateChild health outcomesCirculating lipid concentrationsLipidomic markersShotgun lipidomicsFatty acid chainsLipidomic signaturePROTECT cohortLipid profileCell-to-cell signalingImpactThis studyPregnancyAcid chainsPlasma samplesHealth outcomesMaternal Metals/Metalloid Blood Levels Are Associated With Lipidomic Profiles Among Pregnant Women in Puerto Rico
Kim C, Ashrap P, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal Metals/Metalloid Blood Levels Are Associated With Lipidomic Profiles Among Pregnant Women in Puerto Rico. Frontiers In Public Health 2022, 9: 754706. PMID: 35096734, PMCID: PMC8790322, DOI: 10.3389/fpubh.2021.754706.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansLipidomicsLipidsManganeseMetalloidsMetals, HeavyPregnancyPregnancy ComplicationsPregnant WomenPuerto RicoZincConceptsAdverse birth outcomesBlood levelsPlasmenyl-phosphatidylcholinesLipidomic profilesBirth outcomesPlasmenyl phosphatidylethanolamineWeeks of pregnancyPlasma lipidomic profilesMultiple comparisonsLipid sub-classesHeavy metal exposurePolyunsaturated fatty acidsPregnant womenShotgun lipidomicsMetal exposureImportant signaling pathwaysAssessed associationsBiomarker profilesAssociated with lipidEarly detectionBirth cohortDiagnostic toolExposure to manganeseSignaling pathwayFalse discovery rate
2021
Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico
Cathey A, Eaton J, Ashrap P, Watkins D, Rosario Z, Vega C, Alshawabkeh A, Cordero J, Mukherjee B, Meeker J. Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico. Environment International 2021, 154: 106565. PMID: 33882432, PMCID: PMC9923976, DOI: 10.1016/j.envint.2021.106565.Peer-Reviewed Original ResearchMeSH KeywordsBayes TheoremBiomarkersFemaleHumansOxidative StressPhthalic AcidsPregnancyPregnant WomenPuerto RicoConceptsBayesian kernel machine regressionPhthalate metabolitesEnvironmental risk scoreBiomarkers of oxidative stressPregnant womenPhthalate mixtureBayesian kernel machine regression analysisEffects of phthalate metabolitesOxidative stressIndividual phthalate metabolitesLipid oxidative stressUrinary biomarker measurementsKernel machine regressionAdverse birth outcomesPuerto Rico TestsiteOxidative stress biomarkersChemical fractionationContamination threatLongitudinal birth cohortPhthalate compoundsLinear mixed effects modelsBirth outcomesOxidative stress mechanismsStudy visitsPhthalate exposurePsychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes
Ashrap P, Aker A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Psychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes. Environment International 2021, 149: 106418. PMID: 33548848, PMCID: PMC7897320, DOI: 10.1016/j.envint.2021.106418.Peer-Reviewed Original ResearchConceptsAdverse birth outcomesPsychosocial statusBirth outcomesBody mass indexPsychosocial stressPreterm birthOdds ratioAssociated with adverse birth outcomesPre-pregnancy body mass indexSecond-hand smoke exposurePrenatal psychosocial stressPregnant womenBlood metalsClusters of womenEffects of psychosocial stressPuerto Rico TestsiteIncreased odds ratioSocial supportPerceived stressMaternal educationAdverse associationOverall preterm birthLow birth weightSpontaneous preterm birthCohort study
2018
Risk Factors During Pregnancy and Early Childhood in Rural West Bengal, India: A Feasibility Study Implemented via Trained Community Health Workers Using Mobile Data Collection Devices
Wagner A, Xia L, Pandey P, Datta S, Chattopadhyay S, Mazumder T, Santra S, Nandi U, Pal J, Joshi S, Mukherjee B. Risk Factors During Pregnancy and Early Childhood in Rural West Bengal, India: A Feasibility Study Implemented via Trained Community Health Workers Using Mobile Data Collection Devices. Maternal And Child Health Journal 2018, 22: 1286-1296. PMID: 29500782, DOI: 10.1007/s10995-018-2509-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultChildChild, PreschoolCommunity Health WorkersCross-Sectional StudiesFeasibility StudiesFemaleHealth Knowledge, Attitudes, PracticeHealth Services AccessibilityHumansIndiaInfantPregnancyPregnant WomenReferral and ConsultationRural Health ServicesRural PopulationSmartphoneYoung AdultConceptsCommunity health workersHealth workersFeasibility of community health workersRisk factorsPregnant womenTrained community health workersPrevalence of risk factorsRural communitiesHealth care servicesCross-sectional studyCare servicesBlood pressureAbnormal blood pressureAnthropometric measurementsYoung childrenAbnormal anthropometric measurementsVulnerable populationsRural West BengalStudy implementationHealth concernLower scoresStages QuestionnaireLower blood pressureWomenHealth
2014
Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth
Ferguson K, McElrath T, Ko Y, Mukherjee B, Meeker J. Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth. Environment International 2014, 70: 118-124. PMID: 24934852, PMCID: PMC4104181, DOI: 10.1016/j.envint.2014.05.016.Peer-Reviewed Original ResearchConceptsAdjusted odds ratiosUrinary phthalate metabolite levelsPreterm birthPhthalate metabolite levelsOdds ratioOdds of preterm birthAssociated with increased odds of preterm birthIncreased risk of delivering pretermCases of preterm birthWeeks of completed gestationRisk of delivering pretermAssociated with increased oddsMetabolite levelsPresentation of preeclampsiaSignificant public health problemSpontaneous preterm birthIntrauterine growth restrictionLongitudinal birth cohortPhthalate metabolite concentrationsPublic health problemBirth outcomesBirth cohortGrowth restrictionThird trimesterPregnant women
2013
Urinary phthalate metabolite concentrations among pregnant women in Northern Puerto Rico: Distribution, temporal variability, and predictors
Cantonwine D, Cordero J, Rivera-González L, Del Toro L, Ferguson K, Mukherjee B, Calafat A, Crespo N, Jiménez-Vélez B, Padilla I, Alshawabkeh A, Meeker J. Urinary phthalate metabolite concentrations among pregnant women in Northern Puerto Rico: Distribution, temporal variability, and predictors. Environment International 2013, 62: 1-11. PMID: 24161445, PMCID: PMC3874859, DOI: 10.1016/j.envint.2013.09.014.Peer-Reviewed Original ResearchConceptsMono-3-carboxypropyl phthalateMono-ethyl phthalateUrinary phthalate metabolite concentrationsMono-carboxyisooctyl phthalatePhthalate metabolite concentrationsPregnant womenMono-carboxyisononyl phthalatePhthalate metabolitesMono-2-ethylhexyl phthalatePhthalate biomarkersDetectable concentrations of phthalate metabolitesMono-2-ethyl-5-oxohexyl phthalateMetabolite concentrationsMono-2-ethyl-5-carboxypentyl phthalateConcentrations of phthalate metabolitesMono-2-ethyl-5-carboxypentylUrinary phthalate biomarkersMono-2-ethyl-5-hydroxyhexyl phthalateWomen of reproductive ageUrine samplesAssociated with phthalate exposureMono-isobutyl phthalateMono-n-butyl phthalateMono-benzyl phthalateIntraclass correlation coefficient