A Latent Variable Approach to Study Gene–Environment Interactions in the Presence of Multiple Correlated Exposures
Sánchez B, Kang S, Mukherjee B. A Latent Variable Approach to Study Gene–Environment Interactions in the Presence of Multiple Correlated Exposures. Biometrics 2011, 68: 466-476. PMID: 21955029, PMCID: PMC4405908, DOI: 10.1111/j.1541-0420.2011.01677.x.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceBiasBiometryBirth WeightCase-Control StudiesComputer SimulationEnvironmental ExposureEpidemiologic FactorsFemaleGene-Environment InteractionHumansInfant, NewbornIronLead PoisoningModels, StatisticalPregnancyPrenatal Exposure Delayed EffectsPrincipal Component AnalysisConceptsGene-environment interactionsGene-environmentEnvironmental epidemiologyCohort studyGene-environment dependenceBurden of multiple testingStudy gene-environment interactionsEnvironmental exposuresExposure dataEarly life exposuresLV frameworkG x E effectsHealth StudyCorrelated exposuresG x EDisease riskLife exposureMultiple testingFunction of environmental exposureE studyGenotype categoriesStudy of lead exposureBirth weightIron metabolism genesAdaptive trade-off