Rare‐variant association tests in longitudinal studies, with an application to the Multi‐Ethnic Study of Atherosclerosis (MESA)
He Z, Lee S, Zhang M, Smith J, Guo X, Palmas W, Kardia S, Ionita‐Laza I, Mukherjee B. Rare‐variant association tests in longitudinal studies, with an application to the Multi‐Ethnic Study of Atherosclerosis (MESA). Genetic Epidemiology 2017, 41: 801-810. PMID: 29076270, PMCID: PMC5696115, DOI: 10.1002/gepi.22081.Peer-Reviewed Original ResearchConceptsMulti-Ethnic Study of AtherosclerosisMulti-Ethnic StudyStudy of AtherosclerosisType I error rateRare-variant association testsRare variantsGene-based association testsRare-variant associationsAssociation TestLongitudinal outcomesLongitudinal studyExome sequencing dataMeasurement of blood pressureGenomic regionsSequence dataTrait heritabilitySequencing studiesMeasured outcomesGenetic variantsVariant analysisModerate sample sizesIndividual variantsRobust to misspecificationWithin-subject correlationStatistical powerCurrent Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases
McAllister K, Mechanic L, Amos C, Aschard H, Blair I, Chatterjee N, Conti D, Gauderman W, Hsu L, Hutter C, Jankowska M, Kerr J, Kraft P, Montgomery S, Mukherjee B, Papanicolaou G, Patel C, Ritchie M, Ritz B, Thomas D, Wei P, Witte J, participants O. Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases. American Journal Of Epidemiology 2017, 186: 753-761. PMID: 28978193, PMCID: PMC5860428, DOI: 10.1093/aje/kwx227.Peer-Reviewed Original ResearchConceptsGene-environment interaction studiesStudies of complex diseasesGene-environmentAmerican Society of Human Genetics meetingMeasures of environmental exposureGene-environment interactionsComplex diseasesNational Institute of Environmental Health SciencesNational Cancer InstituteEnvironmental Health SciencesStudy designHealth SciencesCancer InstituteEnvironmental exposuresEnvironmental exposure assessmentNational InstituteLarge-scale studiesExposure assessmentNext-generation sequencing dataDisease outcomeNationalSequence dataThemesStudies of human populationsParticipants