Investigating parent of origin effects (POE) and anticipation in Irish Lynch Syndrome kindreds.
Farrell M, Hughes D, Schmid J, Boonstra P, Mukherjee B, Walshe M, Mac Mathuna P, Gallagher D. Investigating parent of origin effects (POE) and anticipation in Irish Lynch Syndrome kindreds. Journal Of Clinical Oncology 2012, 30: e12031-e12031. DOI: 10.1200/jco.2012.30.15_suppl.e12031.Peer-Reviewed Original ResearchAffected parent-child pairsParent-of-origin effectsParent-child pairsInvestigate parent-of-origin effectsLynch syndrome familiesGermline MMR mutationsLynch syndrome kindredT-testMMR mutationsPaired t-testRisk of diseaseSyndrome familiesInvestigate parentGenetic anticipationParental ageP-valueGroup comparisonsDisease allelesOffspring ageAgeDynamic mutationSeverity of diseaseKindredIncreasing severityFamily