2018
Subset-Based Analysis Using Gene-Environment Interactions for Discovery of Genetic Associations across Multiple Studies or Phenotypes
Yu Y, Xia L, Lee S, Zhou X, Stringham H, Boehnke M, Mukherjee B. Subset-Based Analysis Using Gene-Environment Interactions for Discovery of Genetic Associations across Multiple Studies or Phenotypes. Human Heredity 2018, 83: 283-314. PMID: 31132756, PMCID: PMC7034441, DOI: 10.1159/000496867.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesCholesterolCohort StudiesComputer SimulationC-Reactive ProteinFinlandGene FrequencyGene-Environment InteractionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLipoproteins, LDLMeta-Analysis as TopicModels, GeneticPhenotypePolymorphism, Single NucleotideConceptsPresence of G-E interactionsGenetic associationHeterogeneity of genetic effectsDiscovery of genetic associationsGene-environment (G-EMarginal genetic effectsG-E interactionsGenome-wide association studiesGene-environment interactionsGenetic effectsData examplesSimulation studySingle nucleotide polymorphismsGene-environmentAssociation studiesAssociation analysisScreening toolMarginal associationNucleotide polymorphismsPresence of heterogeneityAssociationEnvironmental factorsIncreased powerMultiple studiesG-E
2014
Testing departure from additivity in Tukey's model using shrinkage: application to a longitudinal setting
Ko Y, Mukherjee B, Smith J, Park S, Kardia S, Allison M, Vokonas P, Chen J, Diez‐Roux A. Testing departure from additivity in Tukey's model using shrinkage: application to a longitudinal setting. Statistics In Medicine 2014, 33: 5177-5191. PMID: 25112650, PMCID: PMC4227925, DOI: 10.1002/sim.6281.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingAtherosclerosisBone and BonesComputer SimulationEnvironmental ExposureEthnicityFemaleGene-Environment InteractionHumansIronLeadLeast-Squares AnalysisLikelihood FunctionsLongitudinal StudiesMaleMiddle AgedModels, GeneticUnited StatesUnited States Department of Veterans AffairsConceptsGene-environment interactionsMulti-Ethnic Study of AtherosclerosisModel of gene-environment interactionMulti-Ethnic StudyTukey's modelLongitudinal settingStudy of AtherosclerosisNormative Aging StudyCase-control studyIncreasing categoriesAging StudyTested interactionsLongitudinal studyCategorical variablesRobust to misspecificationInteraction termsTest departuresShrinkage estimatorsWald testInteraction estimatesIncreased powerOne-degree-of-freedom modelInteraction effectsSetsEnvironmental markers