2024
The mediating role of systemic inflammation and moderating role of racialization in disparities in incident dementia
Higgins Tejera C, Ware E, Hicken M, Kobayashi L, Wang H, Blostein F, Zawistowski M, Mukherjee B, Bakulski K. The mediating role of systemic inflammation and moderating role of racialization in disparities in incident dementia. Communications Medicine 2024, 4: 142. PMID: 39003383, PMCID: PMC11246521, DOI: 10.1038/s43856-024-00569-w.Peer-Reviewed Original ResearchIncident dementiaRacial disparitiesRisk of incident dementiaCumulative incidence of dementiaNon-Hispanic white participantsIncidence of dementiaControlled direct effectExposure to racismDementia incidenceDementia burdenUS HealthC-reactive proteinWhite participantsLower C-reactive proteinHigh C-reactive proteinDementiaHigher CRP levelsCognitive testsDisparitiesSystemic racismGroup membershipFollow-upParticipantsModerate portionGroup status
2021
Perfluoroalkyl and polyfluoroalkyl substances and body size and composition trajectories in midlife women: the study of women’s health across the nation 1999–2018
Ding N, Karvonen-Gutierrez C, Herman W, Calafat A, Mukherjee B, Park S. Perfluoroalkyl and polyfluoroalkyl substances and body size and composition trajectories in midlife women: the study of women’s health across the nation 1999–2018. International Journal Of Obesity 2021, 45: 1937-1948. PMID: 33986457, PMCID: PMC8384652, DOI: 10.1038/s41366-021-00848-9.Peer-Reviewed Original ResearchConceptsWaist circumferenceMidlife womenFat massLowest tertileAssociated with greater body sizeStudy of women's healthResultsAfter multivariable adjustmentAssociated with accelerated increaseTrajectories of weightAssociated with weightSubjects/MethodsThis studyWomen's HealthObesity riskFollow-upDual-energy X-ray absorptiometryLinear mixed modelsHighest tertileX-ray absorptiometryGreater body sizeMultivariable adjustmentBody fatEpidemiological evidenceNo significant resultsBody compositionAverage follow-up
2019
A comprehensive gene–environment interaction analysis in Ovarian Cancer using genome‐wide significant common variants
Kim S, Wang M, Tyrer J, Jensen A, Wiensch A, Liu G, Lee A, Ness R, Salvatore M, Tworoger S, Whittemore A, Anton‐Culver H, Sieh W, Olson S, Berchuck A, Goode E, Goodman M, Doherty J, Chenevix‐Trench G, Rossing M, Webb P, Giles G, Terry K, Ziogas A, Fortner R, Menon U, Gayther S, Wu A, Song H, Brooks‐Wilson A, Bandera E, Cook L, Cramer D, Milne R, Winham S, Kjaer S, Modugno F, Thompson P, Chang‐Claude J, Harris H, Schildkraut J, Le N, Wentzensen N, Trabert B, Høgdall E, Huntsman D, Pike M, Pharoah P, Pearce C, Mukherjee B. A comprehensive gene–environment interaction analysis in Ovarian Cancer using genome‐wide significant common variants. International Journal Of Cancer 2019, 144: 2192-2205. PMID: 30499236, PMCID: PMC6399057, DOI: 10.1002/ijc.32029.Peer-Reviewed Original ResearchConceptsOral contraceptive pill useExcess risk due to additive interactionOvarian cancer risk factorsOral contraceptive pillsGene-environment interaction analysisCancer risk factorsGene-environment analysisOvarian cancer casesOCP useCase-control studyGenome-wide association analysisAdditive scaleCancer casesOvarian cancerOdds ratioCommon variantsDuration of OCP useRisk allelesRisk factorsGenetic variantsAdditive interactionAssociation analysisWomenFollow-upC allele
2018
Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study
Wang W, Moroi S, Bakulski K, Mukherjee B, Weisskopf M, Schaumberg D, Sparrow D, Vokonas P, Hu H, Park S. Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study. Environmental Health Perspectives 2018, 126: 087002. PMID: 30102601, PMCID: PMC6108844, DOI: 10.1289/ehp3442.Peer-Reviewed Original ResearchConceptsPrimary open-angle glaucomaIncident primary open-angle glaucomaRisk of primary open-angle glaucomaOpen-angle glaucomaHazard ratioIncident cases of POAGCases of primary open-angle glaucomaAsymmetric cup-to-disc ratioFollow-upPrimary open-angle glaucoma casesEtiology of primary open-angle glaucomaCup-to-disc ratioVisual field defectsCox proportional hazards regressionAssociated with hazard ratiosProportional hazards regressionOxidative stressEstimate hazard ratiosDisc hemorrhageOcular evaluationPatella leadField defectsCumulative lead doseProspective cohortSurvival curves
2017
Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies
Patel C, Kerr J, Thomas D, Mukherjee B, Ritz B, Chatterjee N, Jankowska M, Madan J, Karagas M, McAllister K, Mechanic L, Fallin M, Ladd-Acosta C, Blair I, Teitelbaum S, Amos C. Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies. Cancer Epidemiology Biomarkers & Prevention 2017, 26: 1370-1380. PMID: 28710076, PMCID: PMC5581729, DOI: 10.1158/1055-9965.epi-17-0459.Peer-Reviewed Original ResearchConceptsFollow-up of study participantsInfluence cancer riskExposure and behaviourPopulation-based studyExposure assessmentCase-control studyPhysical activityCancer riskCorrelated exposuresStudy participantsEpidemiological studiesGenetic susceptibilityEnvironmental exposure assessmentFollow-upData collectionMultidimensional indicatorsCancer developmentEvaluated 1Indicators of exposureComplex effects of environmental factorsEpidemiological investigationsOccupational exposure assessmentAssessmentEnvironmental factorsDisease development