2022
The construction of cross-population polygenic risk scores using transfer learning
Zhao Z, Fritsche L, Smith J, Mukherjee B, Lee S. The construction of cross-population polygenic risk scores using transfer learning. American Journal Of Human Genetics 2022, 109: 1998-2008. PMID: 36240765, PMCID: PMC9674947, DOI: 10.1016/j.ajhg.2022.09.010.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesPolygenic risk scoresAncestry groupsTransferability of PRSPRS-CSPolygenic risk score methodsEuropean ancestry cohortsIndividuals of African ancestryIndividuals of South Asian ancestryNon-European ancestry groupsNon-European ancestrySouth Asian ancestryAssociation studiesDichotomous traitsSouth Asian sampleEuropean ancestryGenetic researchPRS modelAncestryAsian ancestryAfrican ancestryAfrican samplesUK BiobankRisk scoreAsian samples
2021
On cross-ancestry cancer polygenic risk scores
Fritsche L, Ma Y, Zhang D, Salvatore M, Lee S, Zhou X, Mukherjee B. On cross-ancestry cancer polygenic risk scores. PLOS Genetics 2021, 17: e1009670. PMID: 34529658, PMCID: PMC8445431, DOI: 10.1371/journal.pgen.1009670.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresGenome-wide association studiesProstate cancer polygenic risk scoresPolygenic risk score distributionRecruitment of diverse participantsAncestry groupsPolygenic risk score methodsRisk scoreNon-genetic risk factorsElectronic health recordsBreast cancer casesHealth recordsUK BiobankGWAS effortsDisease risk assessmentCancer casesAssociation studiesGenetic dataEuropean ancestryPersonalized risk stratificationSummary statisticsRisk factorsAncestryDiverse participantsField of cancer
2017
Explaining Disparities in Ovarian Cancer Incidence Rates between Women of African and European Ancestry: The Role of Genetic Factors
Mullins M, Mukherjee B, Wu A, Pike M, Pharoah P, Berchuck A, Pearce C. Explaining Disparities in Ovarian Cancer Incidence Rates between Women of African and European Ancestry: The Role of Genetic Factors. Cancer Epidemiology Biomarkers & Prevention 2017, 26: 433-434. DOI: 10.1158/1055-9965.epi-17-0030.Peer-Reviewed Original ResearchGenetic risk scoreOvarian cancer incidence ratesNon-Hispanic White (NHWPopulation attributable risk percentCollaborative Oncological Gene-environment StudyCancer incidence ratesNon-genetic risk factorsIncidence rateAfrican AmericansAssociated with ovarian cancer riskOvarian Cancer Association ConsortiumOophorectomy ratesRisk of ovarian cancerAncestry groupsOvarian cancer riskAttributable risk percentNon-genetic riskGene-environment studiesOvarian cancerSingle nucleotide polymorphismsRisk factorsConditional logistic regressionGRS quintileRisk percentLowest quintile