Body mass index associates with amyotrophic lateral sclerosis survival and metabolomic profiles
Goutman S, Boss J, Iyer G, Habra H, Savelieff M, Karnovsky A, Mukherjee B, Feldman E. Body mass index associates with amyotrophic lateral sclerosis survival and metabolomic profiles. Muscle & Nerve 2022, 67: 208-216. PMID: 36321729, PMCID: PMC9957813, DOI: 10.1002/mus.27744.Peer-Reviewed Original ResearchConceptsBody mass indexBody mass index trajectoriesMetabolomic profilesAmyotrophic lateral sclerosis survivalAmyotrophic lateral sclerosisAmyotrophic lateral sclerosis participantsMass indexBody mass index lossBody mass index trajectory groupsSelf-reported body heightParticipants lost weightShorter survivalProspective cohortSurvival associationsStudy entryMetabolomic networksGeneralized estimating equationsSymptom onsetBMI trendsWeight lossSurvivalBile acidsBody heightTrajectory groupsPotential mechanismsOccupational history associates with ALS survival and onset segment
Goutman S, Boss J, Godwin C, Mukherjee B, Feldman E, Batterman S. Occupational history associates with ALS survival and onset segment. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2022, 24: 219-229. PMID: 36193557, PMCID: PMC10067530, DOI: 10.1080/21678421.2022.2127324.Peer-Reviewed Original ResearchConceptsStandard Occupational ClassificationOccupational settingsOnset segmentSelf-reported occupational exposureAmyotrophic Lateral Sclerosis RegistrySelf-reported exposureExposure to particulate matterCervical onsetStandard Occupational Classification codesMultinomial logistic regression modelCox proportional hazards modelsLogistic regression modelsSymptom onset to diagnosisOccupational pesticide exposureProportional hazards modelAssociated with workMaintenance occupationsGrounds cleaningALS clinicALS participantsProspective cohortAdjusted modelsDiagnosis ageAmyotrophic lateral sclerosis participantsOccupational history