2019
Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons
Desban L, Prendergast A, Roussel J, Rosello M, Geny D, Wyart C, Bardet PL. Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons. PLOS Biology 2019, 17: e3000235. PMID: 31002663, PMCID: PMC6493769, DOI: 10.1371/journal.pbio.3000235.Peer-Reviewed Original ResearchConceptsRing of actinApical junctional complexApical extensionSensory cellsApical actin ringSensory cell typesInner ear sensory cellsTime-lapse imagingVivo time-lapse imagingZebrafish embryosMorphogenesisActin ringsCell typesHair bundlesMechanosensory responsesProtrusion elongationJunctional complexesActinTail bendingMolecular factorsCerebrospinal fluid-contacting neuronsApical attachmentCritical roleOsmolarity changesApical processes
2017
The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes
Djenoune L, Desban L, Gomez J, Sternberg JR, Prendergast A, Langui D, Quan FB, Marnas H, Auer TO, Rio JP, Del Bene F, Bardet PL, Wyart C. The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes. Scientific Reports 2017, 7: 719. PMID: 28389647, PMCID: PMC5428266, DOI: 10.1038/s41598-017-00350-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedAxonsBiomarkersCarrier ProteinsCell DifferentiationCerebrospinal FluidFluorescent Antibody TechniqueGanglia, SpinalHomozygoteMutationNeuronsSensory Receptor CellsSignal TransductionSpinal CordSpinal Nerve RootsTRPP Cation ChannelsZebrafishZebrafish ProteinsConceptsDual developmental originDevelopmental originsDistinct progenitor domainsApical extensionDistinct functional subtypesDifferent developmental originsCerebrospinal fluid-contacting neuronsTranscription factorsMechanical cuesZebrafish larvaeDistinct functionsProgenitor domainsCentral nervous systemCell typesDistinct cascadesFunctional populationsDifferent functional propertiesCSF-cNsNovel avenuesPKD2L1 channelFunctional subtypesSensory neuronsNeuronal targetsDistinct functional populationsSpecific markers
2012
The metalloproteinase inhibitor Reck is essential for zebrafish DRG development
Prendergast A, Linbo TH, Swarts T, Ungos JM, McGraw HF, Krispin S, Weinstein BM, Raible DW. The metalloproteinase inhibitor Reck is essential for zebrafish DRG development. Development 2012, 139: 1141-1152. PMID: 22296847, PMCID: PMC3283124, DOI: 10.1242/dev.072439.Peer-Reviewed Original ResearchConceptsRECK functionsNeural crestForward genetic screenCell fate specificationMultipotent cell lineagesCell-autonomous fashionCysteine-rich proteinNeural crest cellsSensory neuron formationReversion-inducing cysteine-rich proteinGenetic screenInhibitors of metalloproteinasesFate specificationSensory neuron precursorsCell motilityCrest cellsCell lineagesProper migrationDRG formationDRG developmentNeuron formationMyriad tissuesKazal motifsNeuron precursorsGenes