2013
Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction
Gamo NJ, Duque A, Paspalas CD, Kata A, Fine R, Boven L, Bryan C, Lo T, Anighoro K, Bermudez L, Peng K, Annor A, Raja A, Mansson E, Taylor SR, Patel K, Simen AA, Arnsten AF. Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction. Translational Psychiatry 2013, 3: e328-e328. PMID: 24301646, PMCID: PMC4030323, DOI: 10.1038/tp.2013.104.Peer-Reviewed Original ResearchConceptsPrefrontal cortexCyclic adenosine monophosphateMental illnessRestraint stressCognitive dysfunctionControl groupStress-induced cognitive dysfunctionPhosphodiesterase 4Schizophrenia 1Prefrontal cognitive dysfunctionMild restraint stressH restraint stressUnoperated control groupKD ratsDISC1 mutationViral knockdownNormal animalsPFC dysfunctionImpair functionIncreases SusceptibilityDysfunctionDISC1 geneIllnessCAMP levelsMultifunctional scaffolding protein
2007
α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex
Wang M, Ramos BP, Paspalas CD, Shu Y, Simen A, Duque A, Vijayraghavan S, Brennan A, Dudley A, Nou E, Mazer JA, McCormick DA, Arnsten AF. α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex. Cell 2007, 129: 397-410. PMID: 17448997, DOI: 10.1016/j.cell.2007.03.015.Peer-Reviewed Original ResearchConceptsHCN channel blockadePrefrontal cortical neuronsDelay-related firingΑ2A adrenoceptorsChannel blockadeCortical neuronsInhibition of cAMPAlpha2A adrenoceptorsDendritic spinesNetwork firingElectrophysiological studiesPFC neuronsRecurrent excitationFunctional connectivityHCN channelsPrefrontal cortexHCN1 channelsPFC networksCAMP inhibitionStimulationBlockade