Alexandra Kimmel
About
Research
Publications
2021
Blood Pressure Trajectory Groups and Outcome After Endovascular Thrombectomy: A Multicenter Study
Petersen NH, Kodali S, Meng C, Li F, Nguyen CK, Peshwe KU, Strander S, Silverman A, Kimmel A, Wang A, Anadani M, Almallouhi E, Spiotta AM, Kim JT, Giles JA, Keyrouz SG, Farooqui M, Zevallos C, Maier IL, Psychogios MN, Liman J, Riou-Comte N, Richard S, Gory B, Wolfe S, Brown PA, Fargen KM, Mistry EA, Fakhri H, Mistry AM, Wong KH, de Havenon A, Nascimento FA, Kan P, Matouk C, Ortega-Gutiérrez S, Sheth KN. Blood Pressure Trajectory Groups and Outcome After Endovascular Thrombectomy: A Multicenter Study. Stroke 2021, 53: 1216-1225. PMID: 34781705, PMCID: PMC8960326, DOI: 10.1161/strokeaha.121.034408.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial hemorrhageEndovascular thrombectomyBlood pressure trajectoriesFunctional outcomeHemorrhagic transformationIschemic strokeSBP trajectoriesIntracranial hemorrhageAnterior circulation large vessel occlusion ischemic strokeModified Rankin Scale (mRS) 90 daysTrajectory groupsLarge vessel occlusion ischemic strokeMulticenter retrospective cohort studySystolic blood pressure trajectoriesBlood pressure courseOptimal hemodynamic managementSBP trajectory groupsRetrospective cohort studyAcute ischemic strokeElevated blood pressurePoor functional outcomePressure trajectoriesBlood pressure dataCohort studySecondary outcomesAssociation of Pediatric ASPECTS and NIH Stroke Scale, Hemorrhagic Transformation, and 12-Month Outcome in Children With Acute Ischemic Stroke
Beslow L, Vossough A, Ichord R, Slavova N, Yau M, Gajera J, Stojanovski B, Adil M, Breimann J, Kimmel A, Mackay M. Association of Pediatric ASPECTS and NIH Stroke Scale, Hemorrhagic Transformation, and 12-Month Outcome in Children With Acute Ischemic Stroke. Neurology 2021, 97: e1202-e1209. PMID: 34389646, DOI: 10.1212/wnl.0000000000012558.Peer-Reviewed Original ResearchAcute arterial ischemic strokeHemorrhagic transformationIschemic strokeFunctional outcomePedNIHSS scoreStroke severityAlberta Stroke Program Early CT ScoreAcute supratentorial ischemic strokeNIH Stroke Scale scoreRoyal Children's Hospital MelbournePediatric Stroke Outcome MeasureAcute revascularization therapyClinical stroke severitySymptomatic intracranial hemorrhageArterial ischemic strokeClass II evidenceStroke risk factorsStroke Scale scoreAcute ischemic strokeSupratentorial ischemic strokeNIH Stroke ScaleFuture pediatric studiesStroke Outcome MeasureYears of agePresence of tumorEndovascular and thrombolytic treatment eligibility in childhood arterial ischemic stroke
Hutchinson M, Beslow L, Shih E, Licht D, Kimmel A, Granath C, Ichord R. Endovascular and thrombolytic treatment eligibility in childhood arterial ischemic stroke. European Journal Of Paediatric Neurology 2021, 34: 99-104. PMID: 34454335, DOI: 10.1016/j.ejpn.2021.08.004.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeLarge vessel occlusionEndovascular therapyHyperacute therapyIV-tPAVessel occlusionIschemic strokeMedical contraindicationsScore 6Childhood arterial ischemic strokeIntravenous tissue plasminogen activatorNIH Stroke Scale scoreArterial ischemic strokeStroke Scale scoreSingle-center cohortMild neurologic deficitsTime of presentationComplete vessel occlusionTissue plasminogen activatorChildren ages 2Hyperacute treatmentClinical characteristicsNeurologic deficitsStroke pathwayTreatment eligibility
2020
Direct carotid puncture for mechanical thrombectomy in acute ischemic stroke patients with prohibitive vascular access.
Cord BJ, Kodali S, Strander S, Silverman A, Wang A, Chouairi F, Koo AB, Nguyen CK, Peshwe K, Kimmel A, Porto CM, Hebert RM, Falcone GJ, Sheth KN, Sansing LH, Schindler JL, Matouk CC, Petersen NH. Direct carotid puncture for mechanical thrombectomy in acute ischemic stroke patients with prohibitive vascular access. Journal Of Neurosurgery 2020, 135: 53-63. PMID: 32796146, PMCID: PMC9491727, DOI: 10.3171/2020.5.jns192737.Peer-Reviewed Original ResearchDirect carotid punctureSmaller infarct volumesMechanical thrombectomyVascular accessFunctional outcomeAIS-LVONIHSS scoreDCP groupInfarct volumeTransfemoral accessNeck hematomaStroke patientsCarotid punctureABMT groupAnterior circulation acute ischemic strokeCommon carotid artery dissectionAcute ischemic stroke patientsDirect carotid accessEmergency mechanical thrombectomyAcute ischemic strokeAdmission NIHSS scoreCarotid artery dissectionIschemic stroke patientsGood functional outcomeLarge vessel occlusionBlood Pressure Decreases Occur Throughout Endovascular Thrombectomy and Are Associated with Poor Functional Outcome (4872)
Kimmel A, Silverman A, Kodali S, Strander S, Nguyen C, Peshwe K, Wang A, Cardenas G, Holcombe A, Zevallos C, Dandapat S, Sansing L, Schindler J, Falcone G, Matouk C, Sheth K, Ortega-Gutierrez S, Petersen N. Blood Pressure Decreases Occur Throughout Endovascular Thrombectomy and Are Associated with Poor Functional Outcome (4872). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.4872.Peer-Reviewed Original ResearchRisk of Worse Outcome in Stroke Patients with High Blood Pressure Variability After Endovascular Thrombectomy May Be Amplified by Impaired Cerebral Autoregulation (4457)
Nguyen C, Silverman A, Wang A, Kodali S, Strander S, Kimmel A, Peshwe K, de Havenon A, Gilmore E, Sansing L, Schindler J, Matouk C, Sheth K, Petersen N. Risk of Worse Outcome in Stroke Patients with High Blood Pressure Variability After Endovascular Thrombectomy May Be Amplified by Impaired Cerebral Autoregulation (4457). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.4457.Peer-Reviewed Original ResearchCerebral Autoregulation-guided Parameters for Predicting Midline Shift After Large-vessel Occlusion Ischemic Stroke (4253)
Silverman A, Wang A, Kodali S, Strander S, Kimmel A, Nguyen C, Peshwe K, Matouk C, Sheth K, Marshall R, Tan C, Petersen N. Cerebral Autoregulation-guided Parameters for Predicting Midline Shift After Large-vessel Occlusion Ischemic Stroke (4253). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.4253.Peer-Reviewed Original ResearchCharacterization of Blood Pressure Trajectories in the Hyperacute Phase of Large Vessel Occlusion Ischemic Stroke (4507)
Peshwe K, Nguyen C, Kodali S, Strander S, Kimmel A, Wang A, Matouk C, Sansing L, Sheth K, Wira C, Silverman A, Petersen N. Characterization of Blood Pressure Trajectories in the Hyperacute Phase of Large Vessel Occlusion Ischemic Stroke (4507). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.4507.Peer-Reviewed Original ResearchStandardizing treatment of preterm infants with post-hemorrhagic hydrocephalus at a single institution with a multidisciplinary team
Flanders T, Kimmel A, Lang S, Bellah R, Chuo J, Wellons J, Flibotte J, Heuer G. Standardizing treatment of preterm infants with post-hemorrhagic hydrocephalus at a single institution with a multidisciplinary team. Child's Nervous System 2020, 36: 1737-1744. PMID: 31953576, DOI: 10.1007/s00381-020-04508-7.Peer-Reviewed Original ResearchConceptsPost-hemorrhagic hydrocephalusVentricular access devicePathway implementationPatient outcomesCerebrospinal fluidMultidisciplinary teamLevel IV NICUMarked practice variationVentriculoperitoneal shunt placementNeonatal care providersQuality improvement studyLocal clinical pathwayBackgroundPreterm infantsPHH infantsVPS patientsPreterm infantsVAD placementNeonatology teamShunt placementTreatment complianceCSF diversionSingle institutionClinical pathwayPractice variationSurgical procedures
2019
Deviation from Dynamic and Personalized Optimal Blood Pressure Targets is Associated With Worse Functional Outcomes After Aneurysmal Subarachnoid Hemorrhage
Silverman A, Kodali S, Strander S, Gilmore E, Kimmel A, Wang A, Cord B, Falcone G, Hebert R, Matouk C, Sheth K, Petersen N. Deviation from Dynamic and Personalized Optimal Blood Pressure Targets is Associated With Worse Functional Outcomes After Aneurysmal Subarachnoid Hemorrhage. Neurosurgery 2019, 66: 310-186. DOI: 10.1093/neuros/nyz310_186.Peer-Reviewed Original Research