2022
Alterations in high‐dimensional T‐cell profile and gene signature of immune aging in HIV‐infected older adults without viremia
Shin MS, Park H, Salahuddin S, Montgomery RR, Emu B, Shaw AC, Kang I. Alterations in high‐dimensional T‐cell profile and gene signature of immune aging in HIV‐infected older adults without viremia. Aging Cell 2022, 21: e13702. PMID: 36036630, PMCID: PMC9577958, DOI: 10.1111/acel.13702.Peer-Reviewed Original ResearchConceptsOlder human immunodeficiency virusPeripheral blood mononuclear cellsHuman immunodeficiency virusAntiretroviral therapyT cellsDetectable viremiaMemory CD8HIV infectionAge-associated immune alterationsYoung human immunodeficiency virusReplication-competent HIV-1Combination antiretroviral therapyEffector memory CD8T-cell countsSubset of CD4T cell profileBlood mononuclear cellsAgeing-associated genesEM CD8Immune alterationsMemory CD4Immune agingImmunodeficiency virusInflammatory moleculesMononuclear cells
2016
Host Resistance and Immune Aging
Bandaranayake T, Shaw AC. Host Resistance and Immune Aging. Clinics In Geriatric Medicine 2016, 32: 415-432. PMID: 27394014, PMCID: PMC6986475, DOI: 10.1016/j.cger.2016.02.007.Peer-Reviewed Original ResearchConceptsImmune systemImpaired innate immune responseToll-like receptor functionEarly pro-inflammatory responseNeutrophil extracellular trap formationT cell compartmentB cell subsetsPro-inflammatory responseExtracellular trap formationInnate immune responseInnate immune systemAdaptive immune systemHuman immune systemBasal inflammationCytomegalovirus infectionImmune agingCell subsetsImmunologic challengeImmune responseT-lineageReceptor functionOlder adultsFunction altersCell compartmentAge
2014
Aging of the human innate immune system in HIV infection
Zapata HJ, Shaw AC. Aging of the human innate immune system in HIV infection. Current Opinion In Immunology 2014, 29: 127-136. PMID: 24997358, PMCID: PMC4145838, DOI: 10.1016/j.coi.2014.06.007.Peer-Reviewed Original ResearchConceptsHIV infectionHIV-negative adultsChronic inflammatory statePro-inflammatory environmentInnate immune recognitionInnate immune responseInnate immune systemHuman innate immune systemMicrobial translocationImmune agingInflammatory stateImmune responseEndogenous ligandImmune recognitionImmune systemInfectionMultiple factorsEarly stagesHIV