2021
Antibodies against human endogenous retrovirus K102 envelope activate neutrophils in systemic lupus erythematosus
Tokuyama M, Gunn BM, Venkataraman A, Kong Y, Kang I, Rakib T, Townsend MJ, Costenbader KH, Alter G, Iwasaki A. Antibodies against human endogenous retrovirus K102 envelope activate neutrophils in systemic lupus erythematosus. Journal Of Experimental Medicine 2021, 218: e20191766. PMID: 34019642, PMCID: PMC8144942, DOI: 10.1084/jem.20191766.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusNeutrophil extracellular trapsLupus erythematosusImmune complexesFormation of NETsEnvelope proteinSLE patient bloodInnate immune activationImmune complex formationActivate neutrophilsInterferon statusAutoantibody levelsIgG levelsHigher interferonImmune activationNeutrophil phagocytosisSLE IgGNeutrophil activationExtracellular trapsSLE plasmaNeutrophil elastasePatient's bloodErythematosusNeutrophilsPhagocytosis
2012
Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes
Henault J, Martinez J, Riggs JM, Tian J, Mehta P, Clarke L, Sasai M, Latz E, Brinkmann MM, Iwasaki A, Coyle AJ, Kolbeck R, Green DR, Sanjuan MA. Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes. Immunity 2012, 37: 986-997. PMID: 23219390, PMCID: PMC3786711, DOI: 10.1016/j.immuni.2012.09.014.Peer-Reviewed Original ResearchConceptsToll-like receptor 9Adaptor protein 3Plasmacytoid dendritic cellsDNA-containing immune complexesI interferonPathogenic DNAMicrotubule-associated proteinsType I interferon secretionIFN-α productionDNA immune complexesPreinitiation complexType I interferonAnti-DNA autoantibodiesNoncanonical autophagyAutophagic pathwayHost DNADendritic cellsAutoimmune disordersReceptor 9Interferon secretionChain 3Immune complexesProtein 3DNAInterferon