2013
CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity
Kumamoto Y, Linehan M, Weinstein JS, Laidlaw BJ, Craft JE, Iwasaki A. CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity. Immunity 2013, 39: 733-743. PMID: 24076051, PMCID: PMC3819035, DOI: 10.1016/j.immuni.2013.08.029.Peer-Reviewed Original ResearchConceptsDermal dendritic cellsDendritic cellsDermal DCsTh2 cellsT cellsT helper 2 cellsT helper responsesInterleukin-4 productionExpression of CD69Th2 cell developmentDC depletionLymph nodesTh2 immunityHelper responsesSubcutaneous immunizationNippostrongylus brasiliensisKey mediatorTransient depletionCell developmentImmunityOvalbuminDepletion approachCellsParticular subsetCD301b
2008
The autophagy gene ATG5 plays an essential role in B lymphocyte development
Miller BC, Zhao Z, Stephenson LM, Cadwell K, Pua HH, Lee HK, Mizushima NN, Iwasaki A, He YW, Swat W, Virgin HW. The autophagy gene ATG5 plays an essential role in B lymphocyte development. Autophagy 2008, 4: 309-314. PMID: 18188005, DOI: 10.4161/auto.5474.Peer-Reviewed Original ResearchConceptsB cell developmentCell developmentGene ATG5Pre-B cell transitionB lymphocyte developmentDeletion of Atg5Fetal liver progenitorsAutophagy gene ATG5B cell survivalCell lineagesCell transitionLymphocyte developmentCell survivalB-1a B cellsCell deathCre-loxP technologyCytoplasmic constituentsATG5Liver progenitorsEssential roleSignificant defectsB cellsDiscrete stagesCell numberCells