2013
ELF4 is critical for induction of type I interferon and the host antiviral response
You F, Wang P, Yang L, Yang G, Zhao YO, Qian F, Walker W, Sutton R, Montgomery R, Lin R, Iwasaki A, Fikrig E. ELF4 is critical for induction of type I interferon and the host antiviral response. Nature Immunology 2013, 14: 1237-1246. PMID: 24185615, PMCID: PMC3939855, DOI: 10.1038/ni.2756.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCells, CulturedDNA-Binding ProteinsHEK293 CellsHeLa CellsHost-Pathogen InteractionsHumansImmunoblottingInterferon Regulatory Factor-3Interferon Regulatory Factor-7Interferon-betaMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMicroscopy, ConfocalProtein BindingReverse Transcriptase Polymerase Chain ReactionRNA InterferenceSignal TransductionSurvival AnalysisTranscription FactorsTranscriptional ActivationWest Nile FeverWest Nile virusConceptsType I interferonI interferonAntiviral immune responseHost antiviral responseImmune responseAntiviral responseInterferonCentral eventInduction
2011
Autophagy in the control and pathogenesis of viral infection
Yordy B, Iwasaki A. Autophagy in the control and pathogenesis of viral infection. Current Opinion In Virology 2011, 1: 196-203. PMID: 21927636, PMCID: PMC3171969, DOI: 10.1016/j.coviro.2011.05.016.Peer-Reviewed Original ResearchConceptsEukaryotic defense mechanismEukaryotic cell metabolismIntracellular pathogensVertebrate immune systemTime of starvationConstitutive autophagyCellular proteinsKey unanswered questionsCell metabolismAncient abilityAutophagyDefense mechanismsCell processesAntiviral immune responseRecent findingsPathogensCentral roleViral pathogensImmune systemOrganellesViral infectionMachineryUnanswered questionsImmune responseProtein
2010
Antiviral immune responses in the genital tract: clues for vaccines
Iwasaki A. Antiviral immune responses in the genital tract: clues for vaccines. Nature Reviews Immunology 2010, 10: 699-711. PMID: 20829886, PMCID: PMC3678359, DOI: 10.1038/nri2836.Peer-Reviewed Original ResearchConceptsGenital mucosaT cellsGenital tractHerpes simplex virus type 2Simplex virus type 2Innate immune cellsT cell populationsAntiviral immune responseFemale genital tractPattern recognition receptorsVirus type 2Immune correlatesMemory CD4Memory CD8Viral clearanceHuman papillomavirusImmune cellsMemory lymphocytesSuccessful vaccineHIV-1Immune responseSevere diseaseVaginal epitheliumAdaptive immunityTarget cell type
2008
Autophagy and antiviral immunity
Lee HK, Iwasaki A. Autophagy and antiviral immunity. Current Opinion In Immunology 2008, 20: 23-29. PMID: 18262399, PMCID: PMC2271118, DOI: 10.1016/j.coi.2008.01.001.Peer-Reviewed Original ResearchConceptsViral infectionViral replicationAdaptive antiviral immune responsesEndogenous viral antigensCD4 T cellsMHC class II loading compartmentsAntiviral immune responseCritical effector mechanismAdaptive immune systemViral antigensEffector mechanismsT cellsImmune responseAntiviral immunityImmune systemLoading compartmentCertain virusesInfectionAutophagyRecent studiesCellsAntigenImmunityCellular homeostasis
2004
Involvement of Dendritic Cell Subsets in the Induction of Oral Tolerance and Immunity
FLEETON M, CONTRACTOR N, LEON F, HE J, WETZEL D, DERMODY T, IWASAKI A, KELSALL B. Involvement of Dendritic Cell Subsets in the Induction of Oral Tolerance and Immunity. Annals Of The New York Academy Of Sciences 2004, 1029: 60-65. PMID: 15681744, DOI: 10.1196/annals.1309.008.Peer-Reviewed Original ResearchConceptsSubepithelial dome regionDendritic cellsApoptotic epithelial cellsDC maturationEpithelial cellsOral administrationT cellsImmune responsePP follicle-associated epitheliumSystemic antiviral immune responsesDendritic cell subsetsPlasmacytoid dendritic cellsCross-present antigensRegulatory T cellsInduction of immunityB cell responsesAntiviral immune responseActive viral infectionFollicle-associated epitheliumMurine Peyer's patchesDC infectionDC subsetsOral antigenDC populationsOral tolerance