Trypanosoma brucei gambiense Group 1 Is Distinguished by a Unique Amino Acid Substitution in the HpHb Receptor Implicated in Human Serum Resistance
Symula RE, Beadell JS, Sistrom M, Agbebakun K, Balmer O, Gibson W, Aksoy S, Caccone A. Trypanosoma brucei gambiense Group 1 Is Distinguished by a Unique Amino Acid Substitution in the HpHb Receptor Implicated in Human Serum Resistance. PLOS Neglected Tropical Diseases 2012, 6: e1728. PMID: 22802982, PMCID: PMC3393672, DOI: 10.1371/journal.pntd.0001728.Peer-Reviewed Original ResearchConceptsTrypanosome lytic factorHuman serum resistanceGroup 2Group 1Serum resistanceHaptoglobin-hemoglobin receptorHuman serumHuman African trypanosomiasisInnate immunityTrypanosoma brucei rhodesienseUnique amino acid substitutionsAltered activityLytic factorCausative agentLytic activityHemoglobin receptorTLF-1African trypanosomiasisBrucei rhodesienseSerumReceptorsAmino acid substitutionsFurther evidenceHpHbRTBR