2017
Genomic analyses of African Trypanozoon strains to assess evolutionary relationships and identify markers for strain identification
Richardson JB, Lee KY, Mireji P, Enyaru J, Sistrom M, Aksoy S, Zhao H, Caccone A. Genomic analyses of African Trypanozoon strains to assess evolutionary relationships and identify markers for strain identification. PLOS Neglected Tropical Diseases 2017, 11: e0005949. PMID: 28961238, PMCID: PMC5636163, DOI: 10.1371/journal.pntd.0005949.Peer-Reviewed Original ResearchConceptsAfrican trypanosomesHigh genetic similarityMaximum likelihood phylogenyStrain identificationGenomic resourcesGenetic structureEvolutionary relationshipsGenetic clustersPhylogenetic analysisGenomic analysisSingle nucleotide polymorphismsTaxonomic classificationGenetic similarityLarge comparative analysisGenetic markersHigh similarityGeographic originEvansi strainsSNPsNucleotide polymorphismsT. brucei bruceiPhylogenyTrypanosomesTrypanosomaTrypanozoon
2016
Babesia microti from humans and ticks hold a genomic signature of strong population structure in the United States
Carpi G, Walter KS, Mamoun CB, Krause PJ, Kitchen A, Lepore TJ, Dwivedi A, Cornillot E, Caccone A, Diuk-Wasser MA. Babesia microti from humans and ticks hold a genomic signature of strong population structure in the United States. BMC Genomics 2016, 17: 888. PMID: 27821055, PMCID: PMC5100190, DOI: 10.1186/s12864-016-3225-x.Peer-Reviewed Original ResearchConceptsStrong population structurePopulation structureGenome-wide diversityDifferentiated genetic clustersRecent population expansionB. microti samplesTick-borne apicomplexan parasiteB. microtiNortheastern USAGene flowEvolutionary originApicomplexan parasitesApicoplast genomeGenetic clustersGenomic variationPopulation expansionGeographic rangeRange expansionGenomic signaturesCurrent diversityHuman-derived samplesInfectious phenotypeTick vectorCapture strategyDiversityComparative genomics of drug resistance in Trypanosoma brucei rhodesiense
Graf F, Ludin P, Arquint C, Schmidt R, Schaub N, Kunz Renggli C, Munday J, Krezdorn J, Baker N, Horn D, Balmer O, Caccone A, de Koning H, Mäser P. Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. Cellular And Molecular Life Sciences 2016, 73: 3387-3400. PMID: 26973180, PMCID: PMC4967103, DOI: 10.1007/s00018-016-2173-6.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAquaporinsComparative Genomic HybridizationDNA, ProtozoanDrug ResistanceGenome, ProtozoanHeterozygoteHumansMaleMelarsoprolNucleoside Transport ProteinsParasitic Sensitivity TestsPentamidinePhenotypePolymorphism, Single NucleotideProtozoan ProteinsRNA-Binding ProteinsSequence AlignmentTrypanocidal AgentsTrypanosoma brucei rhodesienseTrypanosomiasis, African