2018
Genetic Differentiation of Glossina pallidipes Tsetse Flies in Southern Kenya.
Okeyo WA, Saarman NP, Bateta R, Dion K, Mengual M, Mireji PO, Ouma C, Okoth S, Murilla G, Aksoy S, Caccone A. Genetic Differentiation of Glossina pallidipes Tsetse Flies in Southern Kenya. American Journal Of Tropical Medicine And Hygiene 2018, 99: 945-953. PMID: 30105964, PMCID: PMC6159567, DOI: 10.4269/ajtmh.18-0154.Peer-Reviewed Original ResearchConceptsGenetic differentiationPopulation dynamicsDispersal patternsTsetse fliesLow genetic diversityGreater genetic differentiationEvidence of admixtureWestern clusterEastern clusterRecent anthropogenic influencesAnimal African trypanosomiasisGenetic connectivityWestern relativesGenetic diversityMicrosatellite lociPopulation structureGenotypic dataWidespread signalDisease vectorsMajor vectorVector control effortsGreat Rift ValleyDemographic parametersFliesVector control programsUrban rat races: spatial population genomics of brown rats (Rattus norvegicus) compared across multiple cities
Combs M, Byers K, Ghersi B, Blum M, Caccone A, Costa F, Himsworth C, Richardson J, Munshi-South J. Urban rat races: spatial population genomics of brown rats (Rattus norvegicus) compared across multiple cities. Proceedings Of The Royal Society B 2018, 285: 20180245. PMID: 29875297, PMCID: PMC6015871, DOI: 10.1098/rspb.2018.0245.Peer-Reviewed Original ResearchMeSH KeywordsBrazilBritish ColumbiaCitiesCluster AnalysisGene FlowGenotypeNew OrleansNew York CityPolymorphism, Single NucleotideConceptsGene flowGenome-wide single nucleotide polymorphismsSpatial population genomicsGenome-wide diversityShortest distance classesGenerality of predictionsPopulation genomicsGenetic discontinuityLimited dispersalNeutral evolutionSingle nucleotide polymorphismsMultiple speciesPest managementSame speciesBrown ratsDifferent biomesDistance classesNucleotide polymorphismsAnimal movementSpeciesGenomicsMajor waterwaysCoancestryClustering analysisDispersal
2017
Temporal genetic differentiation in Glossina pallidipes tsetse fly populations in Kenya
Okeyo WA, Saarman NP, Mengual M, Dion K, Bateta R, Mireji PO, Okoth S, Ouma JO, Ouma C, Ochieng J, Murilla G, Aksoy S, Caccone A. Temporal genetic differentiation in Glossina pallidipes tsetse fly populations in Kenya. Parasites & Vectors 2017, 10: 471. PMID: 29017572, PMCID: PMC5635580, DOI: 10.1186/s13071-017-2415-y.Peer-Reviewed Original ResearchConceptsTemporal genetic differentiationGenetic diversityGenetic differentiationGenetic bottleneckGenetic variationNational ParkTemporal genetic variationExtensive control measuresAnimal African trypanosomiasisAllelic richnessPairwise FSTGenetic driftNe estimatesHabitat alterationPopulation geneticsTemporal differentiationMicrosatellite markersRuma National ParkClosest sampling sitesG. pallidipesMajor vectorTsetse fliesVector populationsDifferentiationDiversityIdentification of Genetically Important Individuals of the Rediscovered Floreana Galápagos Giant Tortoise (Chelonoidis elephantopus) Provides Founders for Species Restoration Program
Miller J, Quinzin M, Poulakakis N, Gibbs J, Beheregaray L, Garrick R, Russello M, Ciofi C, Edwards D, Hunter E, Tapia W, Rueda D, Carrión J, Valdivieso A, Caccone A. Identification of Genetically Important Individuals of the Rediscovered Floreana Galápagos Giant Tortoise (Chelonoidis elephantopus) Provides Founders for Species Restoration Program. Scientific Reports 2017, 7: 11471. PMID: 28904401, PMCID: PMC5597637, DOI: 10.1038/s41598-017-11516-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBreedingCluster AnalysisDNA, MitochondrialFounder EffectGenetic VariationGenotypeHumansMicrosatellite RepeatsTurtlesConceptsGiant tortoisesGalápagos giant tortoisesHuman-driven environmental changesCaptive breeding programsCaptive breeding centerSpecies restoration programsHigh ancestryFloreana IslandSpecies todayIsland ecosystemsBreeding programsGalápagos IslandsGenetic analysisBreeding CenterEnvironmental changesRestoration programsTortoisesSpeciesEcosystemsDistinctive morphologyAncestryUnprecedented rateIslandsTranslocationUnique opportunityTracking the return of Aedes aegypti to Brazil, the major vector of the dengue, chikungunya and Zika viruses
Kotsakiozi P, Gloria-Soria A, Caccone A, Evans B, Schama R, Martins AJ, Powell JR. Tracking the return of Aedes aegypti to Brazil, the major vector of the dengue, chikungunya and Zika viruses. PLOS Neglected Tropical Diseases 2017, 11: e0005653. PMID: 28742801, PMCID: PMC5526527, DOI: 10.1371/journal.pntd.0005653.Peer-Reviewed Original ResearchGenetic diversity and population structure of the tsetse fly Glossina fuscipes fuscipes (Diptera: Glossinidae) in Northern Uganda: Implications for vector control
Opiro R, Saarman NP, Echodu R, Opiyo EA, Dion K, Halyard A, Dunn AW, Aksoy S, Caccone A. Genetic diversity and population structure of the tsetse fly Glossina fuscipes fuscipes (Diptera: Glossinidae) in Northern Uganda: Implications for vector control. PLOS Neglected Tropical Diseases 2017, 11: e0005485. PMID: 28453513, PMCID: PMC5425221, DOI: 10.1371/journal.pntd.0005485.Peer-Reviewed Original ResearchConceptsAnimal African trypanosomiasisGenetic clustersEffective population size estimatesLake KyogaRecent population bottleneckMitochondrial DNA markersDistinct genetic clustersPolymorphic microsatellite lociNile drainagePopulation size estimatesGenetic structurePopulation bottlenecksMain haplogroupsGenetic diversityMicrosatellite lociGenetic assignmentDNA markersPopulation structureMtDNA analysisGenetic admixtureSampling sitesGenetic unitsMost populationsTrypanosoma parasitesHuman African trypanosomiasis
2012
The population structure of Glossina fuscipes fuscipes in the Lake Victoria basin in Uganda: implications for vector control
Hyseni C, Kato AB, Okedi LM, Masembe C, Ouma JO, Aksoy S, Caccone A. The population structure of Glossina fuscipes fuscipes in the Lake Victoria basin in Uganda: implications for vector control. Parasites & Vectors 2012, 5: 222. PMID: 23036153, PMCID: PMC3522534, DOI: 10.1186/1756-3305-5-222.Peer-Reviewed Original Research
2011
Genetic diversity and population structure of Glossina pallidipes in Uganda and western Kenya
Ouma JO, Beadell JS, Hyseni C, Okedi LM, Krafsur ES, Aksoy S, Caccone A. Genetic diversity and population structure of Glossina pallidipes in Uganda and western Kenya. Parasites & Vectors 2011, 4: 122. PMID: 21711519, PMCID: PMC3146932, DOI: 10.1186/1756-3305-4-122.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCluster AnalysisDNA, MitochondrialFemaleGenetic VariationGenotypeKenyaMaleMicrosatellite RepeatsTsetse FliesUgandaConceptsSex-biased dispersalGenetic diversityPopulation structureSource populationModern gene flowHigh genetic diversityMean genetic distanceAnalysis of mtDNAGene flowNuclear markersBayesian assignmentRelict populationsMtDNA haplotypesGenetic distanceMicrosatellite genotypesG. pallidipesGenetic variationPairwise relatednessMicrosatellite allelesMicrosatellite analysisDispersalSoutheastern UgandaFall populationPopulation comparisonsEffective control effortsPhylogeography and Taxonomy of Trypanosoma brucei
Balmer O, Beadell J, Gibson W, Caccone A. Phylogeography and Taxonomy of Trypanosoma brucei. PLOS Neglected Tropical Diseases 2011, 5: e961. PMID: 21347445, PMCID: PMC3035665, DOI: 10.1371/journal.pntd.0000961.Peer-Reviewed Original Research
2010
Phylogeography and Population Structure of Glossina fuscipes fuscipes in Uganda: Implications for Control of Tsetse
Beadell JS, Hyseni C, Abila PP, Azabo R, Enyaru JC, Ouma JO, Mohammed YO, Okedi LM, Aksoy S, Caccone A. Phylogeography and Population Structure of Glossina fuscipes fuscipes in Uganda: Implications for Control of Tsetse. PLOS Neglected Tropical Diseases 2010, 4: e636. PMID: 20300518, PMCID: PMC2838784, DOI: 10.1371/journal.pntd.0000636.Peer-Reviewed Original ResearchConceptsGene flowPopulation structureLarge-scale genetic structureDivergent mitochondrial lineagesCurrent gene flowScale genetic structureBayesian assignment testsLittle gene flowHistorical colonization eventsZone of contactSouthern lineagesMitochondrial lineagesAssignment testsGenetic structureArea-wide controlMainland populationsColonization eventsMicrosatellite dataPopulation geneticsPhylogeographic analysisRiverine speciesIsland populationsAppropriate geographical scaleGenetic analysisMicrosatellite structure
2003
Genetic structure of Mesoamerican populations of Big‐leaf mahogany (Swietenia macrophylla) inferred from microsatellite analysis
Novick R, Dick C, Lemes M, Navarro C, Caccone A, Bermingham E. Genetic structure of Mesoamerican populations of Big‐leaf mahogany (Swietenia macrophylla) inferred from microsatellite analysis. Molecular Ecology 2003, 12: 2885-2893. PMID: 14629370, DOI: 10.1046/j.1365-294x.2003.01951.x.Peer-Reviewed Original ResearchConceptsGenetic structurePhylogeographic structureStrong phylogeographic structureNeotropical tree speciesVariable microsatellite lociHigh-resolution markersBig-leaf mahoganyMahogany populationsGenetic differentiationCosta RicaBiogeographic historyNeotropical treeGenetic divergenceRegional biogeographyNative rangeNorthern populationsGenetic distanceGenetic diversityMicrosatellite lociAtlantic populationsPopulation structureAmerican treesMesoamerican populationsSwietenia macrophylla KingUnrooted dendrogram